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Hyaluronan Synthase 3 Proteins (HAS3)

The protein encoded by HAS3 is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. Additionally we are shipping Hyaluronan Synthase 3 Antibodies (56) and Hyaluronan Synthase 3 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HAS3 3038 O00219
HAS3 15118 O08650
Rat HAS3 HAS3 266805  
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Top Hyaluronan Synthase 3 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

HAS3 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Hyaluronan Synthase 3 (HAS3) Interaction Partners

Human Hyaluronan Synthase 3 (HAS3) interaction partners

  1. Overexpression of HAS3 decreased ERK1/2 phosphorylation suggesting that inhibition of MAP-kinase (show MAPK1 Proteins) signaling was responsible for decreased melanoma cell adhesion, migration and proliferation.

  2. HAS3 underexpression is associated with advanced tumor stage and adverse pathological features, as well as implies inferior clinical outcomes for both groups of patients with UTUCs and UBUCs, suggesting its critical role in tumor progression

  3. Hyaluronan accumulation by HAS3 favors pancreatic cancer growth.

  4. Transcriptional factor binding analysis indicated that HAS3 gene promoter lacks of canonical TATA box, but contains classical GC box as well as other putative binding sites for transcriptional factors

  5. HAS3 mRNA expression level increases in atopic dermatitis lesions compared with healthy and non-lesional skin

  6. Rab10 (show RAB10 Proteins) silencing increased the plasma membrane residence of HAS3, resulting in a significant increase of hyaluronan secretion and an enlarged cell surface HA coat, whereas Rab10 (show RAB10 Proteins) overexpression suppressed hyaluronan synthesis.

  7. Hyaluronan (HA) produced by HAS3 is a ubiquitous component of the extracellular matrix and plays an active role in tissue remodeling. In addition, HA is known to reduce reactive oxygen species (ROS (show ROS1 Proteins)) -induced cardiac injury.

  8. Data indicate that oxLDL doubled the transcripts of hyaluronan synthases HAS2 (show HAS2 Proteins) and HAS3 and hyaluronan deposition via the scavenger receptor LOX-1 (show OLR1 Proteins).

  9. Inverse expression of hyaluronidase 2 (show HYAL2 Proteins) and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.

  10. Hyaluronan synthase 1 (HAS1 (show HAS1 Proteins)) requires higher cellular UDP-GlcNAc (show B3GNT3 Proteins) concentration than HAS2 (show HAS2 Proteins) and HAS3

Mouse (Murine) Hyaluronan Synthase 3 (HAS3) interaction partners

  1. HAS3-mediated HA synthesis after vessel injury supports seminal signaling pathways in activation of VSMC, increases platelet-derived growth factor BB-mediated migration, and in turn enhances neointimal hyperplasia in vivo.

  2. This study demonstrates that the ablation of Has3-dependent HA causes reduced ECS volume in the CA1 (show CA1 Proteins) stratum pyramidale, epileptiform activity in the CA1 (show CA1 Proteins) region, and epileptic seizures in the mutant mouse.

  3. Selective loss of Has1 (show HAS1 Proteins) and Has3 leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.

Xenopus laevis Hyaluronan Synthase 3 (HAS3) interaction partners

  1. sequence of xlHAS3(hyaluronan synthase 3) mRNA, its genomic organization and expression in adult tissues as well as during embryonic development; in situ hybridization indicates that expression is restricted to the developing inner ear and cement gland

Pig (Porcine) Hyaluronan Synthase 3 (HAS3) interaction partners

  1. hyaluronan synthase 3 is expressed by the porcine endosalpinx epithelium and the levels of expression do not vary during the critical periods of sperm transport and fertilization

Hyaluronan Synthase 3 (HAS3) Protein Profile

Protein Summary

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with Hyaluronan Synthase 3 Proteins (HAS3)

  • hyaluronan synthase 3 (HAS3)
  • hyaluronan synthase 3 (has3)
  • hyaluronan synthase 3 (Has3)
  • CHAS3 protein
  • dg42III protein
  • HAS3 protein
  • xhas3 protein
  • xx:af190743gs1 protein
  • xx:af190743gs2 protein

Protein level used designations for Hyaluronan Synthase 3 Proteins (HAS3)

hyaluronan synthase 3 , hyaluronan synthase 3-like , HA synthase 3 , hyaluronate synthase 3 , hyaluronic acid synthase 3 , af190743gs2

GENE ID SPECIES
100066947 Equus caballus
454195 Pan troglodytes
704121 Macaca mulatta
100126755 Papio anubis
100400259 Callithrix jacchus
100462167 Pongo abelii
100475331 Ailuropoda melanoleuca
100542703 Meleagris gallopavo
100558635 Anolis carolinensis
3038 Homo sapiens
15118 Mus musculus
266805 Rattus norvegicus
282555 Danio rerio
399037 Xenopus laevis
427564 Gallus gallus
489739 Canis lupus familiaris
408053 Sus scrofa
286824 Bos taurus
100009454 Oryctolagus cuniculus
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