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Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.. Additionally we are shipping HAPLN1 Antibodies (52) and HAPLN1 Kits (1) and many more products for this protein.
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Human HAPLN1 Protein expressed in Wheat germ - ABIN1306351
Mathur, Blais, Goparaju, Neubert, Pass, Levon: Development of a biosensor for detection of pleural mesothelioma cancer biomarker using surface imprinting. in PLoS ONE 2013
Hapln1a-ECM (show MMRN1 Proteins) stabilizes the secreted growth factor (show WNT2 Proteins) Semaphorin3d (Sema3d (show SEMA3D Proteins)), which has been independently shown to mediate Cx43 (show GJA1 Proteins) dependent phenotypes during regeneration.
Hapln1a has a critical role in connexin43 (show GJA1 Proteins)-dependent growth and patterning in the regenerating fin skeleton
The cloning and characterization of crtl1 and its expression during embryogenesis are reported.
stimulates proteoglycan (show Vcan Proteins) and types II and IX collagens in intervertebral disc cells - stimulates synthesis of matrix molecules
CSGalNAcT-1 (show CSGALNACT1 Proteins) and Hapln-1 may play important roles in the pathogenesis of Kashin-Beck disease and osteoarthritis.
HAPLN1 is overexpressed in metastatic melanoma and is secreted exclusively by the tumor cells
Single-nucleotide polymorphism in the hyaluronan and proteoglycan link protein 1 (HAPLN1) gene is associated with spinal osteophyte formation and disc degeneration in Japanese women.
An in vitro model of perineuronal nets has been developed demonstrating that cartilage link protein (along with hyaluronan synthase) are necessary for their formation.
link protein may function as a stabilizer of the interaction between aggrecan (show ACAN Proteins) and hyaluronan in cartilage and between versican (show Vcan Proteins) and hyaluronan in many tissues
SOX9 (show SOX9 Proteins) is a key regulator of CRTL1
cLP (show CALML3 Proteins) and versican (show Vcan Proteins) did not bind directly to each other in solution yet formed ternary complexes with hyaluronan
Overexpression of HAPLN1 and its SP-IgV domain increases tumorigenic properties of mesothelioma. Thus, targeting the SP-IgV domain may be one of the therapeutic approaches in cancer treatment.
Aggrecan (show ACAN Proteins), link protein and TN-R (show TNR Proteins) were identified to be essential for the neuroprotective properties of the perineuronal net.
Mef2c (show MEF2C Proteins) regulates transcription of the extracellular matrix protein cartilage link protein 1 in the developing murine heart.
our findings demonstrate that the formation of perineuronal nets triggered by neuronal Crtl1 synthesis is a key event in the diminuation of plasticity in the adult CNS
there is a general and systemic function of link protein in the organization of extracellular matrix in a number of tissues, possibly interacting with other proteoglycans, such as versican (show Vcan Proteins), brevican (show BCAN Proteins), and neurocan (show NCAN Proteins)
Data suggest that the reported temporal co-expression of cartilage link protein and neurocan (show NCAN Proteins) in developing brain implicates the possibility of a cooperative function of these molecules.
reduced versican (show Vcan Proteins) expression may contribute to a subset of the cardiac abnormalities observed in the Crtl1(-/-) mouse.
Stabilizes the aggregates of proteoglycan monomers with hyaluronic acid in the extracellular cartilage matrix.
hyaluronan and proteoglycan link protein 1
, cartilage linking protein 1
, hyaluronan proteoglycan link protein 1
, cartilage link protein
, cartilage-link protein
, cartilage-linking protein 1
, proteoglycan link protein
, Cartilage link protein
, cartilage link protein 1
, link protein
, link protein precursor (AA -15 to 339)