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Hydroxymethylbilane Synthase Proteins (HMBS)

HMBS encodes a member of the hydroxymethylbilane synthase superfamily. Additionally we are shipping Hydroxymethylbilane Synthase Antibodies (66) and Hydroxymethylbilane Synthase Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HMBS 3145 P08397
HMBS 15288 P22907
HMBS 25709  
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Top Hydroxymethylbilane Synthase Proteins at antibodies-online.com

Showing 8 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,982.83
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,982.83
Details
HOST_Human Human His tag   10 μg Log in to see 5 Days
$203.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$382.86
Details

HMBS Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Hydroxymethylbilane Synthase Proteins

  1. Human HMBS Protein expressed in Escherichia coli (E. coli) - ABIN667690 : Schneider-Yin, Hergersberg, Schuurmans, Gregor, Minder: Mutation hotspots in the human porphobilinogen deaminase gene: recurrent mutations G111R and R173Q occurring at CpG motifs. in Journal of inherited metabolic disease 2005 (PubMed)
    Show all 2 references for ABIN667690

More Proteins for Hydroxymethylbilane Synthase (HMBS) Interaction Partners

Arabidopsis thaliana Hydroxymethylbilane Synthase (HMBS) interaction partners

  1. The interactions observed between the two pyrrole rings of the HEMC dipyrromethane cofactor and the active-site residues are highly specific and are most likely to represent the catalytically relevant binding mode.

  2. Porphobilinogen deaminase deficiency alters vegetative and reproductive development and causes lesions in Arabidopsis.

  3. Crystallization and preliminary X-ray characterization of the tetrapyrrole-biosynthetic enzyme porphobilinogen deaminase from Arabidopsis thaliana. [porphobilinogen deaminase]

Human Hydroxymethylbilane Synthase (HMBS) interaction partners

  1. ALAS1 (show ALAS2 Proteins) mRNA and activity were elevated approximately ~3- and 5-fold, and HMB synthase activity was approximately half-normal (~42%)

  2. in the hepatic cancer tissue of two acute porphyria patients, somatic second-hit mutations result in nearly complete inactivation of PPOX and HMBS

  3. study of hydroxymethylbilane synthase mutations and polymorphisms in Brazilian families with acute intermittent porphyria

  4. Letter/Case Report: R173W mutation of HMBS gene can cause rhabdomyolysis in patients with variant acute intermittent porphyria.

  5. we report a novel PBGD missense mutation.

  6. Novel porphobilinogen deaminase gene mutations have been described in Polish patients with non-erythroid acute intermittent porphyria.

  7. Conformational stability and activity of hydroxymethylbilane synthase (HMSB) and the acute intermittent porphyria K132N and V215E HMSB mutations.

  8. Dense geographic aggregation with one identical haplotype strongly suggests a remote founder phenomenon for these Venezuelan acute intermittent porphyria families, carrying an unreported but most frequent HMBS mutation.

  9. Findings indicate that using TATA-binding protein (TBP (show TBP Proteins)) alone or in combination with hydroxymethylbilane synthase (HMBS) as endogenous controls could be a reliable method for normalizing qRT-PCR data in hepatoma cell lines treated with TNF-alpha (show TNF Proteins).

  10. The novel mutations of HMBS gene were three missense (R26L, R173G and D178H), two frameshift (c.749_765dup and c.874insC) and one intronic deletion (IVS12+3_+11delAGGGCCTGT).

Mouse (Murine) Hydroxymethylbilane Synthase (HMBS) interaction partners

  1. Porphobilinogen deaminase over-expression in hepatocytes, albeit in a low proportion, reduced precursor accumulation, which is the hallmark of acute porphyric attacks.

  2. PBGD-deficient mice were characterized biochemically during phenobarbital induction of heme synthesis and enzyme replacement.

Hydroxymethylbilane Synthase (HMBS) Protein Profile

Protein Summary

This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described.

