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Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.. Additionally we are shipping HAPLN1 Proteins (10) and HAPLN1 Kits (6) and many more products for this protein.
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Human Polyclonal HAPLN1 Primary Antibody for FACS, IHC (p) - ABIN653748
Wheeler, Metter, Tanaka, Absher, Higgins, Zahn, Wilhelmy, Davis, Singleton, Myers, Ferrucci, Kim: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging. in PLoS genetics 2009
Show all 3 references for ABIN653748
Human Polyclonal HAPLN1 Primary Antibody for FACS, IHC (p) - ABIN954321
Cénit, Blanco-Kelly, de las Heras, Bartolomé, de la Concha, Urcelay, Arroyo, Martínez: Glypican 5 is an interferon-beta response gene: a replication study. in Multiple sclerosis (Houndmills, Basingstoke, England) 2009
Show all 2 references for ABIN954321
Human Polyclonal HAPLN1 Primary Antibody for WB - ABIN2777097
Seyfried, McVey, Almond, Mahoney, Dudhia, Day et al.: Expression and purification of functionally active hyaluronan-binding domains from human cartilage link protein, aggrecan and versican: formation of ternary complexes with defined hyaluronan ... in The Journal of biological chemistry 2005
Hapln1a-ECM (show MMRN1 Antibodies) stabilizes the secreted growth factor (show WNT2 Antibodies) Semaphorin3d (Sema3d (show SEMA3D Antibodies)), which has been independently shown to mediate Cx43 (show GJA1 Antibodies) dependent phenotypes during regeneration.
Hapln1a has a critical role in connexin43 (show GJA1 Antibodies)-dependent growth and patterning in the regenerating fin skeleton
The cloning and characterization of crtl1 and its expression during embryogenesis are reported.
stimulates proteoglycan (show Vcan Antibodies) and types II and IX collagens in intervertebral disc cells - stimulates synthesis of matrix molecules
CSGalNAcT-1 (show CSGALNACT1 Antibodies) and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis.
HAPLN1 is overexpressed in metastatic melanoma and is secreted exclusively by the tumor cells
Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women.
An in vitro model of perineuronal nets has been developed demonstrating that cartilage link protein (along with hyaluronan synthase) are necessary for their formation.
link protein may function as a stabilizer of the interaction between aggrecan (show ACAN Antibodies) and hyaluronan in cartilage and between versican (show Vcan Antibodies) and hyaluronan in many tissues
SOX9 (show SOX9 Antibodies) is a key regulator of CRTL1
cLP (show CALML3 Antibodies) and versican (show Vcan Antibodies) did not bind directly to each other in solution yet formed ternary complexes with hyaluronan
Overexpression of HAPLN1 and its SP-IgV domain increases tumorigenic properties of mesothelioma. Thus, targeting the SP-IgV domain may be one of the therapeutic approaches in cancer treatment.
Aggrecan (show ACAN Antibodies), link protein and TN-R (show TNR Antibodies) were identified to be essential for the neuroprotective properties of the perineuronal net.
Mef2c (show MEF2C Antibodies) regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart.
our findings demonstrate that the formation of perineuronal nets triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS
there is a general and systemic function of link protein in the organization of extracellular matrix in a number of tissues, possibly interacting with other proteoglycans, such as versican (show Vcan Antibodies), brevican (show BCAN Antibodies), and neurocan (show NCAN Antibodies)
Data suggest that the reported temporal co-expression of cartilage link protein and neurocan (show NCAN Antibodies) in developing brain implicates the possibility of a cooperative function of these molecules.
reduced versican (show Vcan Antibodies) expression may contribute to a subset of the cardiac abnormalities observed in the Crtl1(-/-) mouse.
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
hyaluronan and proteoglycan link protein 1
, cartilage linking protein 1
, hyaluronan proteoglycan link protein 1
, cartilage link protein
, cartilage-link protein
, cartilage-linking protein 1
, proteoglycan link protein
, Cartilage link protein
, cartilage link protein 1
, link protein
, link protein precursor (AA -15 to 339)