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Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002. Additionally we are shipping Histidine Triad Nucleotide Binding Protein 2 Proteins (8) and Histidine Triad Nucleotide Binding Protein 2 Kits (4) and many more products for this protein.
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findings reveal a novel signalling pathway involved in development of the semicircular canal system, and suggest a previously unrecognized role for NCS-1 (show NCS1 Antibodies) in mitochondrial function via its association with several mitochondrial proteins.
HINT2 downregulation depended on hypoxia inducible factor (HIF)-2alpha (show EPAS1 Antibodies)-mediated transcriptional activation of zinc finger E-box-binding homeobox 1 (ZEB1 (show ZEB1 Antibodies)). These results suggest that HINT2 downregulation promotes HIF-2alpha (show EPAS1 Antibodies) expression, which induces EMT (show ITK Antibodies) and enhances CRC (show CALR Antibodies) cell migration and invasion.
Low HINT2 expression is associated with low response to therapy in endometrial cancer.
X-ray crystal structure of human HINT2 with and without bound AMP (show APRT Antibodies).
Hint2 is required for an optimal steroidogenic response, possibly because of a particular signalling function exerted within the mitochondria.
The absence of Hint2 deregulates the posttranslational modification of several mitochondrial proteins, which impedes the adaptation to episodes of nutritional stress.
the effect of the mitochondrial protein (show COX6B2 Antibodies) Hint2 on intracellular Ca(2 (show CA2 Antibodies)+) dynamics
Hint2/HINT2 positively regulates mitochondrial lipid metabolism and respiration and glucose homeostasis.
Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002
histidine triad nucleotide binding protein 2
, histidine triad nucleotide-binding protein
, histidine triad nucleotide-binding protein 2, mitochondrial
, PKCI-1-related HIT protein
, protein kinase C inhibitor-2