Host Cell Factor C1 (VP16-Accessory Protein) Proteins (HCFC1)

HCFC1 is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. Additionally we are shipping HCFC1 Antibodies (40) and HCFC1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HCFC1 3054 P51610
HCFC1 15161 Q61191
Rat HCFC1 HCFC1 363519  
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Top HCFC1 Proteins at antibodies-online.com

Showing 5 out of 28 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_Escherichia coli (E. coli) Human T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$560.00
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HOST_Escherichia coli (E. coli) Mouse T7 tag,His tag   100 μg Log in to see 15 to 18 Days
$592.00
Details

HCFC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
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Mouse (Murine) ,
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More Proteins for Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1) Interaction Partners

Mouse (Murine) Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1) interaction partners

  1. male epiblast-specific loss of Hcfc1 leads to a developmental arrest at E6.5 with a rapid progressive cell-cycle exit and an associated failure of anterior visceral endoderm migration and primitive streak formation.

  2. Beyond its well-known role in adding beta-O-GlcNAc to serine and threonine residues of nuclear and cytoplasmic proteins, OGT (show OGT Proteins) also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)

  3. survival of the heterozygous Hcfc1(epiKO/+) female embryos llustrates the developmental plasticity of the post-implantation mouse embryo - in this instance, permitting survival of females heterozygous for an X-linked embryonic lethal allele

  4. our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development.

  5. These results indicate that HCF-1 represents a novel transcriptional regulator required for maintaining pancreatic b-cell function.

  6. Ronin/Hcf-1 controls a genetic program that contributes to the unimpeded growth of embryonic stem cells.

  7. HCF-1 is an important component of the viral latency-reactivation cycle and it is regulated by association with a component that is distinct from the identified HCF-1 interaction factors

  8. Bap1 (show BAP1 Proteins) helps to control cell proliferation by regulating HCF-1 protein levels and by associating with genes involved in the G(1)-S transition

Human Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1) interaction partners

  1. Data show that Myc (show MYC Proteins) boxes (MbIV) is required for the association of MYC (show MYC Proteins) with the abundant transcriptional coregulator host cell factor-1 (HCF-1).

  2. The M4 motif (ACTAYRNNNCCCR) is a functional regulatory bipartite cis (show CISH Proteins)-element, which engages a THAP11/HCF-1 complex via binding to the ACTAYR module, while the CCCRRNRNRC subsequence part constitutes a binding platform for Ikaros (show IKZF1 Proteins) and NFKB1 (show NFKB1 Proteins)

  3. Beyond its well-known role in adding beta-O-GlcNAc (show OGT Proteins) to serine and threonine residues of nuclear and cytoplasmic proteins, OGT (show OGT Proteins) also acts as a protease in the maturation of the cell cycle regulator, HCF-1, and serves as an integral member of several protein complexes, many of them linked to gene expression. (Review)

  4. findings show that cellular factors OCT2 and HCF1 bind OriP in association with Epstein-Barr virus nuclear antigen 1 to maintain elevated histone H3K4me3 and transcriptional enhancer function

  5. O-GlcNAcylation of the transcription regulators Host Cell Factor-1 (HCF-1) and Ten-Eleven Translocation protein 2 (TET2) could be readily observed. Our study raises questions on the occurrence and abundance of O-GlcNAcylation as a histone modification

  6. These results demonstrate that distinct OGT (show OGT Proteins)-binding sites in HCF-1 promote proteolysis, and provide novel insights into the mechanism of this unusual protease activity.

  7. our work identifies plausible cellular consequences of missense HCFC1 variants and identifies likely and relevant disease mechanisms that converge on embryonic stages of brain development.

  8. We report here two brothers with dysmorphic features and complex malformations resulting from an X-linked inherited cobalamin deficiency due to HCFC1 gene mutation.

  9. THAP11, ZNF143 (show ZNF143 Proteins), and HCF-1 form a mutually dependent complex on chromatin, which is independent of E2F (show E2F1 Proteins) occupancy.

  10. study reports the tetratricopeptide-repeat domain of O-GlcNAc (show OGT Proteins) transferase binds the carboxyl-terminal portion of an HCF-1 proteolytic repeat such that the cleavage region lies in the glycosyltransferase (show GTDC2 Proteins) active site above uridine diphosphate-GlcNAc; protein glycosylation and HCF-1 cleavage occur in the same active site

Zebrafish Host Cell Factor C1 (VP16-Accessory Protein) (HCFC1) interaction partners

  1. HCFC1 plays a role in craniofacial development, which is in part mediated through the regulation of MMACHC (show MMACHC Proteins) expression

HCFC1 Protein Profile

Protein Summary

This gene is a member of the host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear coactivator is proteolytically cleaved at one of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains. The protein is involved in control of the cell cycle and transcriptional regulation during herpes simplex virus infection. Alternatively spliced variants which encode different protein isoforms have been described\; however, not all variants have been fully characterized.

Gene names and symbols associated with HCFC1

  • host cell factor C1 (VP16-accessory protein) (HCFC1)
  • host cell factor C1 (Hcfc1)
  • host cell factor C1a (hcfc1a)
  • host cell factor C1 (AaeL_AAEL008905)
  • host cell factor C1 (CpipJ_CPIJ014908)
  • host cell factor C1 (HCFC1)
  • host cell factor C1 (VP16-accessory protein) (Hcfc1)
  • AW060991 protein
  • CFF protein
  • fc61g09 protein
  • HCF protein
  • HCF-1 protein
  • HCF1 protein
  • HCFC1 protein
  • HFC1 protein
  • im:7159458 protein
  • MRX3 protein
  • RGD1563804 protein
  • VCAF protein
  • wu:fc61g09 protein
  • wu:fj40c12 protein

Protein level used designations for HCFC1

C1 factor , HCF , VP16 accessory protein , host cell factor 1 , VP16-accessory protein , etID52682.11 , host cell factor C1

GENE ID SPECIES
3054 Homo sapiens
15161 Mus musculus
363519 Rattus norvegicus
564853 Danio rerio
5571204 Aedes aegypti
6048549 Culex quinquefasciatus
100137257 Papio anubis
100328750 Oryctolagus cuniculus
492246 Canis lupus familiaris
512908 Bos taurus
101830931 Mesocricetus auratus
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