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Histidine Triad Nucleotide Binding Protein 1 Proteins (HINT1)

The protein encoded by HINT1 can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. Additionally we are shipping HINT1 Antibodies (55) and HINT1 Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HINT1 3094 P49773
HINT1 15254 P70349
HINT1 690660 P62959
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Top HINT1 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,253.17
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,253.17
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,253.17
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,253.17
Details
Yeast Caenorhabditis elegans His tag   1 mg Log in to see 56 to 66 Days
$2,267.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 μg Log in to see 6 to 11 Days
$142.86
Details

HINT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced HINT1 Proteins

  1. Human HINT1 Protein expressed in Escherichia coli (E. coli) - ABIN667109 : Bieganowski, Garrison, Hodawadekar, Faye, Barnes, Brenner: Adenosine monophosphoramidase activity of Hint and Hnt1 supports function of Kin28, Ccl1, and Tfb3. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667109

More Proteins for Histidine Triad Nucleotide Binding Protein 1 (HINT1) Interaction Partners

Human Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

  1. Absence of HINT1 mutations in a UK and Spanish cohort of patients with inherited neuropathies

  2. In hepatocellular carcinoma, HINT1 is a regulator of IkappaBalpha (show NFKBIA Proteins) through SCF (show KITLG Proteins)(beta-TrCP (show BTRC Proteins)) E3 ligase.

  3. HINT1 mutations seem to be one of the most frequent causes of inherited neuropathy and are probably the most frequent cause of HMN in Czech patients. We suggest all HMN/CMT2 patients be tested for the presence of the prevalent mutation, the p.R37P

  4. The teneurin-1 intracellular domain binds HINT1, thus switching on MITF-dependent transcription of GPNMB.

  5. Data suggest that histidine triad nucleotide binding protein 1 (HINT1) should be added to the list of genes to check for in distal hereditary motor neuropathies (dHMNs).

  6. Study gives suggestive evidence that HINT1 rs3852209 may be related to smoking status in Chinese men.

  7. BTF3 (show BTF3 Proteins), HINT1, NDRG1 (show NDRG1 Proteins) and ODC1 (show ODC1 Proteins) protein over-expression in human prostate cancer tissue

  8. Histidine triad nucleotide-binding protein 1, bifunctional aminoacyl-tRNA synthetase (show EPRS Proteins), and clusterin (show CLU Proteins) precursor protein may serve as potential biomarkers distinguishing type 2 diabetes mellitus patients from healthy controls.

  9. loss of functional HINT1 protein results in a distinct phenotype of autosomal recessive axonal neuropathy with neuromyotonia.

  10. The results reveal the structural basis for the remarkable adenylate surveillance activity of Hint1, to potentially control Ap(4 (show REPIN1 Proteins))A levels in the cell.

Mouse (Murine) Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

  1. It was observed that HINT1 protein binds to GPCRs and NMDAR NR1 (show GRIN1 Proteins) subunits in a calcium-independent manner, whereas sigma1R (show SIGMAR1 Proteins) binding to these proteins increases in the presence of calcium.

  2. Results suggest that Hint1 deficiency leads to an increased protein level of PKC gamma (show PRKCG Proteins) in the brain and a compromised activation response of PKC gamma (show PRKCG Proteins) upon stimulation

  3. HINT1 is involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions.

  4. These results further support a role for HINT1 in nicotine-mediated behaviors and suggest that alterations in the gene may have differential effects on phenotype in males and females.

  5. Activated mu-opioid receptors stimulate the production of nitric oxide (NO), and the redox zinc switch RGSZ2 (show RGS17 Proteins) converts this signal into free zinc ions that are required to recruit the redox sensor PKCgamma (show PRKCG Proteins) to HINT1 proteins.

  6. lipidomic phenotype of the Hint1(-/-) mouse

  7. these mice do not provide a disease model or a means for investigating the basis of HINT1-associated neuropathy and neuromyotonia

  8. Cannabinoids that act through CNR1 (show CNR1 Proteins) maintain the negative control of HINT1 on NMDAR (show GRIN1 Proteins) function and their protection against glutamate (show GRIN1 Proteins) excitotoxic insult persists.

  9. our data support a role for the HINT1 gene in mediating behaviors associated with nicotine reward and physical nicotine withdrawal, and provide insight into the role of HINT1 in nicotine dependence-like behaviors.

  10. Thus the study demonstrates a novel function of HINT1 that involves the regulation of store-operated channel-mediated Ca(2 (show CA2 Proteins)+) entry pathway

Rabbit Histidine Triad Nucleotide Binding Protein 1 (HINT1) interaction partners

  1. structure of the rabbit HINT1-adenosine complex is reported at 1.10 A resolution, which is one of the highest resolutions obtained for a HINT1 structure

HINT1 Protein Profile

Protein Summary

The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene.

Gene names and symbols associated with HINT1

  • histidine triad nucleotide binding protein 1 (HINT1)
  • histidine triad nucleotide binding protein 1 (hint1)
  • histidine triad nucleotide binding protein 1 (Hint1)
  • Protein HINT-1 (hint-1)
  • AA673479 protein
  • CHPKCI protein
  • Hint protein
  • HINTZ protein
  • Ipk1 protein
  • NMAN protein
  • Pkci protein
  • PKCI-1 protein
  • PKCIZ protein
  • Prkci protein
  • PRKCNH1 protein
  • zgc:103764 protein

Protein level used designations for HINT1

histidine triad nucleotide binding protein 1 , PKCI-Z-related protein , adenosine 5'-monophosphoramidase , histidine triad nucleotide-binding protein 1 , protein kinase C inhibitor 1 , protein kinase C-interacting protein 1 , PKC inhibitor/ interacting protein , 17 kDa inhibitor of protein kinase C , PKCI-1 , protein kinase C, iota , histidine triad missing Z , protein kinase C inhibitor , P13.7

GENE ID SPECIES
462040 Pan troglodytes
548919 Xenopus (Silurana) tropicalis
751976 Taeniopygia guttata
3094 Homo sapiens
15254 Mus musculus
690660 Rattus norvegicus
449551 Danio rerio
447082 Xenopus laevis
395424 Gallus gallus
327693 Bos taurus
100009302 Oryctolagus cuniculus
474667 Canis lupus familiaris
100171549 Pongo abelii
184760 Caenorhabditis elegans
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