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HOXB13 encodes a transcription factor that belongs to the homeobox gene family. Additionally we are shipping HOXB13 Antibodies (65) and many more products for this protein.
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Cdx (show CDX1 Proteins) and Wnt (show WNT2 Proteins) mutations and premature Hox13 (show HOXA5 Proteins) expression also cause similar neural dysmorphology
Hoxb13 has a negative effect on skin wound repair
Data demonstrate that FOXA1 (show FOXA1 Proteins) directly regulates HOXB13 in human prostate epithelial cells, and show that this prostate-specific (show KLK3 Proteins) regulatory mechanism is conserved in mice.
results suggest a specific role for Hoxb13 in a differentiation pathway that gives the ventral prostate epithelium a unique identity, as well as a more general role in ventral prostate morphogenesis that is redundant with other Hox13 (show HOXA5 Proteins) paralogs
Hoxb13 knockout mice exhibit enhanced cutaneous wound healing.
Epidermal HOXB13 signal was detected over the entire body surface, but surprisingly, essentially all of the signal was cytoplasmic in developing skin
An increase of the Ala repeat above a certain length (22 Ala)in the Hoxd13 (show HOXD13 Proteins) sequence, resulting in synpolydactyly, is associated with a shift in the localization of Hox13 (show HOXA5 Proteins) from nuclear to cytoplasmic and aggregation.
Hoxb13 cis (show CISH Proteins)-regulatory elements provide a powerful tool to achieve androgen-independent transgene expression in the prostate and distal colon-specific expression in the gastrointestinal tract
Studies indicate that the germline homeo box B13 protein (HOXB13) p.Gly84Glu mutation is significantly increased the risk of cancers.
review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer
Recent studies have shown that HOXB13 is a strong candidate for familial Prostate cancer gene.
The strongest predictors are the BRCA2 (show BRCA2 Proteins) mutations, and the highly penetrant G84E mutation in HOXB13
We showed for the first time that HOXB13 is a sensitive and specific marker for detection of prostatic origin in distant metastases.
The associations between HOXB13 and prostate, leukemia, and bladder suggest that this gene is important in carcinogenesis.
Hoxb-13 overexpression is correlated with tumor angiogenesis, aberrant expression of EMT (show ITK Proteins)-associated markers and aggressive clinicopathological characteristics in pancreatic carcinoma.
The prevalence of somatic HOXB13 mutations in prostate cancer.
Our results show that HOXB13/SLUG (show SNAI2 Proteins) and ALX4 (show ALX4 Proteins)/SLUG (show SNAI2 Proteins) axes are novel pathways that promote EMT (show ITK Proteins) and invasion of ovarian cancer cells.
our study highlights HOXB13 as strong and independent prognostic marker in prostate cancer
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.
, homeo box B13
, homeobox protein Hox-B13