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HOXD11 belongs to the homeobox family of genes. Additionally we are shipping Homeobox D11 Antibodies (60) and Homeobox D11 Proteins (6) and many more products for this protein.
High expression of HOXD11 is associated with laryngeal squamous cell carcinoma.
POU2F1 (show POU2F1 ELISA Kits) activity regulates HOXD10 (show HOXD10 ELISA Kits) and HOXD11 gene expression in head and neck squamous cell carcinoma, promoting a proliferative and invasive phenotype.
data show no significant difference in HOXD11, HOXD12 (show HOXD12 ELISA Kits) & HOXD13 (show HOXD13 ELISA Kits) genotype frequencies between the autism spectrum disorder & healthy controls, but one SNP in promoter region of HOXD11 was observed in only 4 patients with ASD (show ARSD ELISA Kits)
In human embryonic stem cell (hESCs)differentiation, a 1.8kb region between HOXD11 and HOXD12 (show HOXD12 ELISA Kits) (D11.12) that is associated with PcG proteins was discovered, it shows alteration in nuclease (show DCLRE1C ELISA Kits) sensitivity as hESCs differentiate.
The HOXD11 gene is fused to the NUP98 (show NUP98 ELISA Kits) gene in acute myeloid leukemia (show BCL11A ELISA Kits) with t(2;11)(q31;p15 (show CDKN2B ELISA Kits)).
Our findings do not support the hypothesis that mutations in the HOXD11 coding regions are involved in the pathogenesis of human non-syndromal congenital renal parenchymal malformations.
expressed adjacent to the pisiform in late-stage embryonic limbs, supporting a role for Hox (show MSH2 ELISA Kits) genes in growth plate specification
Hoxa11 (show HOXA11 ELISA Kits) and Hoxd11 regulate chondrocyte differentiation upstream of Runx2 (show RUNX2 ELISA Kits) and Shox2 (show SHOX2 ELISA Kits) in mice.
Hox11 (show TLX1 ELISA Kits) genes (Hoxa11 (show HOXA11 ELISA Kits), Hoxc11 (show HOXC11 ELISA Kits) and Hoxd11) co-regulate and coordinate the development of zeugopod skeletal elements and adjacent elbow and knee joints, and dictate joint identity, morphogenesis and anatomical and functional organization.
mice individually mutant for Hoxa11 (show HOXA11 ELISA Kits) or Hoxd11 show no discernible kidney abnormalities. Hoxa11 (show HOXA11 ELISA Kits)/Hoxd11 double mutants, however, demonstrate hypoplasia of the kidneys
analysis of the Hoxd11 duplication demonstrated that the Hoxd11 can perform some functions supplied by its paralogue Hoxa11 (show HOXA11 ELISA Kits), the defects in forelimb bones are corrected when extra copies of Hoxd11 are present in the Hoxa11 (show HOXA11 ELISA Kits) homozygous mutant background
malformation of the forelimb zeugopod in Hoxa11 (show HOXA11 ELISA Kits)/Hoxd11 double mutants is a consequence of interruption at multiple steps during the formation of the radius and ulna
early posterior restriction of Hox (show MSH2 ELISA Kits) gene products sets up an anterior-posterior prepattern, which determines the localized activation of Shh (show SHH ELISA Kits); this signal is then translated into digit morphological asymmetry by promoting the late expression of Hoxd genes
identify the multiple molecular pathways downstream of Hoxa11 (show HOXA11 ELISA Kits)/Hoxd11 function in the developing kidney
Mice lacking all Hox11 (show TLX1 ELISA Kits) activity fail to form metanephric kidney structures; when Hoxd11 is ectopically activated in the anterior mesonephros, we observe a partial transformation to a metanephric program of development.
mice mutant for Hoxd11 and Hoxa11 (show HOXA11 ELISA Kits) show absence of radius and ulna, anterior homeotic transformation of vertebra, and severe kidney defects, suggesting Hoxd11 and Hoxa11 (show HOXA11 ELISA Kits) act together to specify limb outgrowth and patterning of proximodistal axis
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in forelimb morphogenesis.
homeobox gene D-11
, homeobox protein Hox-C11
, homeobox protein Hox-D11a
, homeobox D11
, homeobox protein Hox-D11
, Hox-4.6, mouse, homolog of
, homeo box 4F
, homeo box D11
, homeobox protein Hox-4F
, homeobox protein Hox-4.6
, homeobox protein Hox-5.5
, Hox D11
, homeobox protein Hox-4E
, homeodomain-containing protein