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Histone Deacetylase 5 Proteins (HDAC5)

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Additionally we are shipping Histone Deacetylase 5 Antibodies (169) and Histone Deacetylase 5 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HDAC5 10014 Q9UQL6
HDAC5 15184  
Rat HDAC5 HDAC5 84580  
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Top Histone Deacetylase 5 Proteins at

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Baculovirus Human His tag HDAC5 catalytic domain activity assay. Recombinant HDAC5 catalytic domain activity measured using a fluorescent HDAC assay. HDAC5 catalytic domain protein gel. HDAC5 catalytic domain run on an SDS-PAGE gel and stained with Coomassie blue. 10 μg Log in to see 1 to 2 Days
HOST_Sf-9 cells Human His tag   50 μg Log in to see 3 to 4 Days
HOST_Baculovirus infected Insect Cells Mouse GST tag   5 μg Log in to see 10 to 12 Days

HDAC5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
Mouse (Murine) ,

More Proteins for Histone Deacetylase 5 (HDAC5) Interaction Partners

Human Histone Deacetylase 5 (HDAC5) interaction partners

  1. HDAC5 promotes cellular proliferation through the upregulation of cMet, and may provide a novel therapeutic target for the treatment of patients with Wilms' tumor.

  2. HDAC5 and HDAC6 (show HDAC6 Proteins) were highly expressed in melanoma cells but exhibited low expression levels in normal skin cells.

  3. Formononetin-combined therapy may enhance the therapeutic efficacy of doxorubicin in glioma cells by preventing EMT (show ITK Proteins) through inhibition of HDAC5.

  4. These results suggest a strong regulatory function of HDAC5 in the pro-inflammatory response of macrophages.

  5. In erythroid cells, pull down experiments identified the presence of a novel complex formed by HDAC5, GATA1, EKLF and pERK which was instead undetectable in cells of the megakaryocytic lineage.

  6. Data reveal a novel role of HDAC5 in modulating the KLF2 (show KLF2 Proteins) transcriptional activation and eNOS (show NOS3 Proteins) expression.

  7. Studied phosphorylation sites within functional HDAC5 domains, including the deacetylation domain (DAC (show AADAC Proteins), Ser755), nuclear export signal (NES (show NES Proteins), Ser1108), and an acidic domain (AD, Ser611).

  8. mRNA and protein levels of HDAC5 were up-regulated in human hepatocellular carcinoma.

  9. HDAC5 promoted the Six1 (show SIX1 Proteins) expression.

  10. In C2C12 myoblasts, recombinant human HDAC5 phosphorylation by PKD (show PRKD1 Proteins) regulated the expression of diverse metabolic genes and glucose metabolism.

Mouse (Murine) Histone Deacetylase 5 (HDAC5) interaction partners

  1. HDAC6 (show HDAC6 Proteins) is an effector of the immune cytotoxic response that acts by affecting the dynamics, transport and secretion of lytic granules by cytotoxic T lymphocytes.

  2. This study demonstrated that mice with learned helplessness protocol-induced behavioral despair exhibited higher levels of HDAC5 and HDAC5 binding to the promoter region of BDNF (show BDNF Proteins) exon IV resulting in the decreased expression of BDNF (show BDNF Proteins).

  3. It protects neurons from toxicity of prion (show PRNP Proteins) peptide, and that this protection occurs at through the regulation of the PI3k-Akt (show AKT1 Proteins)-mTOR (show FRAP1 Proteins) axis.

  4. mass spectrometry-based quantitative comparison of acetylated peptides from wild-type vs HDAC6 (show HDAC6 Proteins) knockout mice allowed to identify six new deacetylation sites possibly mediated by HDAC6 (show HDAC6 Proteins).

  5. We therefore tested that reducing HDAC6 (show HDAC6 Proteins) levels by genetic manipulation would attenuate early cognitive and behavioral deficits in R6/1 mice

  6. HDAC6 plays an important role in the function of CMA pathway under the HI stress induced by SCI and it may be a potential therapeutic target in acute SCI model.

  7. inhibition of HDAC5 differentially regulates ghrelin (show GHRL Proteins) and NUCB2/ nesfatin-1 (show NUCB2 Proteins) expression by enhancing the acetylation and phosphorylation of Raptor (show RPTOR Proteins), which subsequently suppress mTORC1 signaling

  8. Results suggest a role for Hdac5 and Sirt2 (show SIRT2 Proteins) in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression

  9. loss of HDAC5 weakens Treg suppressive function and iTreg formation, as well as IFN-gamma (show IFNG Proteins) production in CD8 (show CD8A Proteins)+ T cells. Mice lacking HDAC5 do not develop spontaneous illness and do not have enhanced anti-tumor immunity.

  10. functional loss or suppression of the tumor suppressor HDAC6 (show HDAC6 Proteins) is caused by induction of miR (show MLXIP Proteins)-221 through coordinated JNK/c-Jun- and NF-kappaB (show NFKB1 Proteins)-signaling pathways during liver tumorigenesis

Cow (Bovine) Histone Deacetylase 5 (HDAC5) interaction partners

  1. Protein kinase D-HDAC5 pathway plays an important role in VEGF regulation of gene transcription and angiogenesis

Arabidopsis thaliana Histone Deacetylase 5 (HDAC5) interaction partners

  1. Regulation of flowering time by the histone deacetylase HDA5

Histone Deacetylase 5 (HDAC5) Protein Profile

Protein Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Histone Deacetylase 5 Proteins (HDAC5)

  • histone deacetylase 5 (HDAC5)
  • histone deacetylase 5 (Hdac5)
  • histone deacetylase 5 (HDA05)
  • histone deacetylase 6 (Hdac6)
  • AI426555 protein
  • ATHDA5 protein
  • DKFZp459O115 protein
  • HD5 protein
  • Hd6 protein
  • HDA5 protein
  • Hdac4 protein
  • Hdac5 protein
  • histone deacetylase 5 protein
  • MAF19.7 protein
  • MAF19_7 protein
  • mHDA1 protein
  • mHDA2 protein
  • mKIAA0600 protein
  • NY-CO-9 protein
  • Sfc6 protein

Protein level used designations for Histone Deacetylase 5 Proteins (HDAC5)

histone deacetylase 5 , antigen NY-CO-9 , HD5 , histone deacetylase 4 , histone deacetylase mHDA1 , histone deacetylase mHDA2 , scurfy candidate 6

100172968 Pongo abelii
10014 Homo sapiens
15184 Mus musculus
84580 Rattus norvegicus
490941 Canis lupus familiaris
504242 Bos taurus
100458256 Pongo abelii
100689350 Cricetulus griseus
836227 Arabidopsis thaliana
15185 Mus musculus
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