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Hyaluronan Synthase 1 Proteins (HAS1)

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. Additionally we are shipping HAS1 Antibodies (51) and HAS1 Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HAS1 282821  
HAS1 3036 Q92839
HAS1 15116 Q61647
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Top HAS1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 50 μg Log in to see 9 to 11 Days
$495.00
Details
HOST_Escherichia coli (E. coli) Rat His tag 100 μg Log in to see 11 to 13 Days
$792.00
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$967.75
Details

HAS1 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Human ,
, ,
Mouse (Murine) ,
,

More Proteins for Hyaluronan Synthase 1 (HAS1) Interaction Partners

Human Hyaluronan Synthase 1 (HAS1) interaction partners

  1. Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.

  2. The minor allele genotypes of HAS1 SNPs are significantly more frequent in MM, WM, CLL and in affected members of a monoclonal gammopathy-prone family than they are in breast cancer, sporadic MGUS or healthy donors

  3. transcriptional regulation of the HAS and HAS2 (show HAS2 Proteins)-antisense RNA 1 genes, was analyzed.

  4. HAS1 is the main enzyme responsible for hyaluronan production by normal keratinocytes.

  5. The HAS1-dependent coat is induced by inflammatory agents and glycemic stress, mediated by altered presentation of either CD44 (show CD44 Proteins) or hyaluronan, and can offer a rapid cellular response to injury and inflammation.

  6. Among the genes affected by FAK (show PTK2 Proteins) or HAS3 (show HAS3 Proteins) inhibition were genes, playing role in apoptosis, cell cycle regulation, adhesion, transcription, heatshock and WNT (show WNT2 Proteins) pathways.

  7. Inverse expression of hyaluronidase 2 (show HYAL2 Proteins) and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.

  8. aberrant intronic HAS1 splicing in multiple myeloma patients may rely on intronic HAS1 deletions and mutations that are frequent in MM patients but absent from healthy donors

  9. TGF-beta1 (show TGFB1 Proteins) up-regulation of HAS1 transcription was mediated via Smad3 (show SMAD3 Proteins) but not Smad2 (show SMAD2 Proteins), while HAS1 induction by IL-1beta (show IL1B Proteins) was Sp3, not Sp1 (show PSG1 Proteins), dependent.

  10. Hyaluronan synthase 1 (HAS1) requires higher cellular UDP-GlcNAc (show B3GNT3 Proteins) concentration than HAS2 (show HAS2 Proteins) and HAS3 (show HAS3 Proteins)

Pig (Porcine) Hyaluronan Synthase 1 (HAS1) interaction partners

  1. The HA concentration in follicular fluids increased during atresia and HAS1 may be the dominant HAS protein in theca cells to produce HA in pig ovaries.

Mouse (Murine) Hyaluronan Synthase 1 (HAS1) interaction partners

  1. HAS1 was significantly upregulated at the level of gene expression during muscle hypertrophy.

  2. analysis of changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth: Has1 is expressed in preterm birth, while Has2 (show HAS2 Proteins) is induced at term

  3. Selective loss of Has1 and Has3 (show HAS3 Proteins) leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.

  4. repression of HA-accumulation by both COX-2 selective and non-selective COX (show CPOX Proteins) inhibition implicates COX-2 in the regulation of HA synthesis via stimulation of HAS1 and HAS2 (show HAS2 Proteins) expression in vivo

  5. Has-1 transduced ASMCs accumulated the greatest amount of HA containing ECM (show MMRN1 Proteins) than the other transduced ASMCs.Confocal microscopy showed CD44 (show CD44 Proteins) positive monocytes bound to hyaluronidase (show HAase Proteins) sensitive ECM (show MMRN1 Proteins) in has-1 transduced ASMCs.

HAS1 Protein Profile

Protein Summary

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

Gene names and symbols associated with Hyaluronan Synthase 1 Proteins (HAS1)

  • hyaluronan synthase 1 (has1)
  • hyaluronan synthase 1 (HAS1)
  • hyaluronan synthase 1 (Has1)
  • hyaluronan synthase1 (Has1)
  • dg42 protein
  • HAS protein
  • shas1 protein
  • Xhas1 protein

Protein level used designations for Hyaluronan Synthase 1 Proteins (HAS1)

hyaluronan synthase 1 , HA synthase 1 , Hyaluronate synthase 1 , Hyaluronic acid synthase 1 , huHAS1 , hyaluronate synthase 1 , hyaluronic acid synthase 1 , xHAS1

GENE ID SPECIES
403130 Danio rerio
719773 Macaca mulatta
100028664 Monodelphis domestica
100126662 Papio anubis
100145746 Xenopus (Silurana) tropicalis
100598248 Nomascus leucogenys
282821 Rattus norvegicus
3036 Homo sapiens
611700 Canis lupus familiaris
100191062 Sus scrofa
282820 Bos taurus
379383 Xenopus laevis
15116 Mus musculus
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