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HAT encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. Additionally we are shipping HAT Kits (7) and and many more products for this protein.
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Oga (show MGEA5 Antibodies)(+/-) mice resist high-fat diet-induced obesity with ameliorated hepatic steatosis and improved glucose metabolism
plays a critical role in placental vasculogenesis by modulating HIF-1alpha (show HIF1A Antibodies) stabilization
E2F1 (show E2F1 Antibodies) negatively regulates both Ogt (show OGT Antibodies) and Mgea5 (show MGEA5 Antibodies) expression in an Rb1 (show RB1 Antibodies) protein-dependent manner.
Conditional disruption of the O-GlcNAcase (show MGEA5 Antibodies) in mice leads to metabolic deregulation and semi-penetrant perinatal lethality.
This work identifies the first target of miR (show MLXIP Antibodies)-539 in the heart and the first miRNA that regulates OGA (show MGEA5 Antibodies).
The O-GlcNAcase (show MGEA5 Antibodies) active site resembles those of glycosidases which carry out the hydrolysis of GlcNAc linkages in a substrate-assisted acid-base manner.
HAT (show MGEA5 Antibodies) expression may potentially be useful as a marker for clinical grading and assessment of patient prognosis in squamous cell carcinomas
H9N2 viruses with R-S-S-R or R-S-R-R cleavage sites in hemagglutinin (show HA Antibodies) are activated by matriptase (show ST14 Antibodies) in addition to HAT (show MGEA5 Antibodies) and TMPRSS2 (show TMPRSS2 Antibodies) and, therefore, can be activated in a wide range of tissues what may affect virus spread, tissue tropism and pathogenicity.
TMPRSS2 (show TMPRSS2 Antibodies) and HAT (show MGEA5 Antibodies) are expressed by important influenza and SARS (show SARS Antibodies)-coronavirus target cells and could thus support viral spread in the human host.
results suggest that HAI-1 (show SPINT1 Antibodies) functions as a physiological regulator of HAT (show MGEA5 Antibodies) by inhibiting its protease activity and proteolytic activation in airway epithelium.(HAT (show MGEA5 Antibodies))
HAT (show MGEA5 Antibodies) cleaves proMSP at the physiological activation site
Human HAT (show MGEA5 Antibodies) cleaved severe acute respiratory syndrome coronavirus spike protein at R667, as determined by mutagenesis and mass spectrometry.
HAT (show MGEA5 Antibodies) regulates cellular functions of human bronchial epithelial cells via activation of protease-activated receptor-2 (show F2RL1 Antibodies).
HAT (show MGEA5 Antibodies) might promote PAR-2 (show F2RL1 Antibodies)-mediated IL-8 (show IL8 Antibodies) production to accumulate inflammatory cells in the epidermal layer of psoriasis.
results indicate that HAT (show MGEA5 Antibodies) stimulates fibroblast proliferation in bronchial airways through a PAR-2 (show F2RL1 Antibodies)-dependent MEK (show MAP2K1 Antibodies)-MAPK (show MAPK1 Antibodies) mediated pathway and that HAT (show MGEA5 Antibodies) is linked to airway processes involving fibroblasts
HAT (show MGEA5 Antibodies) induces amphiregulin (show AREG Antibodies) production through the PAR-2 (show F2RL1 Antibodies) mediated ERK (show EPHB2 Antibodies) pathway, and then causes amphiregulin (show AREG Antibodies) release by a TACE (show ADAM17 Antibodies)-dependent mechanism
This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions.
, bifunctional protein NCOAT
, meningioma-expressed antigen 5
, nuclear cytoplasmic O-GlcNAcase and acetyltransferase
, airway trypsin like protease
, airway trypsin-like protease
, transmembrane protease serine 11D