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HAO1 is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Additionally we are shipping Hydroxyacid Oxidase (Glycolate Oxidase) 1 Antibodies (79) and Hydroxyacid Oxidase (Glycolate Oxidase) 1 Kits (4) and many more products for this protein.
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Human HAO1 Protein expressed in Escherichia coli (E. coli) - ABIN2005023
Murray, Holmes, Lowther: Active site and loop 4 movements within human glycolate oxidase: implications for substrate specificity and drug design. in Biochemistry 2008
Show all 5 references for ABIN2005023
Human HAO1 Protein expressed in Escherichia coli (E. coli) - ABIN667522
Pennati, Gadda: Involvement of ionizable groups in catalysis of human liver glycolate oxidase. in The Journal of biological chemistry 2009
Show all 2 references for ABIN667522
The study presents the first spectroscopic evidence of the formation of an intermediate with absorbance features resembling those of a flavosemiquinone in the oxidative half-reaction of glycolate oxidase (show HAO2 Proteins).
These inhibitions suggest that glycolate binds to the active site of the reduced enzyme, and that DCIP (show SAMHD1 Proteins) also has affinity for the oxidized enzyme.
Active site and loop 4 movements within human glycolate oxidase (show HAO2 Proteins).
This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site.
hydroxyacid oxidase 1
, Hydroxyacid oxidase 1
, hydroxyacid oxidase (glycolate oxidase) 1
, (S)-2-hydroxy-acid oxidase
, glycolate oxidase
, hydroxyacid oxidase 1, liver
, glycolate oxidase 1