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In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. Additionally we are shipping HNMT Antibodies (73) and HNMT Kits (5) and many more products for this protein.
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Human HNMT Protein expressed in Escherichia coli (E. coli) - ABIN2005438
Yan, Galinsky, Bernstein, Liggett, Weinshilboum: Histamine N-methyltransferase pharmacogenetics: association of a common functional polymorphism with asthma. in Pharmacogenetics 2000
Show all 3 references for ABIN2005438
The T allele of rs3787429 exhibited protective effect against CHF under the dominant and additive models , while, for SNPs in HRH2 (show DHX15 Proteins), DAO (show ABP1 Proteins), and HNMT, no significant associations were observed in the present study
HNMT is identified as a novel gene responsible for intellectual disability. The consequences of the identified missense mutations on the protein function are discussed.
HRH1 (show DHX8 Proteins)-17 TT and HNMT-1639 TT genotypes were associated with the allergic asthma phenotype among African-American children and that the ABP (show ABP1 Proteins) 4107 GG genotype was associated with nonallergic asthma among white children.
results suggest that the heterozygous Thr/Ile genotype at the HNMT-Thr105Ile locus and the minor Ile105 allele protect against Parkinson's disease and schizophrenia in Han Chinese.
The polymorphisms of HNMT and HRH3 (show HRH3 Proteins) were irrelevant with breast cancer in the present study.
The A939G HNMT polymorphism is associated with autoimmune MG, while no association with C314T SNP was found.
The results of this study indicated that Histamine N-methyltransferase Thr105Ile polymorphism is associated Parkinson's disease.
Lack of the association of HNMT Thr105Ile functional polymorphism with Alzheimer's disease is found.
our results suggest that, despite the possible role of histamine in the inflammatory processes related with the pathogenesis of MS, HNMT polymorphism is not related with the risk for MS in Caucasian Spanish people
This study do not support the HNMT Thr105Ile variant as a factor in disease development or a genetic link between the disorders.
Genomic structure of the rat and mouse histamine N-methyltransferase gene
decreasing expression over the time course of the skin pathological changes in MRL/lpr (show FAS Proteins) mice
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
, Histamine N-methyltransferase