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HOXC6 belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Additionally we are shipping Homeobox C6 Antibodies (59) and Homeobox C6 Proteins (8) and many more products for this protein.
Increased expression of HOXC6 in gastric cancer cell lines significantly activated extracellular signalregulated kinase signaling and upregulated MMP9 (show MMP9 ELISA Kits). The HOXC6 gene promotes the proliferation of gastric cancer cells while upregulation of MMP9 (show MMP9 ELISA Kits) promotes migration and invasion of gastric cancer cells.
oxidized low-density lipoprotein (Ox-LDL) decreased expression of HOXC-AS1 (show PTGDR ELISA Kits) and HOXC6 in a time-dependent manner
HOXC6 has a role in all prostate cancer stages, particularly in prostate cancer cell proliferation.
Data demonstrate significant downregulation of HOXC6 in serous ovarian cancer and low protein level is associated with high-grade tumors.
Our studies demonstrate that HOXC6, which is a critical player in mammary gland development, is upregulated in multiple cases of breast cancer, and is transcriptionally regulated by E2 and BPA (show DST ELISA Kits), in vitro and in vivo.
HOXC6 can be used as a prognostic marker in esophageal squamous cell carcinoma
HOXC6 expression is an important mechanism of chemotherapeutic drug resistance via its regulation of MDR-1
Hoxc6 might contribute to the progression of gastric carcinogenesis and may be a significant predictor of poor survival in patients with gastric cancer after curative operations.
HOXC6 is an important mechanism of the anti-apoptotic pathway via regulation of Bcl-2 (show BCL2 ELISA Kits) expression.
These studies demonstrated that HOXC6 is an estrogen-responsive gene, and that histone methylases MLL2 (show MLL2 ELISA Kits) and MLL3, in coordination with ERalpha (show ESR1 ELISA Kits) and ERbeta (show ESR2 ELISA Kits), transcriptionally regulate HOXC6 in an estrogen-dependent manner.
results demonstrate that HOXC6 acts as a regulator in hematopoiesis and is involved in malignant transformation
Hoxc6 functions are not restricted to the expected role in anterior-posterior pattern formation, but they also regulate N-tubulin (show TUBB2C ELISA Kits), thereby having an effect on the initial formation of primary neurons in Xenopus laevis embryos
This gene belongs to the homeobox family, members of which encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene, HOXC6, is one of several HOXC genes located in a cluster on chromosome 12. Three genes, HOXC5, HOXC4 and HOXC6, share a 5' non-coding exon. Transcripts may include the shared exon spliced to the gene-specific exons, or they may include only the gene-specific exons. Alternatively spliced transcript variants encoding different isoforms have been identified for HOXC6. Transcript variant two includes the shared exon, and transcript variant one includes only gene-specific exons.
, homeobox c6a
, homeobox gene C-6
, homeobox protein Hox-C6a
, homeobox protein Zf-61
, similar to homeobox A6
, homeobox C6
, homeo box 3C
, homeo box C6
, homeo box C8 protein
, homeobox protein CP25
, homeobox protein HHO.C8
, homeobox protein Hox-3C
, homeobox protein Hox-C6
, homeobox protein Hox-3.3
, homeobox protein Hox-6.1
, Antennapedia-type homeotic factor
, XlHbox1 PR II type
, homeo box protein
, homeobox protein Hoxc-6