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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping HOXA5 Antibodies (116) and HOXA5 Proteins (11) and many more products for this protein.
ATRA may inhibit the proliferation of K562 cells and promote apoptosis by upregulating the HOXA5 mRNA and protein expression.
Knockdown of HOXA5 suppressed the proliferation and metastasis of esophageal squamous cell cancer cells.
high expression levels of HOXA5 mRNA and protein in children with ALL indicate that HOXA5 is closely associated with childhood ALL.
Downregulation of HOXA5 by shRNA may trigger apoptosis and overcome drug resistance in leukemia cells.
HOXA5-induced apoptosis was p53 (show TP53 ELISA Kits)-independent.
Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3 (show KLF3 ELISA Kits), contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review)
In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis.
Ectopic expression of HOXA5 in highly invasive cancer cells suppressed cell migration, invasion, and filopodia formation in vitro and inhibited metastatic potential in vivo.
The NK AML (show RUNX1 ELISA Kits) patients with NPM1 (show NPM1 ELISA Kits) mutations exhibited elevated HOXA4 (show HOXA4 ELISA Kits) methylation and expression levels of HOXA5 and MEIS1 (show MEIS1 ELISA Kits) compared with the NPM1 (show NPM1 ELISA Kits) wildtype patients.
Increased expression of HOXA5 is associated with acute myeloid leukemia (show BCL11A ELISA Kits).
In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (show HOXA1 ELISA Kits), HoxA5, HoxC4 (show HOXC4 ELISA Kits) &HoxC8 (show HOXC8 ELISA Kits) markedly enhanced. Irrespective of presence or absence of T3, insulin (show INS ELISA Kits) down regulates HoxA10 (show HOXA10 ELISA Kits). T3 results in over expression of HoxA5, HoxC4 (show HOXC4 ELISA Kits) and HoxC8 (show HOXC8 ELISA Kits) genes, whereas insulin (show INS ELISA Kits) up regulates expression of only HoxC8 (show HOXC8 ELISA Kits)
Methylation profiling of HoxA5 gene promoter shows higher methylation in adult as compared to fetus in various somatic tissues of mouse being highest in adult spleen. However q-PCR results show higher expression during fetal stages being highest in fetal intestine followed by brain, liver and spleen. These results clearly indicate a strict correlation between DNA methylation (show HELLS ELISA Kits) and tissue-specific gene expression.
HoxA5 represents a novel molecule for restricting pathological and tumorigenic angiogenesis.
Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo.
YY1 (show YY1 ELISA Kits) acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.
Hoxa5 and Hoxb5 (show HOXB5 ELISA Kits) paralog genes share some functions during lung morphogenesis; Hoxa5 plays a predominant role.
Two Hox (show MSH2 ELISA Kits) genes, Hoxa5 and Hoxc5 (show HOXC5 ELISA Kits), control diverse aspects of phrenic motor column development.
Hoxa5, a stroma-specific gene, plays a significant role in ovarian biology and may be involved in ovarian cancer predisposition
Hoxa5 larger transcripts may participate in the control of Hox (show MSH2 ELISA Kits) gene expression.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
, homeo box A5
, similar to Homeobox protein Hox-A5 (Hox-1.3) (M2)
, hoxa5a protein
, homeobox protein Hox-1.3
, homeobox protein Hox-A5
, homeo box 1C
, homeobox protein HOXA5
, homeobox protein Hox-1C
, homeobox protein M2
, Homeobox protein Hox-A5