Homeobox A5 Proteins (HOXA5)

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping HOXA5 Antibodies (117) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HOXA5 79241  
HOXA5 3202 P20719
HOXA5 15402 P09021
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Top HOXA5 Proteins at antibodies-online.com

Showing 10 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Yeast Sheep His tag   1 mg Log in to see 60 to 71 Days
$2,016.67
Details
Yeast REACT_Atlantic Salmon His tag   1 mg Log in to see 60 to 71 Days
$2,106.50
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,588.67
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,704.17
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Yeast Primate His tag   1 mg Log in to see 60 to 71 Days
$2,704.17
Details
Yeast REACT_Woolly monkey His tag   1 mg Log in to see 60 to 71 Days
$2,704.17
Details
Yeast Heterodontus francisci His tag   1 mg Log in to see 60 to 71 Days
$2,718.83
Details

HOXA5 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
,
Mouse (Murine)

More Proteins for Homeobox A5 (HOXA5) Interaction Partners

Human Homeobox A5 (HOXA5) interaction partners

  1. loss of HOXA5 in mammary cells leads to loss of epithelial traits, an increase in stemness and cell plasticity, and the acquisition of more aggressive phenotypes.

  2. ATRA may inhibit the proliferation of K562 cells and promote apoptosis by upregulating the HOXA5 mRNA and protein expression.

  3. Knockdown of HOXA5 suppressed the proliferation and metastasis of esophageal squamous cell cancer cells.

  4. high expression levels of HOXA5 mRNA and protein in children with ALL indicate that HOXA5 is closely associated with childhood ALL.

  5. Downregulation of HOXA5 by shRNA may trigger apoptosis and overcome drug resistance in leukemia cells.

  6. HOXA5-induced apoptosis was p53 (show TP53 Proteins)-independent.

  7. Among the mechanosensitive genes, the two transcription factors, HoxA5 and Klf3 (show KLF3 Proteins), contain cAMP-response-elements methylation of which could serve as a mechanosensitive master switch in gene expression in atherosclerosis. (Review)

  8. In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis.

  9. Ectopic expression of HOXA5 in highly invasive cancer cells suppressed cell migration, invasion, and filopodia formation in vitro and inhibited metastatic potential in vivo.

  10. The NK AML (show RUNX1 Proteins) patients with NPM1 (show NPM1 Proteins) mutations exhibited elevated HOXA4 (show HOXA4 Proteins) methylation and expression levels of HOXA5 and MEIS1 (show MEIS1 Proteins) compared with the NPM1 (show NPM1 Proteins) wildtype patients.

Mouse (Murine) Homeobox A5 (HOXA5) interaction partners

  1. In presence of these inducing agents, lipid accumulation as well as expression of HoxA1 (show HOXA1 Proteins), HoxA5, HoxC4 (show HOXC4 Proteins) &HoxC8 (show HOXC8 Proteins) markedly enhanced. Irrespective of presence or absence of T3, insulin (show INS Proteins) down regulates HoxA10 (show HOXA10 Proteins). T3 results in over expression of HoxA5, HoxC4 (show HOXC4 Proteins) and HoxC8 (show HOXC8 Proteins) genes, whereas insulin (show INS Proteins) up regulates expression of only HoxC8 (show HOXC8 Proteins)

  2. Methylation profiling of HoxA5 gene promoter shows higher methylation in adult as compared to fetus in various somatic tissues of mouse being highest in adult spleen. However q-PCR results show higher expression during fetal stages being highest in fetal intestine followed by brain, liver and spleen. These results clearly indicate a strict correlation between DNA methylation (show HELLS Proteins) and tissue-specific gene expression.

  3. In colon cancer, HOXA5 is downregulated, and its re-expression induces loss of the cancer stem cell phenotype, preventing tumor progression and metastasis.

  4. HoxA5 represents a novel molecule for restricting pathological and tumorigenic angiogenesis.

  5. Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo.

  6. YY1 (show YY1 Proteins) acts as a transcriptional activator of Hoxa5 gene expression in mouse organogenesis.

  7. Hoxa5 and Hoxb5 (show HOXB5 Proteins) paralog genes share some functions during lung morphogenesis; Hoxa5 plays a predominant role.

  8. Two Hox (show MSH2 Proteins) genes, Hoxa5 and Hoxc5 (show HOXC5 Proteins), control diverse aspects of phrenic motor column development.

  9. Hoxa5, a stroma-specific gene, plays a significant role in ovarian biology and may be involved in ovarian cancer predisposition

  10. Hoxa5 larger transcripts may participate in the control of Hox (show MSH2 Proteins) gene expression.

HOXA5 Protein Profile

Protein Summary

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.

Gene names and symbols associated with Homeobox A5 Proteins (HOXA5)

  • homeobox A5 (HOXA5)
  • homeobox A5 (hoxa5)
  • similar to Homeobox protein Hox-A5 (Hox-1.3) (M2) (HOXA5)
  • hoxa5a protein (hoxa5a)
  • homeo box A5 (Hoxa5)
  • homeobox A5 (Hoxa5)
  • Hox-1.3 protein
  • HOX1 protein
  • HOX1.3 protein
  • HOX1C protein
  • HOXA-5 protein
  • HOXA5 protein

Protein level used designations for Homeobox A5 Proteins (HOXA5)

homeobox A5 , homeo box A5 , similar to Homeobox protein Hox-A5 (Hox-1.3) (M2) , hoxa5a protein , homeobox protein Hox-1.3 , homeobox protein Hox-A5 , hox-1.3 , homeo box 1C , homeobox protein HOXA5 , homeobox protein Hox-1C , homeobox protein M2 , Homeobox protein Hox-A5

GENE ID SPECIES
482370 Canis lupus familiaris
463310 Pan troglodytes
496880 Xenopus (Silurana) tropicalis
100137361 Papio anubis
700221 Macaca mulatta
100049201 Oryzias latipes
79241 Rattus norvegicus
3202 Homo sapiens
15402 Mus musculus
100858404 Gallus gallus
100499568 Sus scrofa
768039 Bos taurus
443358 Ovis aries
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