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HOOK1 encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. Additionally we are shipping Hook Homolog 1 (Drosophila) Proteins (5) and many more products for this protein.
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azh mutation is due to a deletion of exons 10 and 11 in the murine Hook1 gene leading to a non-functional protein. Our results indicate that loss of Hook1 function results in ectopic positioning of microtubular structures within the spermatid
Hook1 and Ankyrin G (show ANK3 Antibodies) are co-locolized, Hook1 also localizes to additional regions of the cell devoid of Ankyrin G (show ANK3 Antibodies) where it interacts with other proteins.
Multiple samples of ejaculated spermatozoa from normal fertile C57BL/6 and infertile Hook1/Hook1 (formerly known as azh/azh) mutant males from uteri after mating.
SHP2 (show PTPN11 Antibodies) positively regulates TGFbeta1 (show TGFB1 Antibodies)-induced epithelial-mesenchymal transition modulated by its novel interacting protein Hook1.
Hook1, a microtubule- and cargo-tethering protein, recognized the cytoplasmic tail of CD147 to help sort it and CD98 (show SLC3A2 Antibodies) into Rab22a (show RAB22A Antibodies)-dependent tubules associated with recycling.
novel interactions between the microtubule-binding Hook1 and the large family of Rab (show HRB Antibodies) GTPases also suggest a link between CLN3 (show CLN3 Antibodies) function, microtubule cytoskeleton and endocytic membrane trafficking
These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the homotypic vacuolar protein sorting complex.
This gene encodes a member of the hook family of coiled-coil proteins, which bind to microtubules and organelles through their N- and C-terminal domains, respectively. The encoded protein localizes to discrete punctuate subcellular structures, and interacts with several members of the Rab GTPase family involved in endocytosis. It is thought to link endocytic membrane trafficking to the microtubule cytoskeleton. Several alternatively spliced transcript variants have been identified, but the full-length nature of some of these variants has not been determined.
hook homolog 1 (Drosophila)
, protein Hook homolog 1
, abnormal spermatozoon head shape
, hook homolog 1