Use your antibodies-online credentials, if available.
No Products on your Comparison List.
Your basket is empty.
Find out more
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Additionally we are shipping HJURP Proteins (6) and and many more products for this protein.
Showing 10 out of 40 products:
Human Polyclonal HJURP Primary Antibody for ICC, IF - ABIN4318544
Shuaib, Ouararhni, Dimitrov, Hamiche: HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres. in Proceedings of the National Academy of Sciences of the United States of America 2010
Show all 3 Pubmed References
Study showed major differences in gene copy number in natural populations. CWC22 (show CWC22 Antibodies), SFI1 (show SFI1 Antibodies), and HJURP are highly conserved genes with the most copy-number variation. They all exhibit population-specific expansion patterns, perhaps for local adaptations.
Functional p53 (show TP53 Antibodies) elicits a cell cycle arrest response, whereas, in p53 (show TP53 Antibodies)-null transformed cells, the absence of arrest enables the loss of HJURP to induce severe aneuploidy and, ultimately, apoptotic cell death
Authors propose that this centromere expansion activity reflects the functional properties of HJURP, which uses this activity to contribute to the plastic establishment of a centromeric chromatin structure.
3 biomarkers in 44 patients with in situ breast cancers were evaluated: TG2 (transglutaminase 2 (show TGM2 Antibodies)), HJURP (Holliday junction recognition protein), and HIF-1alpha (hypoxia inducible factor-1 alpha (show HIF1A Antibodies)).
On the basis of our findings, we propose that HJURP serves a dual chaperone function in coordinating CenH3(CENP-A (show CENPA Antibodies)) and CENP-C (show CENPC1 Antibodies) recruitment.
HJURP can discriminate favorable and unfavorable outcome within the luminal A subtype, outperforming the currently utilized proliferation marker Ki67 (show MKI67 Antibodies), as an independent prognostic marker for luminal A patients.
Phosphorylation state of HJURP controls its centromeric recruitment. HJURP binding to DNA promotes loading of CenH3CENP-A at centromeres.
The study describes a novel function for human centromeric long non-coding RNAs in the recruitment of HJURP and CENP-A (show CENPA Antibodies), implicating RNA-based chaperone targeting in histone variant assembly.
The levels of the EDNRB (show EDNRB Antibodies), HJURP and p60/CAF-1 (show CHAF1B Antibodies) proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 (show PDLIM4 Antibodies) was not (P=0.11).
Mis18beta (show OIP5 Antibodies) binds with and specifies the centromere localization of HJURP.
HJURP has an important role in the maintenance of extremely proliferative cells of high-grade gliomas
Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions (By similarity).
Holliday junction recognition protein
, fetal liver expressing gene 1 protein homolog
, 14-3-3-associated AKT substrate
, fetal liver expressing gene 1
, fetal liver-expressing gene 1 protein
, up-regulated in lung cancer 9