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Histidine-Rich Glycoprotein Proteins (HRG)

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. Additionally we are shipping Histidine-Rich Glycoprotein Antibodies (27) and Histidine-Rich Glycoprotein Kits (14) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HRG 94175 Q9ESB3
HRG 3273 P04196
HRG 171016 Q99PS8
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Top Histidine-Rich Glycoprotein Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg Log in to see 11 to 13 Days
$809.60
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$844.80
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,094.67
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,439.33
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HRG Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
Rat (Rattus) ,
,

More Proteins for Histidine-Rich Glycoprotein (HRG) Interaction Partners

Mouse (Murine) Histidine-Rich Glycoprotein (HRG) interaction partners

  1. HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

  2. Mice deficient in HRG have normal hemostasis, but demonstrate accelerated thrombosis via the contact system.

  3. mononuclear phagocytes have specific binding sites for HRG and that these cells are essential for uptake of HRG from blood and distribution of HRG in tissues. Thus, inflammatory cells mediate the effect of HRG on tumor growth and metastatic spread.

  4. Results show that HRG is a novel transcriptional target gene of FXR (show NR1H4 Proteins) in human hepatoma cells, human upcyteVR primary hepatocytes and 3D human liver microtissues in vitro and in mouse liver in vivo.

  5. HRG-deficiency promotes tumor progression via enhanced platelet activity. HRG is a potent tumor suppressor, with capacity to attenuate the angiogenic switch, tumor growth, EMT (show ITK Proteins) and subsequent metastatic spread, by regulating platelet activity.

  6. CD36 (show CD36 Proteins)-mediated anti-angiogenic activity has context-dependent role in the tumor microenvironment in the presence of TSP-1 (show GZMA Proteins) while HRG modulates this activity.

  7. HRG loss influences macrophage gene regulation, leading to excessive stimulation of tumor angiogenesis, suppression of tumor immune response, and increased tumor growth and metastatic spread

  8. the identification and characterization of a novel peptide, VTIP-peptide (VTIP-P), which binds and enhances the activation of CREM (show CREM Proteins)/CREB (show CREB1 Proteins)

  9. role for HRG as a regulator of inflammation and in the defense at the local site of bacterial infection

  10. HRG acts as a soluble adaptor molecule that binds to cells at sites of tissue injury, tumor growth, and angiogenesis

Human Histidine-Rich Glycoprotein (HRG) interaction partners

  1. HRG (show NRG1 Proteins) attenuates DNA- and RNA-mediated FXII (show F12 Proteins) activation, and FXI (show F11 Proteins) activation by FXIIa or by thrombin (show F2 Proteins), suggesting that HRG (show NRG1 Proteins) down regulates the capacity of DNA and RNA to activate the intrinsic coagulation pathway.

  2. HRG (show NRG1 Proteins) binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.

  3. HRG could inhibit hepatocellular carcinoma cell proliferation via the FGF-Erk1/2 signaling pathway by reducing Erk1/2 phosphorylation.

  4. Plasma free fatty acid levels influence Zn(2+) -dependent histidine-rich glycoprotein-heparin interactions via an allosteric switch on serum albumin (show ALB Proteins).

  5. mononuclear phagocytes have specific binding sites for HRG (show NRG1 Proteins) and that these cells are essential for uptake of HRG (show NRG1 Proteins) from blood and distribution of HRG (show NRG1 Proteins) in tissues. Thus, inflammatory cells mediate the effect of HRG (show NRG1 Proteins) on tumor growth and metastatic spread.

  6. Results show that HRG (show NRG1 Proteins) is a novel transcriptional target gene of FXR (show NR1H4 Proteins) in human hepatoma cells, human upcyteVR primary hepatocytes and 3D human liver microtissues in vitro and in mouse liver in vivo.

  7. genetic association study in Swedish population: Data suggest SNP in HRG (show NRG1 Proteins) (rs2228243, A1042G) is associated with recurrent miscarriage in population studied; women heterozygous for HRG (show NRG1 Proteins) A1042G SNP are protected from recurrent miscarriage. [PILOT STUDY]

  8. histidine-rich glycoprotein tissue RNA and serum protein might have a role in breast cancer

  9. HRG (show NRG1 Proteins) does not exhibit the broad interactive properties that have been reported previously, suggesting that copurification of HRG (show NRG1 Proteins)-binding partners or other impurities are responsible for some of the reported functional properties.

  10. Association between the histidine-rich glycoprotein (HRG) C633T single nucleotide polymorphism (SNP) and recurrent miscarriage was investigated. An association between homozygous carriers and recurrent miscarriage was detected.

Cow (Bovine) Histidine-Rich Glycoprotein (HRG) interaction partners

  1. the anti-angiogenic His/Pro-rich fragment of histidine-rich glycoprotein binds to endothelial cell heparan sulfate in a Zn2+-dependent manner

Rabbit Histidine-Rich Glycoprotein (HRG) interaction partners

  1. The structure confirms that the N2 domain, which along with the N1 domain, forms an important molecular interaction site on HRG, possesses a cystatin (show CST3 Proteins)-like fold composed of a 5-stranded antiparallel beta-sheet wrapped around a 5-turn alpha-helix.

Histidine-Rich Glycoprotein (HRG) Protein Profile

Protein Summary

This histidine-rich glycoprotein contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.

Gene names and symbols associated with HRG

  • histidine-rich glycoprotein (HRG)
  • histidine-rich glycoprotein (LOAG_12427)
  • histidine-rich glycoprotein (Hrg)
  • AI265597 protein
  • AW413091 protein
  • D16jh2 protein
  • D18020 protein
  • HPRG protein
  • HRG1 protein
  • HRGP protein
  • THPH11 protein

Protein level used designations for HRG

histidine-rich glycoprotein , histidine-proline-rich glycoprotein , histidine-rich glycoprotein 1

GENE ID SPECIES
460914 Pan troglodytes
699100 Macaca mulatta
9949886 Loa loa
100431732 Pongo abelii
100597044 Nomascus leucogenys
94175 Mus musculus
3273 Homo sapiens
171016 Rattus norvegicus
280820 Bos taurus
100009395 Oryctolagus cuniculus
100152095 Sus scrofa
770588 Gallus gallus
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