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HYAL2 encodes a weak acid-active hyaluronidase. Additionally we are shipping HYAL2 Kits (8) and HYAL2 Proteins (8) and many more products for this protein.
Showing 10 out of 93 products:
Human Polyclonal HYAL2 Primary Antibody for EIA, FACS - ABIN952809
Monzon, Fregien, Schmid, Falcon, Campos, Casalino-Matsuda, Forteza: Reactive oxygen species and hyaluronidase 2 regulate airway epithelial hyaluronan fragmentation. in The Journal of biological chemistry 2010
Show all 3 references for ABIN952809
Human Polyclonal HYAL2 Primary Antibody for EIA, IHC (p) - ABIN952808
de la Motte, Nigro, Vasanji, Rho, Kessler, Bandyopadhyay, Danese, Fiocchi, Stern: Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines. in The American journal of pathology 2009
Show all 3 references for ABIN952808
Human Polyclonal HYAL2 Primary Antibody for ELISA, WB - ABIN1327669
Monzón, Manzanares, Schmid, Casalino-Matsuda, Forteza: Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells. in American journal of respiratory cell and molecular biology 2008
Show all 2 references for ABIN1327669
Data show that DNA methylation (show HELLS Antibodies) at CpG island of hyaluronoglucosaminidase 2 (HYLA2) could be used to identify stage II and III colon cancer patients who are most likely to benefit from 5-flourouracil chemotherapy with respect to progression-free survival.
CD44 (show CD44 Antibodies) knock-down in bovine and human chondrocytes results in release of bound HYAL2.
High expression of S100P (show S100P Antibodies) and HYAL2 is significantly associated with advanced disease and shorter survival of triple-negative breast cancer and S100P (show S100P Antibodies) and HYAL2 could be potential prognostic markers of TNBC.
HYAL2 plays a redundant role in the catalysis of megadalton HA to its 20 kDa intermediate during fertilization.
Lower platelet HYAL2 levels and activity are associated with inflammatory bowel disease.
A strong association between decreased HYAL2 methylation in peripheral blood and BC.
Inverse expression of hyaluronidase 2 and hyaluronan synthases 1-3 is associated with reduced hyaluronan content in malignant cutaneous melanoma.
HAS2 (show HAS2 Antibodies)-HYAL2/CD44 (show CD44 Antibodies) system may support spontaneous chemokinesis of human cancer cells through self-degradation of HMW-HA to produce LMW-HA by an autocrine mechanism.
Hyaluronan synthases (HAS1 (show HAS1 Antibodies)-3) and hyaluronidases (HYAL1 (show HYAL1 Antibodies)-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
Overexpression of HYAL2 is associated with colorectal cancer.
hyaluronidase 2 deficiency induces chronic thrombotic microangiopathy with hemolytic anemia in mice.
HYAL1 (show HYAL1 Antibodies) is necessary for the breakdown of intracellular HA in the cortex, whereas HYAL2 is essential for the degradation of extracellular HA in all kidney regions
Murine hyaluronidase 2 deficiency results in extracellular hyaluronan accumulation and severe cardiopulmonary dysfunction
Hyal-2 enhancement of tumor necrosis factor-alpha (show TNF Antibodies)-stimulated cytotoxicity in fibroblasts is blocked by Transforming growth factor-beta1.
Hyaluronidase (show HAase Antibodies) induces ovarian granulosa cell apoptosis and is involved in follicular atresia.
murine HYAL2 has a physiological activity in vivo that is relevant for craniovertebral bone formation, maintenance of plasma hyaluronan concentrations, and erythrocyte and platelet homeostasis.
platelets and megakaryocytes contain only hyaluronidase 2 (HYAL2) but not HYAL1 (show HYAL1 Antibodies)
HYAL2 expression improves the blastocyst rate and embryo quality, an effect which requires CD44 (show CD44 Antibodies) activity and MAPK (show MAPK1 Antibodies) signaling.
May degrade hyaluronan by analogy to human HYAL2, which is a weak acid-active hyaluronidase (show HAase Antibodies). Serves as an entry receptor for jaagsiekte sheep retrovirus in sheep and bovine as well as for enzootic nasal tumor virus in sheep.
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
hyaluronidase 2 b
, hyaluronoglucosaminidase 2
, hyaluronidase 2
, hyaluronidase 2 a
, PH-20 homolog
, PH20 homolog
, lung carcinoma protein 2
, lysosomal hyaluronidase
, GPI-anchored surface protein
, JSRV envelope protein receptor