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Holocytochrome C Synthase Proteins (HCCS)

The protein encoded by HCCS is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Additionally we are shipping Holocytochrome C Synthase Antibodies (78) and Holocytochrome C Synthase Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HCCS 3052 P53701
Rat HCCS HCCS 317444  
HCCS 15159 P53702
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Top Holocytochrome C Synthase Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,713.33
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,718.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HCCS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Holocytochrome C Synthase (HCCS) Interaction Partners

Human Holocytochrome C Synthase (HCCS) interaction partners

  1. cysteines and histidine of the heme attachment site, Cys (show DNAJC5 Proteins)-XX-Cys (show DNAJC5 Proteins)-His play a key role in mitochondrial holocytochrome c synthase

  2. These data indicate that heme contacts mediated by residues within these domains modulate the dynamics of heme binding and contribute to the stability of the HCCS-heme-cytochrome c (show CYCS Proteins) steady state ternary complex.

  3. Identification of a deletion in two patients, including HCCS, leads to the diagnosis of microphthalmia with linear skin defects syndrome

  4. Spectroscopic analyses of HCCS alone and complexes of HCCS with site-directed variants of cytochrome c (show CYCS Proteins) revealed the fundamental steps of heme attachment and maturation.

  5. Through the study of genetically engineered mice, the loss of HCCS is demonstrated to cause the male lethality of microphthalmia with linear skin defects (MLS) syndrome.

  6. mutant proteins (R217C and Delta 197-268) were unable to complement a Saccharomyces cerevisiae mutant deficient for the HCCS orthologue Cyc3p, in contrast to wild-type HCCS

  7. Missense mutation p.E159K of HCCS, leading to loss-of-function of encoded holocytochrome c-type synthase, in female with microphthalmia of both eyes and bilateral sclerocornea may suggest HCCS as candidate for severe ocular manifestations.

Mouse (Murine) Holocytochrome C Synthase (HCCS) interaction partners

  1. Analysis of Mid1 (show MID1 Proteins), Hccs, Arhgap6 (show ARHGAP6 Proteins), and Msl3l1 (show MSL3 Proteins) in X-linked polydactyly (Xpl) and Patchy-fur (Paf (show KIAA0101 Proteins)) mutant mice

Holocytochrome C Synthase (HCCS) Protein Profile

Protein Summary

The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene.

Gene names and symbols associated with HCCS

  • holocytochrome c synthase (hccs)
  • cytochrome c heme-lyase (cchl)
  • holocytochrome c synthase (HCCS)
  • holocytochrome c synthase (Hccs)
  • holocytochrome c synthase-like (LOC100356413)
  • holocytochrome c synthetase (Hccs)
  • CCHL protein
  • DDBDRAFT_0217711 protein
  • DDBDRAFT_0266707 protein
  • DDB_0217711 protein
  • DDB_0266707 protein
  • hccsb protein
  • id:ibd1278 protein
  • MCOPS7 protein
  • RGD1563855 protein
  • wu:fb18h01 protein
  • wu:fc64e12 protein
  • wu:fi43e01 protein

Protein level used designations for HCCS

cytochrome c-type heme lyase , holocytochrome c synthetase b , holocytochrome c synthase (cytochrome c heme-lyase) , holocytochrome c synthase , cytochrome c heme-lyase , holocytochrome c-type synthase , holocytochrome c synthetase , CCHL

GENE ID SPECIES
58016 Danio rerio
448226 Xenopus (Silurana) tropicalis
8620147 Dictyostelium discoideum AX4
3052 Homo sapiens
317444 Rattus norvegicus
506250 Bos taurus
424482 Gallus gallus
480834 Canis lupus familiaris
100356413 Oryctolagus cuniculus
15159 Mus musculus
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