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HOXB13 encodes a transcription factor that belongs to the homeobox gene family. Additionally we are shipping HOXB13 Antibodies (72) and HOXB13 Proteins (5) and many more products for this protein.
Cdx (show CDX1 ELISA Kits) and Wnt (show WNT2 ELISA Kits) mutations and premature Hox13 (show HOXA5 ELISA Kits) expression also cause similar neural dysmorphology
Hoxb13 has a negative effect on skin wound repair
Data demonstrate that FOXA1 directly regulates HOXB13 in human prostate epithelial cells, and show that this prostate-specific regulatory mechanism is conserved in mice.
results suggest a specific role for Hoxb13 in a differentiation pathway that gives the ventral prostate epithelium a unique identity, as well as a more general role in ventral prostate morphogenesis that is redundant with other Hox13 (show HOXA5 ELISA Kits) paralogs
Hoxb13 knockout mice exhibit enhanced cutaneous wound healing.
Epidermal HOXB13 signal was detected over the entire body surface, but surprisingly, essentially all of the signal was cytoplasmic in developing skin
An increase of the Ala repeat above a certain length (22 Ala)in the Hoxd13 (show HOXD13 ELISA Kits) sequence, resulting in synpolydactyly, is associated with a shift in the localization of Hox13 (show HOXA5 ELISA Kits) from nuclear to cytoplasmic and aggregation.
Hoxb13 cis (show CISH ELISA Kits)-regulatory elements provide a powerful tool to achieve androgen-independent transgene expression in the prostate and distal colon-specific expression in the gastrointestinal tract
HOXB13 mutation is associated with prostate tumors.
CCAT1 regulates HOXB13 as a molecular decoy for miR-7 (show LILRB1 ELISA Kits), a microRNA that targets both CCAT1 and HOXB13, thus facilitating cell growth and migration in esophageal squamous cell carcinoma
This study presents in silico prediction approaches of the deleterious ns single nucleotide polymorphisms (missense) in the homeobox (show Lbx1 ELISA Kits) domain of human HOXB13 gene responsible for hereditary prostate cancer.
This is the first study to investigate the HOXB13 G84E mutation in Danish men. The mutation was detected in 0.49% of controls and in 2.51% of cases, and was associated with 5.12-fold increased relative risk of being diagnosed with prostate cancer. In our RP cohort, HOXB13 mutation carriers were more likely to develop aggressive prostate cancer.
HOXB13 is a useful marker for prostate origin when doubt exists regarding the site of the primary of a metastatic lesion
Tumor-associated macrophage-secreted CXCL8 (show IL8 ELISA Kits) downregulated the ERalpha (show ESR1 ELISA Kits) expression of endometrial cancer cells via HOXB13, which may be associated with cancer invasion, metastasis and poor prognosis.
Study provides insights suggesting that HOXB13 plays an important role in prostate tumorigenesis and malignant progression via the regulation of both p21 (show CDKN1A ELISA Kits) and JNK (show MAPK8 ELISA Kits) signaling.
The Breast Cancer Index (BCI) is a continuous risk index model of two previously described biomarkers: molecular grade index (MGI) and HOXB13:IL17BR (H:I) ratio
Studies indicate that the germline homeo box B13 protein (HOXB13) p.Gly84Glu mutation is significantly increased the risk of cancers.
review the functions attributed to HOXB13, by highlighting the most recent findings supporting the hypothesis that HOXB13 might serve as a novel biomarker for the prognosis of prostate cancer
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated to play a role in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster at chromosome the 17q21-22 region.
, homeo box B13
, homeobox protein Hox-B13