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Holliday Junction Recognition Protein Proteins (HJURP)

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Additionally we are shipping HJURP Antibodies (35) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HJURP 381280 Q6PG16
HJURP 55355 Q8NCD3
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Top HJURP Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details

HJURP Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human
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More Proteins for Holliday Junction Recognition Protein (HJURP) Interaction Partners

Mouse (Murine) Holliday Junction Recognition Protein (HJURP) interaction partners

  1. Study showed major differences in gene copy number in natural populations. CWC22 (show CWC22 Proteins), SFI1 (show SFI1 Proteins), and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations.

Human Holliday Junction Recognition Protein (HJURP) interaction partners

  1. Authors propose that this centromere expansion activity reflects the functional properties of HJURP, which uses this activity to contribute to the plastic establishment of a centromeric chromatin structure.

  2. 3 biomarkers in 44 patients with in situ breast cancers were evaluated: TG2 (transglutaminase 2 (show TGM2 Proteins)), HJURP (Holliday junction recognition protein), and HIF-1alpha (hypoxia inducible factor-1 alpha (show HIF1A Proteins)).

  3. On the basis of our findings, we propose that HJURP serves a dual chaperone function in coordinating CenH3(CENP-A (show CENPA Proteins)) and CENP-C recruitment.

  4. HJURP can discriminate favorable and unfavorable outcome within the luminal A subtype, outperforming the currently utilized proliferation marker Ki67 (show MKI67 Proteins), as an independent prognostic marker for luminal A patients.

  5. Phosphorylation state of HJURP controls its centromeric recruitment. HJURP binding to DNA promotes loading of CenH3CENP-A at centromeres.

  6. The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP and CENP-A (show CENPA Proteins), implicating RNA-based chaperone targeting in histone variant assembly.

  7. The levels of the EDNRB (show EDNRB Proteins), HJURP and p60/CAF-1 (show CHAF1B Proteins) proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 (show PDLIM4 Proteins) was not (P=0.11).

  8. Mis18beta (show OIP5 Proteins) binds with and specifies the centromere localization of HJURP.

  9. HJURP has an important role in the maintenance of extremely proliferative cells of high-grade gliomas

  10. a mechanism whereby the CENP-A (show CENPA Proteins) pre-nucleosomal complex achieves assembly of the octameric CENP-A (show CENPA Proteins) nucleosome through the dimerization of the CENP-A (show CENPA Proteins) chaperone HJURP.

HJURP Protein Profile

Protein Summary

Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions (By similarity).

Gene names and symbols associated with HJURP

  • Holliday junction recognition protein (Hjurp)
  • Holliday junction recognition protein (HJURP)
  • C330011F01Rik protein
  • FAKTS protein
  • Gm975 protein
  • hFLEG1 protein
  • Mfleg1 protein
  • MGC66590 protein
  • URLC9 protein

Protein level used designations for HJURP

Holliday junction recognition protein , OTTMUSP00000022762 , OTTMUSP00000038458 , fetal liver expressing gene 1 protein homolog , 14-3-3-associated AKT substrate , fetal liver expressing gene 1 , fetal liver-expressing gene 1 protein , up-regulated in lung cancer 9

GENE ID SPECIES
381280 Mus musculus
55355 Homo sapiens
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