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Histone-Lysine N-Methyltransferase MLL4 (MLL4) ELISA Kits

MLL4 encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. Additionally we are shipping Histone-Lysine N-Methyltransferase MLL4 Antibodies (33) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
MLL4 9757 Q9UMN6
MLL4 361543  
MLL4 75410 O08550
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Top Histone-Lysine N-Methyltransferase MLL4 ELISA Kits at antibodies-online.com

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Human
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$785.71
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Mouse
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More ELISA Kits for Histone-Lysine N-Methyltransferase MLL4 Interaction Partners

Human Histone-Lysine N-Methyltransferase MLL4 (MLL4) interaction partners

  1. The results explain how the MLL (show MLL ELISA Kits) SET domains of MLL1 and MLL4 (show MLL2 ELISA Kits) are able to add multiple methyl groups to the target histone H3 (show HIST3H3 ELISA Kits) lysine.

  2. The Aven (show AVEN ELISA Kits) RGG/RG motif bound G4 structures within the coding regions of the MLL1 and MLL4 (show MLL2 ELISA Kits) mRNAs increasing their polysomal association and translation, resulting in the induction of transcription of leukemic genes.

  3. We propose that MLL3 and MLL4 (show MLL2 ELISA Kits) are broadly required for controlling MAFA (show KLRG1 ELISA Kits) and MAFB (show MAFB ELISA Kits) transactivation during development and postnatally.

  4. HBV-MLL4 (show MLL2 ELISA Kits) integration occurred frequently in Chinese HCC (show FAM126A ELISA Kits) patients, representing a unique molecular segment for HCC (show FAM126A ELISA Kits) with HBV infection

  5. Chromosomal translocation in a pediatric undifferentiated spindle cell sarcoma have characterized this alteration to show rearrangement of the MLL4 (show MLL2 ELISA Kits) and GPS2 (show GPS2 ELISA Kits) genes, resulting in fusion gene MLL4 (show MLL2 ELISA Kits)-GPS2 (show GPS2 ELISA Kits), the expression of which promotes independent growth.

  6. KMT2B (show MLL2 ELISA Kits) transgene mediates hippocampal histone 3 lysine 4 di- and trimethylation and is a critical player for memory formation.

  7. the second PHD finger (PHD2) of MLL1 is an E3 ubiquitin ligase in the presence of the E2-conjugating enzyme CDC34. This activity is conserved in the second PHD finger of MLL4, the closest homolog to MLL1 but not in MLL2 or MLL3.

  8. knockdown of MLL4 (show MLL2 ELISA Kits) severely affects cell-cycle progression and induces apoptotic cell death in cultured tumour cells.

  9. Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2

  10. data suggest that the translocation breakpoint of MLL4 (show MLL2 ELISA Kits) gene is one of the preferential targets for HBV DNA integration into the MLL4 (show MLL2 ELISA Kits) gene and the HBV DNA integration may be involved in liver oncogenesis

Mouse (Murine) Histone-Lysine N-Methyltransferase MLL4 (MLL4) interaction partners

  1. Although enhancer priming by H3K4me1/2 methyltransferase MLL4/KMT2D (show MLL2 ELISA Kits) is dispensable for cell-identity maintenance, it controls cell fate transition by orchestrating p300 (show NOTCH1 ELISA Kits)-mediated enhancer activation

  2. KMT2D (show MLL2 ELISA Kits) is essential for regulating cardiac gene expression during heart development primarily via H3K4 di-methylation

  3. MLL2 interacts with RNA polymerase II (RNAPII) and RECQL5, and, although MLL2 mutated cells have normal overall H3K4me levels in genes, nucleosomes in the immediate vicinity of RNAPII are hypomethylated.

  4. MLL4 (KMT2D) is a major H3K4 mono- and di-methyltransferase with partial functional redundancy with MLL3 (KMT2C) in mouse and human cells. MLL4 is enriched on enhancers and is required for enhancer activation, cell-type-specific gene expression and cell differentiation.

  5. The results reveal a critical role for Mll2 in proliferation and cardiac lineage differentiation of mouse ESCs (show NR2E3 ELISA Kits), and provide novel molecular insight into the mechanisms of cardiac development and disease.

  6. Both MLL3 and MLL4 complexes act as major epigenetic regulators of diverse metabolic processes (including circadian control of bile acid homeostasis).

  7. Mll2, one of the six Set1/Trithorax-type H3K4 methyltransferases in mammals, is required for trimethylation of bivalent promoters in mouse embryonic stem cells, whereas Mll1 is redundant.

  8. results demonstrate that histone H3K4 methyltransferase Mll2 is a component of the genetic regulation necessary for glucose homeostasis, resulting in a specific disease pattern linking chromatin modification with causes and progression of type 2 diabetes

  9. Identify Mll2 (KMT2b) as the enzyme catalyzing H3K4 trimethylation at bivalently marked promoters in embryonic stem cells. Mll2 is required for H3K4 trimethylation at Homeobox (show PRRX1 ELISA Kits) gene clusters.

  10. Reexpression of KMT2B was sufficient to reinstate an active MagohB (show MAGOHB ELISA Kits) promoter.

Histone-Lysine N-Methyltransferase MLL4 (MLL4) Antigen Profile

Antigen Summary

This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known.

Gene names and symbols associated with MLL4

  • lysine (K)-specific methyltransferase 2B (KMT2B) antibody
  • lysine (K)-specific methyltransferase 2B (Kmt2b) antibody
  • lysine (K)-specific methyltransferase 2D (Kmt2d) antibody
  • myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4) antibody
  • myeloid/lymphoid or mixed-lineage leukemia 4 (LOC100353483) antibody
  • 2610014H22Rik antibody
  • ALR antibody
  • BC032281 antibody
  • BC058659 antibody
  • C430014K11Rik antibody
  • HRX2 antibody
  • KMT2B antibody
  • mKIAA0304 antibody
  • MLL1B antibody
  • Mll2 antibody
  • Mll4 antibody
  • RGD1308331 antibody
  • TRX2 antibody
  • Wbp7 antibody

Protein level used designations for MLL4

KMT2D , WBP-7 , WW domain binding protein 7 , WW domain-binding protein 7 , histone-lysine N-methyltransferase 2B , histone-lysine N-methyltransferase MLL4 , lysine N-methyltransferase 2B , lysine N-methyltransferase 2D , mixed lineage leukemia gene homolog 2 , myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4 , myeloid/lymphoid or mixed-lineage leukemia 4 , myeloid/lymphoid or mixed-lineage leukemia protein 4 , trithorax homolog 2 , trithorax homologue 2 , mixed lineage leukemia 2 , myeloid/lymphoid or mixed-lineage leukemia protein 4 homolog , ALL1-related protein , histone-lysine N-methyltransferase 2D , histone-lysine N-methyltransferase MLL2 , myeloid/lymphoid or mixed-lineage leukemia 2 , myeloid/lymphoid or mixed-lineage leukemia protein 2

GENE ID SPECIES
9757 Homo sapiens
361543 Rattus norvegicus
75410 Mus musculus
381022 Mus musculus
100688666 Canis lupus familiaris
100353483 Oryctolagus cuniculus
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