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Variant histone H2A which replaces conventional H2A in a subset of nucleosomes.
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Fruit Fly (Drosophila melanogaster) Polyclonal HIS2AV Primary Antibody for ELISA, WB - ABIN964669
Na, Park, Pyo, Lee, Jeon, Kim, Yoo: Mechanism of metformin: Inhibition of DNA damage and proliferative activity in Drosophila midgut stem cell. in Mechanisms of ageing and development 2013
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Fruit Fly (Drosophila melanogaster) Polyclonal HIS2AV Primary Antibody for ELISA, WB - ABIN129671
Shaukat, Liu, Choo, Hussain, OKeefe, Richards, Saint, Gregory: Chromosomal instability causes sensitivity to metabolic stress. in Oncogene 2014
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H2Av (show H2AFV Antibodies) or H3S10 phosphorylation by JIL-1 is not required for chromatin decondensation or transcriptional elongation in Drosophila.
The nucleosome positioning sequence (NPS (show NPS Antibodies)) patterns from H2A.Z (show H2AFZ Antibodies) nucleosomes differ from the NPS (show NPS Antibodies) patterns from H2A nucleosomes. The purine-purine/pyrimidine-pyrimidine pattern of H2A.Z (show H2AFZ Antibodies) nucleosomes has major peaks shifted by 10 bp deviated from the H2A nucleosome pattern. The H2A and H2A.Z (show H2AFZ Antibodies) nucleosomes have different sequence preferences.
the H2AZ (show H2AFZ Antibodies)-like rather than the H2AX (show H2AFX Antibodies)-like function of H2AV (show H2AFV Antibodies) is primarily required for normal hematopoiesis.
The study reports the crystal structure of the H2A.Z-binding domain of Drosophila melanogaster YL1 (dYL1-Z) in complex with an H2A.Z-H2B dimer at 1.9-A resolution.
The Drosophila histone variant H2A.V works in concert with HP1 (show CBX5 Antibodies) to promote kinetochore-driven microtubule formation.
nucleosomes present significant, context-specific barriers to RNAPII in vivo that can be tuned by the incorporation of H2A.Z (show H2AFZ Antibodies)
chromatin loosening and associated initiation of gene expression is activated by phosphorylation of H2Av (show H2AFV Antibodies) in a nucleosome positioned in promoter regions of PARP-1 (show PARP1 Antibodies)-dependent genes
Unlike other organisms that employ several H2A variants for different functions, the parsimonious fruit fly Drosophila melanogaster gets along with just a single H2A variant, H2A.V. Remarkably, H2A.V unites within one molecule features and functions of two different mammalian H2A variants, H2A.Z (show H2AFZ Antibodies) and H2A.X (show H2AFX Antibodies). [Review]
H2A.Z (show H2AFZ Antibodies) nucleosome occupancy has no effect on sequence variability of Drosophila genome
PARP1 (show PARP1 Antibodies) is targeted to chromatin by association with the histone H2A variant (H2Av).
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Acts as a Polycomb group (PcG) protein required to maintain the transcriptionally repressive state of homeotic genes of the animal throughout development. Required for histone H3 'Lys-9' methylation and histone H4 'Lys-12' acetylation, two modifications that are essential for heterochromatin formation. Also involved in DNA double strand break (DSB) repair. Essential for early development.
, H2A variant
, histone 2A variant
, histone H2A variant
, histone H2Av
, histone variant H2Av