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HRC encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. Additionally we are shipping HRC Antibodies (25) and and many more products for this protein.
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The minimal KEKE motif of TRN (show TNPO1 ELISA Kits) involved in the interactions with CSQ2, HRC and RyR2 (show RYR2 ELISA Kits) within the Ca2 (show CA2 ELISA Kits)+ release units of cardiac sarcoplasmic reticulum has been defined.
While CASQ2 (show CASQ2 ELISA Kits) stabilizes RyR2 (show RYR2 ELISA Kits) rendering it refractory in the diastolic phase, HRC enhances RyR2 (show RYR2 ELISA Kits) activity facilitating RyR2 (show RYR2 ELISA Kits) recovery from refractoriness.
Ablation of HRC is associated with poorly regulated SR Ca(2 (show CA2 ELISA Kits)+)-cycling, and severe pathology under pressure-overload stress, suggesting an essential role of HRC in maintaining the integrity of cardiac function.
Results identify the HRC enhancer as the first MEF2-dependent, CArG-motif-independent transcriptional target in smooth muscle and represent the first analysis of the transcriptional regulation of a sarcoplasmic reticulum gene in vivo.
alterations in expression levels of HRC are associated with impaired cardiac SR Ca homeostasis and contractile function.
HRC may be an integral regulatory protein involved in cardiac muscle SR Ca uptake and Ca homeostasis
The exaggerated response of HRC knockout mice to the induction of cardiac hypertrophy is consistent with a regulatory role for HRC in calcium handling in vivo.
Histidine-rich Ca-binding protein may play a key role in the regulation of SR Ca cycling through its direct interactions with SERCA2 (show ATP2A2 ELISA Kits) and triadin (show TRDN ELISA Kits), mediating a fine cross talk between SR Ca uptake and release in the heart.
this study demonstrates a role of HRC in promoting hepatocellular carcinoma (HCC (show FAM126A ELISA Kits)) growth, besides its role in inducing HCC (show FAM126A ELISA Kits) metastasis, and highlights HRC as a promising intervention target for HCC (show FAM126A ELISA Kits).
Up-regulation of histidine-rich calcium binding protein promotes tumor metastasis in hepatocellular carcinoma and is mediated by SATB1 (show SATB1 ELISA Kits).
The S96A HRC mutation disrupts the Ca2 (show CA2 ELISA Kits)+ -microdomain around the RyR2 (show RYR2 ELISA Kits), as it alters the Ca2 (show CA2 ELISA Kits)+ -dependent association of RyR2 (show RYR2 ELISA Kits) and HRC.
findings suggest that aberrant sarcoplasmic reticulum Ca2 (show CA2 ELISA Kits)+ release and increased susceptibility to delayed afterdepolarizations underlie triggered arrhythmic activity in Ala96 HRC carriers
The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM.
This gene encodes a luminal sarcoplasmic reticulum protein identified by its ability to bind low-density lipoprotein with high affinity. The protein interacts with the cytoplasmic domain of triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle. The protein functions in the regulation of releasable calcium into the SR.
histidine rich calcium binding protein
, histidine-rich calcium-binding protein
, sarcoplasmic reticulum histidine-rich calcium-binding protein
, histidine rich calcium-binding protein