Gene names and symbols associated with HMBS

  • hydroxymethylbilane synthase (HMBS)
  • hydroxymethylbilane synthase (hmbs)
  • hydroxymethylbilane synthase (hmbs.2)
  • hydroxymethylbilane synthase (CNC02250)
  • hydroxymethylbilane synthase (predicted) (hem3)
  • hydroxymethylbilane synthase (hemC)
  • Hydroxymethylbilane synthase (Trad_0335)
  • hydroxymethylbilane synthase (Hmbs)
  • hydroxymethylbilane synthase (Plabr_2100)
  • hydroxymethylbilane synthase (Sgly_3113)
  • Porphobilinogen deaminase (HEMC)
  • porphobilinogen deaminase (hemC)
  • hemC (hemC)
  • porphobilinogen deaminase (Franean1_6130)
  • porphobilinogen deaminase (PBGD1)
  • porphobilinogen deaminase (Mrub_0727)
  • porphobilinogen deaminase (Mrub_1398)
  • Porphobilinogen deaminase (hemC)
  • porphobilinogen deaminase (Arnit_2733)
  • porphobilinogen deaminase (Ndas_4371)
  • porphobilinogen deaminase (Mesil_0353)
  • porphobilinogen deaminase (Mesil_2984)
  • hydroxymethylbilane synthase a (hmbsa)
  • CMS2841 protein
  • DDBDRAFT_0186148 protein
  • DDBDRAFT_0231417 protein
  • DDB_0186148 protein
  • DDB_0231417 protein
  • F8L15.10 protein
  • F8L15_10 protein
  • hemC protein
  • hmbs protein
  • hydroxymethylbilane synthase protein
  • NV50236 protein
  • PBG-D protein
  • PBGD protein
  • popE protein
  • PORC protein
  • PORPHOBILINOGEN DEAMINASE protein
  • SPAC806.01 protein
  • T25658 protein
  • Ups protein
  • URO-S protein
  • Uros1 protein
  • zgc:64128 protein

Protein level used designations for HMBS

porphobilinogen deaminase , hydroxymethylbilane synthase , Hydroxymethylbilane synthase , porphobilinogen deaminase-like , Porphobilinogen deaminase , porphyria, acute; Chester type , pre-uroporphyrinogen synthase , uroporphyrinogen I synthase , uroporphyrinogen I synthetase , PBG-D , alternative name: porphobilinogen deaminase

GENE ID SPECIES
419701 Gallus gallus
448096 Xenopus (Silurana) tropicalis
495094 Xenopus laevis
702943 Macaca mulatta
3256245 Cryptococcus neoformans var. neoformans JEC21
3361383 Schizosaccharomyces pombe 972h-
8250098 Micromonas sp. RCC299
8624733 Dictyostelium discoideum AX4
9279308 Truepera radiovictrix DSM 17093
9350137 Helicobacter pylori B8
100121374 Nasonia vitripennis
10239509 Planctomyces brasiliensis DSM 5305
10250332 Syntrophobotulus glycolicus DSM 8271
100446876 Pongo abelii
830724 Arabidopsis thaliana
887306 Mycobacterium tuberculosis H37Rv
904871 Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819
1064946 Tropheryma whipplei TW08/27
1176684 Yersinia pestis CO92
1794978 Rhodopirellula baltica SH 1
2650205 Corynebacterium diphtheriae NCTC 13129
2662220 Bordetella bronchiseptica RB50
2860702 Staphylococcus aureus subsp. aureus MRSA252
2863981 Staphylococcus aureus subsp. aureus MSSA476
2885596 Pectobacterium atrosepticum SCRI1043
3233359 Ehrlichia ruminantium str. Welgevonden
4714897 Yersinia enterocolitica subsp. enterocolitica 8081
5175406 Clavibacter michiganensis subsp. michiganensis NCPPB 382
5185175 Clostridium botulinum A str. ATCC 3502
5674451 Frankia sp. EAN1pec
5727029 Chlamydomonas reinhardtii
6158370 Clavibacter michiganensis subsp. sepedonicus
6395026 Stenotrophomonas maltophilia K279a
6801447 Proteus mirabilis HI4320
6932678 Burkholderia cenocepacia J2315
6988643 Aliivibrio salmonicida LFI1238
7707286 Gemmatimonas aurantiaca T-27
8878808 Meiothermus ruber DSM 1279
8879495 Meiothermus ruber DSM 1279
8951204 Erwinia amylovora ATCC 49946
8995997 Salinibacter ruber M8
9172929 Arcobacter nitrofigilis DSM 7299
9248246 Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111
9249835 Meiothermus silvanus DSM 9946
9252507 Meiothermus silvanus DSM 9946
734761 Xenopus laevis
3145 Homo sapiens
489373 Canis lupus familiaris
396581 Sus scrofa
515614 Bos taurus
15288 Mus musculus
25709 Rattus norvegicus
394129 Danio rerio
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