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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping HOXA10 Antibodies (64) and HOXA10 Kits (13) and many more products for this protein.
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Regulated HOXA10 and HOXA11 (show HOXA11 Proteins) expression is necessary for endometrial receptivity; decreased HOXA10 or HOXA11 (show HOXA11 Proteins) expression leads to decreased implantation rates. Alternation of HOXA10 and HOXA11 (show HOXA11 Proteins) expression has been identified as a mechanism of the decreased implantation associated with endometriosis, polycystic ovarian syndrome, leiomyoma, polyps, adenomyosis, and hydrosalpinx.
The combinatory expression of HOXA10 and CD44 (show CD44 Proteins) was correlated with poor gastric cancer prognosis.
confirmed that HOXA10 promoted epithelialmesenchymal transition in ovarian cancer cells
Promoter activity of HOXA10 lies in 5.3-6.1 kb upstream of protein coding region.CTCF negatively regulates HOXA10 expression in breast cancer cells.CTCF flanks important promoter element of HOXA10.
The results showed overexpression of HOXA10 mRNA and protein in Ishikawa cell.
HOXA10 is expressed in rectosigmoid endometriosis, where it likely imparts the de novo identity of endometriotic lesions.
miR (show MLXIP Proteins)-494 repressed the expression of HOXA10 and also reduced the proliferation of oral cancer cells. These data give more evidence of the role of miR (show MLXIP Proteins)-494 as a tumor suppressor miRNA in oral cancer.
Peri (show PLIN1 Proteins)-implantation HOXA-10 mRNA expression is increased following laparoscopic endometrioma resection.
the CpG island of the HOXA10 alternative promoter appears to escape hypermethylation in the HOX (show MSH2 Proteins)-high glioblastoma.
Data show that recruitment of MLL1 (mixed lineage leukaemia histone methylase 1) to the homeobox (show Lbx1 Proteins)-containing gene HOXA10 EREs (estrogen response elements) is mediated via ERalpha (estrogen receptor alpha (show ESR1 Proteins)).
study identified an E(2)/P(4) response element of the porcine HOXA10 gene for the first time
investigation of regulation of HOXA10 gene expression by estradiol and/or progesterone in porcine endometrium during estrous.
Homeobox A10 expression in the porcine endometrium is closely related to the implantation process and stimulated by conceptus products.
we suggest that proper regional decidualization and polyploidy development requires FoxM1 (show FOXM1 Proteins) signaling downstream of Hoxa10 and cyclin D3 (show CCND3 Proteins).
these studies demonstrate a previously undescribed role for HoxA10 in terminating emergency granulopoiesis, suggesting an important contribution by Hox (show MSH2 Proteins) proteins to the innate immune response.
Hoxa10 cooperates with Nkx2-5 (show NKX2-5 Proteins) to regulate the timing of cardiac mesoderm differentiation.
results show that reduced APC activity is sufficient to induce formation of epithelial inclusion cysts and support ovarian endometrioid adenocarcinoma development and suggest that induced HOXA10 expression and loss of PTEN are key mechanisms driving endometrioid histotype differentiation and progression
a molecular mechanisms through which increased expression of HoxA10 increases Cdx4 expression by direct CDX4 activation and by Fgf2 (show FGF2 Proteins)-induced beta-catenin (show CTNNB1 Proteins) activity. This results in Cdx4-induced HoxA10-expression, creating a positive feedback mechanism
Setbp1 (show SETBP1 Proteins) promotes the self-renewal of murine myeloid progenitors via activation of Hoxa9 (show HOXA9 Proteins) and Hoxa10.
found that increased Fgf2 (show FGF2 Proteins) production by HoxA10-overexpressing myeloid progenitor cells induced a phosphoinositol 3-kinase-dependent increase in beta-catenin (show CTNNB1 Proteins) protein
Results suggest that maternal obesity impairs fetal skeletal development through down-regulation of the HoxA10 gene, which may lead to an increase in the prevalence of low bone mass in the offspring later in life.
Data show that the extra-embryonic function of Hoxa10, -11, and -13 genes stems from their specific expression in the allantois, an extra-embryonic hallmark of amniote vertebrates.
PBX1 (show PBX1 Proteins) plays a central role in attenuating the activity of HOXA10 as an activator of osteoblast-related genes.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene.
, homeobox A10, isoform 1
, homeobox protein Hox-A10-like
, homeo box A10
, homeobox protein 1H
, homeobox protein HOXA10
, homeobox protein Hox-1.8
, homeobox protein Hox-1H
, homeobox protein Hox-A10
, homeobox protein A10