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Histocompatibility (Minor) 13 Proteins (HM13)

The protein encoded by HM13, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. Additionally we are shipping Histocompatibility (Minor) 13 Antibodies (38) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HM13 81502 Q8TCT9
HM13 14950 Q9D8V0
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Top Histocompatibility (Minor) 13 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 0.025 mg Log in to see 2 to 3 Days
$433.13
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

HM13 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Histocompatibility (Minor) 13 (HM13) Interaction Partners

Human Histocompatibility (Minor) 13 (HM13) interaction partners

  1. structure of human SPP [SPP]

  2. identified human signal peptide peptidase as a polytopic membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases [SPP]

  3. identification and molecular cloning; expression analysis of the hIMP1 gene (located on chromosome 20) was performed in human cell tissues and transfected cell cultures [IMP1 (show IMPA1 Proteins)]

  4. widespread expression of SPP in many tissues

  5. signal peptide peptidase forms a homodimer that is labeled by an active site-directed gamma-secretase inhibitor

  6. IMP1 (show IMPA1 Proteins) is a bi-aspartic polytopic protease capable of cleaving transmembrane proteins such as presenilin 2 (show PSEN2 Proteins).

  7. The peptide structure corresponding to the C-terminal residues from H13 ribosomal protein was determined using magnetic resonance spectroscopy.

  8. SPP, SPPL2a (show SPPL2A Proteins), -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  9. data implicate SPP in the US2 pathway and indicate the possibility of a previously unknown function for this intramembrane-cleaving aspartic protease in dislocation from the endoplasmic reticulum

  10. Upon isolation of membranes and solubilization with detergent, the biochemical characteristics of SPP are remarkably similar to gamma-secretase.

Mouse (Murine) Histocompatibility (Minor) 13 (HM13) interaction partners

  1. silencing of SPP and its family member SPPL2a led to a general reduction of surface peptide-MHC-I complexes, underlining the involvement of these enzymes in Ag processing and presentation.

  2. structural analysis of H13 peptides lacking MHC binding anchor motifs determines self-nonself discrimination

  3. widespread expression of SPP in many tissues; a distinct pattern of expression in the mature murine brain and during development indicates that SPP plays an important role in the establishment and maintenance of the nervous system

  4. A single minor histocompatibility antigen mismatch at the polymorphic H13 allele plays a role in chronic allograft rejection of solid organs such as obliterative airway disease development following murine tracheal transplantation.

  5. new splice variant,signal peptide peptidase (SPP)beta, with an additional in-frame exon inserted between exons 11 and 12 of SPPalpha

  6. Results show that two genetic systems show that alleles lacking methylation generate truncated H13 transcripts that undergo internal polyadenylation.

Histocompatibility (Minor) 13 (HM13) Protein Profile

Protein Summary

The protein encoded by this gene, which localizes to the endoplasmic reticulum, catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein. This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the immune system, and to process hepatitis C virus core protein. The encoded protein is an integral membrane protein with sequence motifs characteristic of the presenilin-type aspartic proteases. Multiple transcript variants encoding several different isoforms have been found for this gene.

Gene names and symbols associated with HM13

  • histocompatibility (minor) 13 (hm13)
  • histocompatibility (minor) 13 (HM13)
  • histocompatibility 13 (H13)
  • 1200006O09Rik protein
  • 4930443L17Rik protein
  • 5031424B04Rik protein
  • AV020344 protein
  • cb228 protein
  • dJ324O17.1 protein
  • H-13 protein
  • h13 protein
  • Hm13 protein
  • IMP1 protein
  • IMPAS protein
  • IMPAS-1 protein
  • MGC68919 protein
  • MSTP086 protein
  • PSENL3 protein
  • PSL3 protein
  • Spp protein
  • SPPL1 protein
  • wu:fc11a06 protein
  • zgc:56660 protein
  • zgc:86862 protein

Protein level used designations for HM13

histocompatibility 13 , signal peptide peptidase , intramembrane aspartyl protease , histocompatibility (minor) 13 , minor histocompatibility antigen 13 , minor histocompatibility antigen H13 , minor histocompatibility antigen H13-like , IMP-1 , hIMP1 , intramembrane protease 1 , presenilin-like protein 3 , signal peptide peptidase beta , signal peptide peptidase like 1 , presenilin-like aspartyl protease

GENE ID SPECIES
259190 Danio rerio
380568 Xenopus laevis
469911 Pan troglodytes
512534 Bos taurus
608355 Canis lupus familiaris
713216 Macaca mulatta
100010776 Monodelphis domestica
100053502 Equus caballus
100124822 Xenopus (Silurana) tropicalis
100348554 Oryctolagus cuniculus
100386877 Callithrix jacchus
100447672 Pongo abelii
100582871 Nomascus leucogenys
81502 Homo sapiens
14950 Mus musculus
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