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Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 1 Proteins (HSD3B1)

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. Additionally we are shipping HSD3B1 Antibodies (99) and HSD3B1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSD3B1 3283 P14060
HSD3B1 15492 P24815
Rat HSD3B1 HSD3B1 360348 P22071
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Top HSD3B1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HSD3B1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 1 (HSD3B1) Interaction Partners

Human Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 1 (HSD3B1) interaction partners

  1. HSD3B1 is involved in aldosterone production, despite its lower levels of expression compared with HSD3B2 (show HSD3B2 Proteins), and also possibly associated with KCNJ5 (show KCNJ5 Proteins) mutation in aldosterone-producing adenoma.

  2. Expression of the genes HSD3B1, HSD17B3 (show HSD17B3 Proteins), and SRD5A2 (show SRD5A2 Proteins) was significantly increased in BPH (show GLI3 Proteins) tissues compared to normal adjacent prostate tissues.

  3. prostate cancer patients who harbored the heterozygous variant HSD3B1 (1245C) are more likely to develop to castration-resistant prostate cancer but do not have shorter time to biochemical recurrence, shorter survival time or higher mortality risk

  4. No evidence to support that HSD3B1 is involved in aldosterone synthesis in the human adrenal cortex or that genetic variation in HSD3B1 affects blood pressure or hypertension.

  5. Results indicate that orexin-A significantly enhanced the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD (show CHST3 Proteins)) and the production of cortisol, and increased the phosphorylation of AKT (show AKT1 Proteins) protein in the NCI-H295R adrenocortical cells.

  6. The AngII-NGFIB/NURR1 (show NR4A2 Proteins) pathway controls HSD3B1 expression.

  7. The AAT haplotype of the HSD3B1 gene was significantly associated with increased risks of acne vulgaris in Han Chinese from the Southwest China.

  8. HSD3B1 T-->C Leu338, HTR2A T102C, GNAS (show GNAS Proteins) T393C, and RGS2 (show RGS2 Proteins) G638A polymorphisms were not associated with hypertension risk.

  9. Risk-conferring genetic variations in the HSD3beta gene influenced susceptibility of primary aldosteronism. Concomitant presence of rs6203 CC and rs12410453 GA genotypes synergistically increased aldosterone-to-renin (show REN Proteins) ratio

  10. HSD3B1 is a highly specific trophoblast-associated marker that can be used in the distinction of trophoblastic tumorlike lesions and tumors from nontrophoblastic lesions and tumors.

Pig (Porcine) Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 1 (HSD3B1) interaction partners

  1. The effects of androgen blockade on the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD (show HAL Proteins)), CYP17 (show CYP17A1 Proteins), and 17beta-hydroxysteroid dehydrogenase (show HSD17B7 Proteins) type 1 (17beta-HSD1 (show SPAG8 Proteins)) in the porcine fetus are reported.

  2. Study found that uncastrated Duroc pigs with the GG SNP5 genotype had significantly higher 3beta-HSD (show HAL Proteins) mRNA levels than did uncastrated Duroc pigs with other SNP5 genotypes.

  3. Significant sequence variations were found in the 5'flanking region of the 3beta-HSD (show HAL Proteins) gene, where differences in the number of TTAT repeats and 3 SNP were observed in the different breeds

  4. The expression of 3betaHSD mRNA was detected by the use of RT-PCR technique in all investigated samples isolated at different stages of pregnancy.

  5. Genistein and daidzein have direct effects on porcine granulosa cell progesterone synthesis involving the inhibition of 3-beta-HSD enzyme activity.

Cow (Bovine) Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 1 (HSD3B1) interaction partners

  1. Granulosa and theca of well-characterized large bovine follicles were isolated before and after the LH surge. CYP19A1 (show CYP19A1 Proteins), HSD3B1, and CYP17A1 (show CYP17A1 Proteins) transcripts were quantified by real-time PCR (qPCR) and the chromatin condensation was determined.

  2. Serum free culture conditions significantly enhanced Cyp17 (show CYP17A1 Proteins) and Csh1 (show PRL3D1 Proteins) but not Hsd3b expression in trophoblast.

Mouse (Murine) Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 1 (HSD3B1) interaction partners

  1. LH induction of 3beta-HSD (show HAL Proteins) in nonpregnant mouse endometrium.

  2. HIF-1alpha (show HIF1A Proteins) is constitutively present in the Leydig cells of the murine testis, where it potentially regulates Hsd3b1 transcription, and thus male reproductive function.

HSD3B1 Protein Profile

Protein Summary

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.

Gene names and symbols associated with HSD3B1

  • hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (HSD3B1)
  • hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (hsd3b1)
  • hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 (Hsd3b1)
  • hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2)
  • 3b-HSD protein
  • 3BETAHSD protein
  • D3Ertd383e protein
  • HSD3B protein
  • HSD3B1 protein
  • HSDB3 protein
  • HSDB3A protein
  • I protein
  • MGC131206 protein
  • SDR11E1 protein

Protein level used designations for HSD3B1

3 beta-hydroxysteroid dehydrogenase , 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase , 3-beta-HSD , hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 , 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 , 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1-like , 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I , 3-beta-HSD I , 3-beta-hydroxy-5-ene steroid dehydrogenase , 3-beta-hydroxy-Delta(5)-steroid dehydrogenase , delta-5-3-ketosteroid isomerase , hydroxy-delta-5-steroid dehydrogenase, 3 beta-and steroid delta-isomerase 1 , progesterone reductase , short chain dehydrogenase/reductase family 11E, member 1 , steroid Delta-isomerase , trophoblast antigen FDO161G , 3-beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase , hydroxy-delta-MAY-steroid dehydrogenase, 3 beta- and steroid delta-isomerase , hydroxysteroid dehydrogenase-1, delta<5>-3-beta , 3 beta-hydroxysteroid dehydrogenase 1 , 3-beta-hydroxysteroid dehydrogenase

GENE ID SPECIES
100034078 Equus caballus
469446 Pan troglodytes
734818 Xenopus laevis
751770 Taeniopygia guttata
100451655 Pongo abelii
3283 Homo sapiens
445539 Sus scrofa
281824 Bos taurus
15492 Mus musculus
360348 Rattus norvegicus
713091 Macaca mulatta
483146 Canis lupus familiaris
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