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Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 Proteins (HSD3B2)

The protein encoded by HSD3B2 is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. Additionally we are shipping Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 Antibodies (28) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat HSD3B2 HSD3B2 682974 P22072
HSD3B2 3284 P26439
HSD3B2 15493 P26149
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Top Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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HSD3B2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 (HSD3B2) Interaction Partners

Human Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 (HSD3B2) interaction partners

  1. HSD3B1 (show HSD3B1 Proteins) is involved in aldosterone production, despite its lower levels of expression compared with HSD3B2, and also possibly associated with KCNJ5 (show KCNJ5 Proteins) mutation in aldosterone-producing adenoma.

  2. Patients with HSD3B2 deficiency and 21-hydroxylase deficiency suffer similar morbid complications from under- and overtreatment, but HSD3B2 deficiency is associated with a distinctive pattern of sex steroid dysmetabolism.

  3. both area and ratio of 3betaHSD (show HSD3B1 Proteins) and CYB5A (show CYB5A Proteins) double positive cells, which could represent the hybrid cells of zona fasciculate and zona reticularis, are correlated with adrenal development and could influence age-related serum androstenedione levels.

  4. Results indicate that orexin-A significantly enhanced the expression of 3beta-hydroxysteroid dehydrogenase (3beta-HSD (show CHST3 Proteins)) and the production of cortisol, and increased the phosphorylation of AKT (show AKT1 Proteins) protein in the NCI-H295R adrenocortical cells.

  5. the CYP11A1 (show CYP11A1 Proteins), CYP17A1 (show CYP17A1 Proteins), HSD3B2, SRD5A2 (show SRD5A2 Proteins), and HSD17B6 (show HSD17B6 Proteins) mRNA levels in metastases were significantly lower.

  6. The cause of adrenocortical insufficiency in the studied family appears to be two novel homozygous mutations in the 3beta-HSD (show CHST3 Proteins) gene.

  7. Risk-conferring genetic variations in the HSD3beta gene influenced susceptibility of primary aldosteronism. Concomitant presence of rs6203 CC and rs12410453 GA genotypes synergistically increased aldosterone-to-renin (show REN Proteins) ratio

  8. low ratio of cytochrome P450 family 17/3 beta-hydroxysteroid dehydrogenase type II with high expression of steroid 11-beta-monooxygenase (show CYP11B1 Proteins) seems to explain steroidogenic characteristics of aldosterone-producing adenomas

  9. HSD3B (show HSD3B1 Proteins) SNP and gene-gene interactions in genetic susceptibility to bladder cancer

  10. Interleukin-4 and prostaglandin E2 synergistically up-regulate 3beta-hydroxysteroid dehydrogenase type 2 in endometrioma stromal cells.

Mouse (Murine) Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 (HSD3B2) interaction partners

  1. molecular chaperone (show HSP90AA1 Proteins)-assisted folding of 3-beta hydroxysteroid dehydrogenase-2 is a physiological requirement

Hydroxy-delta-5-Steroid Dehydrogenase, 3 beta- and Steroid delta-Isomerase 2 (HSD3B2) Protein Profile

Protein Summary

The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with HSD3B2

  • 3 beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase type II (Hsd3b)
  • hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2)
  • hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (Hsd3b2)
  • 3b-HSD protein
  • HSD3B protein
  • HSD3B1 protein
  • HSDB protein
  • SDR11E2 protein

Protein level used designations for HSD3B2

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 , 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II , 3-beta-HSD II , 3 beta-HSD type II , 3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II , 3-beta-HSD adrenal and gonadal type , 3-beta-hydroxy-5-ene steroid dehydrogenase , 3-beta-hydroxy-Delta(5)-steroid dehydrogenase , delta 5-delta 4-isomerase type II , progesterone reductase , short chain dehydrogenase/reductase family 11E, member 2 , 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase , 3-beta-HSD , 3-beta-hydroxysteroid dehydrogenase , hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 , 3 beta-hydroxysteroid dehydrogenase 2 , hydroxysteroid dehydrogenase-2, delta<5>-3-beta

GENE ID SPECIES
682974 Rattus norvegicus
3284 Homo sapiens
483146 Canis lupus familiaris
15493 Mus musculus
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