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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Additionally we are shipping Histone Cluster 3, H3 Proteins (5) and Histone Cluster 3, H3 Kits (2) and many more products for this protein.
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Data suggest that, during monocyte-into-macrophage differentiation, extensive trimethylation of histone H3 lysine 4 as well as histone H3 lysine 27 promotes occupancy of histone H3 at promoters of transcription factors such as HOXA (homeodomain proteins) and FOXO (forkhead transcription factors).
Data suggest post-translational modifications of histones, trimethylation of lysine 36 in H3 (H3K36me3) and acetylation of lysine 16 in H4 (H4K16ac), have roles in DNA damage repair; H3K36me3 stimulates H4K16ac upon DNA double-strand break; SETD2 (show SETD2 Antibodies), LEDGF (show PSIP1 Antibodies), and KAT5 (show KAT5 Antibodies) are required for these epigenetic changes. (SETD2 (show SETD2 Antibodies) = SET domain containing 2 (show SETD2 Antibodies); LEDGF (show PSIP1 Antibodies) = lens epithelium-derived growth factor (show PSIP1 Antibodies); KAT5 (show KAT5 Antibodies) = lysine acetyltransferase 5 (show KAT5 Antibodies))
Data show that tet oncogene family member 2 (TET2 (show TET2 Antibodies)) cysteine-rich (CR) domain mutations disrupt the recognition of histone H3 lysine 36 (H3K36) methylation, its cellular localization, and enzyme activity.
Screening for H3.3 G34 (show GAST Antibodies) mutation should therefore be recommended as a routine diagnostic marker for supratentorial central nervous system tumors
Regulators of the histone H3-trimethyl lysine-4 (H3K4me3) mark are significantly associated with the genetic risk architecture of common neurodevelopmental disease.
EP400 deposits H3.3 into chromatin alongside H2AZ and contributes to gene regulation after Pol II pre-initiation complex assembly.
Concurrent acetylation and methylation at H3K27 occurs in hepatocellular carcinoma cells in association with p53 (show TP53 Antibodies) abnormalities.
TIP60 (show KAT5 Antibodies) interacted with H3K4me3 in response to TNF-alpha (show TNF Antibodies) signaling.
Our data highlights the complex interplay between Nrf2 (show GABPA Antibodies) and H3S10 phosphorylation in arsenite-activated HO-1 (show HMOX1 Antibodies) transcription.
This study showed that Pediatric brainstem oligodendroglial tumors can include histone H3.3 (show H3F3A Antibodies)-mutated tumors and have a tendency to disseminate throughout the neuroaxis at the time of relapse.
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails\\\\; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.
H3 histone family, member T
, histone 3, H3
, histone H3.1t
, histone cluster 3, H3