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In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. Additionally we are shipping HNMT Antibodies (72) and HNMT Proteins (19) and many more products for this protein.
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HNMT is identified as a novel gene responsible for intellectual disability. The consequences of the identified missense mutations on the protein function are discussed.
HRH1 (show DHX8 ELISA Kits)-17 TT and HNMT-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP (show ABP1 ELISA Kits) 4107 GG genotype was associated with nonallergic asthma among white children.
results suggest that the heterozygous Thr/Ile genotype at the HNMT-Thr105Ile locus and the minor Ile105 allele protect against Parkinson's disease and schizophrenia in Han Chinese.
The polymorphisms of HNMT and HRH3 (show HRH3 ELISA Kits) were irrelevant with breast cancer in the present study.
The A939G HNMT polymorphism is associated with autoimmune MG, while no association with C314T SNP was found.
The results of this study indicated that Histamine N-methyltransferase Thr105Ile polymorphism is associated Parkinson's disease.
Lack of the association of HNMT Thr105Ile functional polymorphism with Alzheimer's disease is found.
our results suggest that, despite the possible role of histamine in the inflammatory processes related with the pathogenesis of MS, HNMT polymorphism is not related with the risk for MS in Caucasian Spanish people
This study do not support the HNMT Thr105Ile variant as a factor in disease development or a genetic link between the disorders.
identification of several novel HNMT polymorphisms, identification of the HNMT core promoter
Genomic structure of the rat and mouse histamine N-methyltransferase gene
decreasing expression over the time course of the skin pathological changes in MRL/lpr (show FAS ELISA Kits) mice
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
, Histamine N-methyltransferase