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HCFC2 encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Additionally we are shipping Host Cell Factor C2 Antibodies (40) and Host Cell Factor C2 Proteins (5) and many more products for this protein.
Molecular modelling of HCII (show SERPIND1 ELISA Kits) 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67.
In this study, we demonstrate a previously unknown role for HCII (show SERPIND1 ELISA Kits) in host defense.
HCII (show SERPIND1 ELISA Kits) potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK (show PRKAA1 ELISA Kits)-eNOS (show NOS3 ELISA Kits) signaling pathway.
Plasma heparin cofactor II (show SERPIND1 ELISA Kits) activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction.
[REVIEW]HCII (show SERPIND1 ELISA Kits) protects against vascular remodeling, including atherosclerosis
potential for oversulfated disaccharides in controlling HCII (show SERPIND1 ELISA Kits)-regulated thrombin (show F2 ELISA Kits) generation
Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II (show SERPIND1 ELISA Kits) promote
role of basic amino acids of the A helix of heparin cofactor II (show SERPIND1 ELISA Kits) in heparin- or dermatan sulfate-mediated thrombin (show F2 ELISA Kits) inhibition.
Altering heparin cofactor II (show SERPIND1 ELISA Kits) at VAL439 (P6) either impairs inhibition of thrombin (show F2 ELISA Kits) or confers elastase resistance.
The interactions of HCII (show SERPIND1 ELISA Kits) with various heparins in solution competition experiments using SPR (show SPR ELISA Kits) show that while calcium enhances this interaction, the activity of heparin-HCII (show SERPIND1 ELISA Kits) complex against thrombin (show F2 ELISA Kits) is not calcium dependent but can be enhanced by it.
The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.
, host cell factor 2
, heparin cofactor 2
, leuserpin 2
, protease inhibitor leuserpin-2
, serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
, serpin D1