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Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit Proteins (HADHA)

HADHA encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. Additionally we are shipping Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit Antibodies (50) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HADHA 3030 P40939
Rat HADHA HADHA 170670 Q64428
HADHA 97212 Q8BMS1
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Top Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details

HADHA Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit (HADHA) Interaction Partners

Human Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit (HADHA) interaction partners

  1. Exposure to bezafibrate (400 muM for 48 h) increased the abundance of HADHA and HADHB (show HADHB Proteins) mRNAs.

  2. findings suggest an auxiliary role for HADHA in miRNA biogenesis and help in better understanding of molecular mechanisms underlying RNAi pathway

  3. nonstructural protein 5 (show CAPS Proteins) (NS5 (show RAF1 Proteins)) interacted with hydroxyacyl-CoA dehydrogenase (show HADH Proteins) alpha and beta subunits, two components of the mitochondrial trifunctional protein (MTP (show MT1B Proteins)) involved in LCFA beta-oxidation

  4. Crystal structures of human mitochondrial 3-ketoacyl-CoA thiolase (show HADHB Proteins) (hT1) in the apo (show C9orf3 Proteins) form and in complex with CoA have been determined at 2.0 A resolution. The structures confirm the tetrameric quaternary structure of this degradative thiolase (show HADHB Proteins).

  5. Mitochondrial Trifunctional-Protein depletion during hepatitis c virus infection rendered cells less responsive to alpha interferon (show IFNA Proteins) treatment by impairing IFN-stimulated gene expression.

  6. Report probable Kashubian origin of the prevalent HADHA c.1528G>C mutation responsible for long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency in Poland.

  7. Free fatty acids might affect the expression of mitochondrial beta-oxidation enzyme of LCHAD in trophoblast cells.

  8. these findings lend support to the hypothesis that mutations in the HADHA gene may be directly associated with and potentially causative of Maternal floor infarction/massive perivillous fibrin deposition

  9. TP-alpha, collagen alpha-1(VI) chain (show COL6A1 Proteins) and S100A9 (show S100A9 Proteins) are potential biomarkers of esophageal squamous cell carcinoma, and may play an important role in tumorigenesis and development of ESCC.

  10. High HADHA protein expression is associated with response to platinum-based chemotherapy for lung cancer.

Mouse (Murine) Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit (HADHA) interaction partners

  1. nonstructural protein 5 (show CAPS Proteins) (NS5 (show RAF1 Proteins)) interacted with hydroxyacyl-CoA dehydrogenase (show HADH Proteins) alpha and beta subunits, two components of the mitochondrial trifunctional protein (MTP (show LAPTM4A Proteins)) involved in LCFA beta-oxidation

  2. Heterozygosity for beta-oxidation defects predisposes to fatty live disease and insulin (show INS Proteins) resistance in aging mice

Hydroxyacyl-Coenzyme A Dehydrogenase/3-Ketoacyl-Coenzyme A Thiolase/enoyl-Coenzyme A Hydratase (Trifunctional Protein), alpha Subunit (HADHA) Protein Profile

Protein Summary

This gene encodes the alpha subunit of the mitochondrial trifunctional protein, which catalyzes the last three steps of mitochondrial beta-oxidation of long chain fatty acids. The mitochondrial membrane-bound heterocomplex is composed of four alpha and four beta subunits, with the alpha subunit catalyzing the 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities. Mutations in this gene result in trifunctional protein deficiency or LCHAD deficiency. The genes of the alpha and beta subunits of the mitochondrial trifunctional protein are located adjacent to each other in the human genome in a head-to-head orientation.

Gene names and symbols associated with HADHA

  • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (HADHA)
  • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (hadha)
  • hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase, alpha subunit a (hadhaa)
  • hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit (Hadha)
  • hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit (Hadha)
  • C77020 protein
  • cb1055 protein
  • ECHA protein
  • GBP protein
  • HADH protein
  • hadha protein
  • im:7136067 protein
  • LCEH protein
  • LCHAD protein
  • Mtpa protein
  • RGD1560655 protein
  • TP-ALPHA protein
  • wu:fa14c08 protein

Protein level used designations for HADHA

trifunctional enzyme subunit alpha, mitochondrial , dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit hydroxyacyl-Coenzyme A , hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), alpha subunit , mitochondrial trifunctional protein, alpha subunit , CFR-associated protein p70 , hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A hydratase (trifunctional protein) , hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit , hydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme A hydratase (trifunctional protein) alpha subunit , mitochondrial trifunctional protein, alpha subunit-like , trifunctional enzyme subunit alpha, mitochondrial-like , 3-ketoacyl-Coenzyme A (CoA) thiolase, alpha subunit , 3-oxoacyl-CoA thiolase , 78 kDa gastrin-binding protein , gastrin-binding protein , long-chain 2-enoyl-CoA hydratase , long-chain-3-hydroxyacyl-CoA dehydrogenase , mitochondrial long-chain 2-enoyl-Coenzyme A (CoA) hydratase, alpha subunit , mitochondrial long-chain L-3-hydroxyacyl-Coenzyme A (CoA) dehydrogenase, alpha subunit , mitochondrial trifunctional enzyme, alpha subunit , TP-alpha

GENE ID SPECIES
281810 Bos taurus
394832 Xenopus (Silurana) tropicalis
395929 Gallus gallus
444044 Xenopus laevis
459079 Pan troglodytes
553401 Danio rerio
695975 Macaca mulatta
100071381 Equus caballus
100077524 Ornithorhynchus anatinus
100172963 Pongo abelii
100192316 Ovis aries
100355022 Oryctolagus cuniculus
100369576 Saccoglossus kowalevskii
100390439 Callithrix jacchus
100469654 Ailuropoda melanoleuca
3030 Homo sapiens
475687 Canis lupus familiaris
397012 Sus scrofa
170670 Rattus norvegicus
97212 Mus musculus
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