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The protein encoded by HIPK1 belongs to the Ser/Thr family of protein kinases and HIPK subfamily. Additionally we are shipping Homeodomain Interacting Protein Kinase 1 Antibodies (55) and Homeodomain Interacting Protein Kinase 1 Proteins (5) and many more products for this protein.
Analysis of these mutants revealed that HIPK1, HIPK2 (show HIPK2 ELISA Kits) and HIPK3 (show HIPK3 ELISA Kits) but not HIPK4 (show HIPK4 ELISA Kits) are capable of autophosphorylating on other tyrosines
PAGE4, a regulator of c-Jun (show JUN ELISA Kits) transactivation, is phosphorylated by homeodomain-interacting protein kinase 1.
HIPK1 drives p53 (show TP53 ELISA Kits) activation to limit colorectal cancer cell growth.
HIPK1 and HIPK2 (show HIPK2 ELISA Kits), are transcriptional corepressors that regulate TGF-beta (show TGFB1 ELISA Kits)-dependent angiogenesis during embryonic development.
HIPK1 expression was identified only in invasive breast cancer cells with three different patterns: cytoplasmic, nuclear, and both cytoplasmic and nuclear.
These findings indicate that the control of HIPK1 stability by Mdm2 (show MDM2 ELISA Kits)-NORE1 (show RASSF5 ELISA Kits) has a major effect on cell behaviour, and epigenetic inactivation of NORE1 (show RASSF5 ELISA Kits) enables adenocarcinoma formation in vivo through HIPK1 stabilization.
TNFalpha (show TNF ELISA Kits)-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha (show TNF ELISA Kits)-induced ASK1 (show MAP3K5 ELISA Kits)-JNK (show MAPK8 ELISA Kits)/p38 (show CRK ELISA Kits) activation
c-Myb (show MYB ELISA Kits) appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data.
Therefore, our data confirm that the beta-Catenin (show CTNNB1 ELISA Kits) signaling plays a dual role in controlling cell proliferation/differentiation in the brain and indicate that Hipk1 is the crucial interactor able to revert the outcome of beta-Catenin (show CTNNB1 ELISA Kits) signaling in cells.
Despite the expanded marginal zone B cell population in the HIPK1(-/-) mice, the T-independent type 2 humoral response was impaired.
HIPK1 and Daxx (show DAXX ELISA Kits) collaborate in regulating transcription.
characterization of cells and gene-targeted mice deficient for the p53 (show TP53 ELISA Kits)-binding kinase homeodomain-interacting protein kinase 1
The present study indicated the overlapping roles for Hipk1 and Hipk2 (show HIPK2 ELISA Kits) in mediating cell proliferation and apoptosis in response to morphogenetic and genotoxic signals during mouse development.
SENP1 (show SENP1 ELISA Kits) mediates TNF (show TNF ELISA Kits)-induced desumoylation and translocation of HIPK1, leading to an enhanced ASK1 (show MAP3K5 ELISA Kits)-dependent apoptosis.
TNFalpha (show TNF ELISA Kits)-induced desumoylation and cytoplasmic translocation of HIPK1 are critical in TNFalpha (show TNF ELISA Kits)-induced ASK1 (show MAP3K5 ELISA Kits)-JNK (show MAPK8 ELISA Kits)/p38 (show MAPK14 ELISA Kits) activation
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms.
homeodomain interacting protein kinase 1
, homeodomain-interacting protein kinase 1-like
, homeodomain-interacting protein kinase 1
, homeodomain interacting protein kinase 1-like protein
, nuclear body associated kinase 2b
, nuclear body-associated kinase 2
, protein kinase Myak