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Hyaluronan Synthase 2 Proteins (HAS2)

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. Additionally we are shipping Hyaluronan Synthase 2 Antibodies (38) and Hyaluronan Synthase 2 Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HAS2 15117 P70312
Rat HAS2 HAS2 25694 O35776
HAS2 3037 Q92819
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Top Hyaluronan Synthase 2 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

HAS2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
,
Human , ,
, ,

More Proteins for Hyaluronan Synthase 2 (HAS2) Interaction Partners

Zebrafish Hyaluronan Synthase 2 (HAS2) interaction partners

  1. identify Npnt (show NPNT Proteins) as a novel upstream regulator of Bmp4 (show BMP4 Proteins)-Has2 signaling that plays a crucial role in AV canal differentiation

  2. MiR-23 is both necessary and sufficient for restricting the number of endocardial cells that differentiate into endocardial cushion cells by inhibiting Has2 and extracellular hyaluronic acid production.

  3. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5 (show TBX5 Proteins), tbx20 (show TBX20 Proteins), and has2 in the hear

Mouse (Murine) Hyaluronan Synthase 2 (HAS2) interaction partners

  1. the ineffective repair of injured cartilage in Has1 (show HAS1 Proteins)(-/-) joints can be at least partly explained by the markedly enhanced expression of particular genes in pathways linked to ECM (show MMRN1 Proteins) turnover, IL-17 (show IL17A Proteins)/IL-6 (show IL6 Proteins) cytokine signaling, and apoptosis.

  2. these results highlight the role of nSMase2 (show SMPD3 Proteins) in apoptosis evoked by nutrient starvation that could contribute to the delayed apoptosis of hypertrophic chondrocytes in the growth plate, and emphasize the antiapoptotic properties of HAS2

  3. mir (show MLXIP Proteins)-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.

  4. Has2 expression and hyaluronan produced at the tips of epithelial cells play a critical role in driving tubulogenesis and branching in vitro.

  5. Hyaluronan synthase 2 has a role in protecting skin fibroblasts against apoptosis induced by environmental stress

  6. Stimulation with LPS (show TLR4 Proteins) caused rapid increases in versican (show Vcan Proteins) mRNA and protein, a rapid increase in Has1 (show HAS1 Proteins) mRNA, and concomitant inhibition of hyaluronidases 1 and 2, the major hyaluronan degrading enzymes

  7. This study demonistrated that Has2 expression in adult mouse subventricular zone and rostral migratory stream and in ischemic cortex.

  8. This study identifies Has2 as a novel downstream target of Shh (show SHH Proteins) signaling required for joint patterning and chondrogenesis.

  9. HAS2 was significantly upregulated at the level of gene expression during muscle hypertrophy.

  10. analysis of changes in cervical glycosaminoglycan composition during normal pregnancy and preterm birth: Has1 (show HAS1 Proteins) is expressed in preterm birth, while Has2 is induced at term

Human Hyaluronan Synthase 2 (HAS2) interaction partners

  1. HAS2-HA system influences the biological characteristics of human breast cancer cells

  2. Regulation of Hyaluronan (HA) Metabolism Mediated by HYBID (Hyaluronan-binding Protein Involved in HA Depolymerization, KIAA1199) and HA Synthases in Growth Factor-stimulated Fibroblasts.

  3. Our study identified HAS2 as a novel candidate gene for susceptibility to adult asthma.

  4. In contrast to other carcinoma subtypes, HAS2 expression was observed in up to 72.7% of metaplastic carcinomas of breast, a carcinoma subtype related to the epithelial-mesenchymal transition.

  5. transcriptional regulation of the HAS and HAS2-antisense RNA 1 genes, was analyzed.

  6. review of the roles of HAS2 and CD44 (show CD44 Proteins) in breast tumorigenesis [review]

  7. mir (show MLXIP Proteins)-23a-3p causes cellular senescence by targeting hyaluronan synthase 2: possible implication for skin aging.

  8. HAS2 may be involved in the etiology of non-syndromic VSD and have the vital function in the development of heart septum

  9. Stimulation with LPS (show IRF6 Proteins) caused rapid increases in versican (show Vcan Proteins) mRNA and protein, a rapid increase in Has1 (show HAS1 Proteins) mRNA, and concomitant inhibition of hyaluronidases 1 and 2, the major hyaluronan degrading enzymes

  10. UDP-glucose (show UGCG Proteins) activates P2Y14 receptor (show P2RY14 Proteins) and JAK2 (show JAK2 Proteins), increases STAT3 (show STAT3 Proteins) Tyr705 phosphorylation, and enhances transcription of HAS2.

Xenopus laevis Hyaluronan Synthase 2 (HAS2) interaction partners

  1. In the absence of XHas2, early myoblasts underwent apoptosis, failing to complete their muscle differentiation programme. XHas2 activity is also required for migration of hypaxial muscle cells and trunk neural crest cells (NCC (show SLC12A3 Proteins)).

Hyaluronan Synthase 2 (HAS2) Protein Profile

Protein Summary

Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1.

Gene names and symbols associated with Hyaluronan Synthase 2 Proteins (HAS2)

  • hyaluronan synthase 2 (has2)
  • hyaluronan synthase 2 (HAS2)
  • hyaluronan synthase 2 (LOC100228837)
  • hyaluronan synthase 2 (Has2)
  • hyaluronan synthase 2 (SHAS2)
  • DG42 protein
  • Has2 protein
  • XHas2 protein

Protein level used designations for Hyaluronan Synthase 2 Proteins (HAS2)

hyaluronan synthase 2 , hyaluronic acid synthase 2 , HA synthase 2 , hyaluronan synthase homolog , hyaluronate synthase 2 , CHAS2 , xHAS2

GENE ID SPECIES
260350 Danio rerio
472850 Pan troglodytes
482032 Canis lupus familiaris
100008626 Oryctolagus cuniculus
100009708 Equus caballus
100145711 Xenopus (Silurana) tropicalis
100228837 Taeniopygia guttata
15117 Mus musculus
25694 Rattus norvegicus
3037 Homo sapiens
281220 Bos taurus
395594 Gallus gallus
397120 Sus scrofa
399146 Xenopus laevis
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