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HDAC11 encodes a class IV histone deacetylase. Additionally we are shipping Histone Deacetylase 11 Antibodies (116) and many more products for this protein.
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Overexpressing any of HDAC 3 (show HDAC3 Proteins), 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X (show FMR1 Proteins) tremor ataxia (show USP14 Proteins) syndrome.
High HDAC11 expression is associated with neoplasms.
Data indicate a pronounced deregulation of HDAC (show HDAC3 Proteins) genes HDAC9 (show HDAC9 Proteins) and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (show IGF2BP3 Proteins) (PV) and primary myelofibrosis (PMF (show PRB1 Proteins)).
These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L (show TNFSF4 Proteins) expression.
HDAC11 associates with replication origins inhibits Cdt1 (show CDT1 Proteins)-induced re-replication and suppresses MCM loading.
We found a reduction of HDAC 11 mRNA and increased HDAC 2 (show HDAC2 Proteins) levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls.
Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer.
the absence of tumour-specific somatic events in WNT7A (show WNT7A Proteins) and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours
HDAC11 negatively regulated expression of the gene encoding interleukin 10 (show IL10 Proteins) in antigen-presenting cells.
Cdt1 (show CDT1 Proteins) undergoes acetylation and is reversibly deacetylated by HDAC11
HDAC11 appears to function as a negative regulator of myeloid-derived suppressor cells expansion/function in vivo.
HDAC6 (show HDAC6 Proteins), primarily a cytoplasmic protein (show BLZF1 Proteins), associates with HDAC11 and modulates the expression of IL-10 (show IL10 Proteins) as a transcriptional activator.
The HDAC11 transcript is a PDGF (show PDGFA Proteins) target; the HDAC11 mRNA abundance correlates inversely with proliferative status.
Male gender and male hormones accelerate kidney ischemia reperfusion-induced decreases in expression and binding of HDAC11, resulting in an increase in PAI-1 (show SERPINE1 Proteins) expression.
Role for HDAC11 in central nervous system histone deacetylation and the development of oligodendrocytes and neurons during postnatal development.
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
, histone deacetylase X
, histone deacetylase 11