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HDAC11 encodes a class IV histone deacetylase. Additionally we are shipping Histone Deacetylase 11 Antibodies (119) and Histone Deacetylase 11 Proteins (6) and many more products for this protein.
Overexpressing any of HDAC 3 (show HDAC3 ELISA Kits), 6, or 11 suppresses CGG repeat-induced neurodegeneration in a Drosophila model of fragile X (show FMR1 ELISA Kits) tremor ataxia (show USP14 ELISA Kits) syndrome.
High HDAC11 expression is associated with neoplasms.
Data indicate a pronounced deregulation of HDAC (show HDAC3 ELISA Kits) genes HDAC9 (show HDAC9 ELISA Kits) and HDAC11 in patients with Philadelphia-negative chronic myeloproliferative neoplasms: essential thrombocythemia (ET), polycythemia vera (show IGF2BP3 ELISA Kits) (PV) and primary myelofibrosis (PMF (show PRB1 ELISA Kits)).
These results demonstrate for the first time that HDAC11 plays an essential role in regulating OX40L (show TNFSF4 ELISA Kits) expression.
HDAC11 associates with replication origins inhibits Cdt1 (show CDT1 ELISA Kits)-induced re-replication and suppresses MCM loading.
We found a reduction of HDAC 11 mRNA and increased HDAC 2 (show HDAC2 ELISA Kits) levels in amyotrophic lateral sclerosis brain and spinal cord compared with controls.
Fluorescence in situ hybridization analysis localized HDAC11 gene to chromosome 3p25, a region characterized by frequent gains and losses of chromosomal material in a number of various types of cancer.
the absence of tumour-specific somatic events in WNT7A (show WNT7A ELISA Kits) and HDAC11 suggests that these genes are unlikely to have a classical tumour suppressor gene role in sporadic malignant pancreatic endocrine tumours
HDAC11 negatively regulated expression of the gene encoding interleukin 10 (show IL10 ELISA Kits) in antigen-presenting cells.
Cdt1 (show CDT1 ELISA Kits) undergoes acetylation and is reversibly deacetylated by HDAC11
HDAC11 appears to function as a negative regulator of myeloid-derived suppressor cells expansion/function in vivo.
HDAC6 (show HDAC6 ELISA Kits), primarily a cytoplasmic protein, associates with HDAC11 and modulates the expression of IL-10 (show IL10 ELISA Kits) as a transcriptional activator.
The HDAC11 transcript is a PDGF (show PDGFA ELISA Kits) target; the HDAC11 mRNA abundance correlates inversely with proliferative status.
Male gender and male hormones accelerate kidney ischemia reperfusion-induced decreases in expression and binding of HDAC11, resulting in an increase in PAI-1 (show SERPINE1 ELISA Kits) expression.
Role for HDAC11 in central nervous system histone deacetylation and the development of oligodendrocytes and neurons during postnatal development.
This gene encodes a class IV histone deacetylase. The encoded protein is localized to the nucleus and may be involved in regulating the expression of interleukin 10. Alternative splicing results in multiple transcript variants.
, histone deacetylase X
, histone deacetylase 11