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The product encoded by HCFC2 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. Additionally we are shipping Host Cell Factor C2 Antibodies (40) and many more products for this protein.
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Molecular modelling of HCII (show SERPIND1 Proteins) 1-75 predicted those portions of the acidic extension that had been previously visualized in crystal structures, and suggested that an alpha-helix found between residues 26 and 36 stabilizes one found between residues 61-67.
In this study, we demonstrate a previously unknown role for HCII (show SERPIND1 Proteins) in host defense.
HCII (show SERPIND1 Proteins) potentiates the activation of vascular endothelial cells and the promotion of angiogenesis in response to hindlimb ischemia via an AMPK (show PRKAA1 Proteins)-eNOS (show NOS3 Proteins) signaling pathway.
Plasma heparin cofactor II (show SERPIND1 Proteins) activity was independently and inversely associated with the development of cardiac remodeling, including cardiac concentric change, left atrial enlargement and left ventricular diastolic dysfunction.
[REVIEW]HCII (show SERPIND1 Proteins) protects against vascular remodeling, including atherosclerosis
potential for oversulfated disaccharides in controlling HCII (show SERPIND1 Proteins)-regulated thrombin (show F2 Proteins) generation
Aspartic acid residues 72 and 75 and tyrosine-sulfate 73 of heparin cofactor II (show SERPIND1 Proteins) promote
role of basic amino acids of the A helix of heparin cofactor II (show SERPIND1 Proteins) in heparin- or dermatan sulfate-mediated thrombin (show F2 Proteins) inhibition.
Altering heparin cofactor II (show SERPIND1 Proteins) at VAL439 (P6) either impairs inhibition of thrombin (show F2 Proteins) or confers elastase resistance.
The interactions of HCII (show SERPIND1 Proteins) with various heparins in solution competition experiments using SPR (show SPR Proteins) show that while calcium enhances this interaction, the activity of heparin-HCII (show SERPIND1 Proteins) complex against thrombin (show F2 Proteins) is not calcium dependent but can be enhanced by it.
The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency.
, host cell factor 2
, heparin cofactor 2
, leuserpin 2
, protease inhibitor leuserpin-2
, serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1
, serpin D1