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Hydroxysteroid (11-Beta) Dehydrogenase 2 Proteins (HSD11B2)

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. Additionally we are shipping Hydroxysteroid (11-Beta) Dehydrogenase 2 Antibodies (88) and Hydroxysteroid (11-Beta) Dehydrogenase 2 Kits (22) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSD11B2 3291 P80365
HSD11B2 15484 P51661
HSD11B2 25117 P50233
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Top Hydroxysteroid (11-Beta) Dehydrogenase 2 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,107.50
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$3,120.33
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$3,125.83
Details
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
$3,191.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

HSD11B2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Interaction Partners

Human Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. zearalenone is a selective inhibitor of HSD11B2, implying that this agent may cause excessive glucocorticoid action in local tissues such as kidney and placentas.

  2. Infants with the high-risk neurobehavioral profile showed more methylation than infants with the low-risk neurobehavioral profile at CpG3 for NR3C1 (show NR3C1 Proteins) and less methylation of CpG3 for HSD11B2.

  3. growth potential of fetus related to the 11beta-HSD2 expression in the placenta, and 11beta-HSD2 expression related to the trace metals status of the mother

  4. maternal depression and anxiety may impact on fetal programming by down-regulating HSD11B2, and antidepressant treatment alone is unlikely to protect against this effect.

  5. Data show that glucocorticoid response genes NR3C1 (show NR3C1 Proteins), ADCYAP1R1 (show ADCYAP1R1 Proteins) and HSD11B2 were relatively hypomethylated whereas FKBP5 (show FKBP5 Proteins) was hypermethylated.

  6. No interaction was found between HSD11B2 and exposure during pregnancy, but individuals with the A allele of rs5479 had an increased risk of schizophrenia after exposure at age 3-9 years

  7. 11betaHSD2 inhibition suppressed lung tumor growth and invasion in association with increased tissue active glucocorticoid levels, decreased COX-2 expression, inhibition of ERK (show EPHB2 Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.

  8. Our work is one of the first comprehensive views of DNA methylation (show HELLS Proteins) and expression in the placenta for both HSD11B (show HSD11B1 Proteins) types 1 and 2, linking epigenetic alterations with the regulation of fetal stress and birth weight outcomes.

  9. A novel HSD11B2 functional mutation accounting for an Ala221Gly substitution causes Apparent mineralocorticoid excess. The hypertension phenotype is also epigenetically modulated by HSD11B2 methylation in subjects heterozygous for the mutation

  10. infants with low NR3C1 (show NR3C1 Proteins) methylation but high HSD11B2 methylation had lower excitability scores; those with high NR3C1 (show NR3C1 Proteins) methylation but low HSD11B2 methylation had more asymmetrical reflexes

Pig (Porcine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. These results indicate that the effects of maternal protein restriction on placental 11beta-HSD2 expression are gender-dependent in the pig, and thyroid hormones may be involved in such effects.

  2. Postnatal ontogeny of 11beta-HSD2 gene expression is described for the first time in stress-related brain regions of domestic pigs at 7, 21, and 35 days of age.

  3. concluded that the 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 (show HSD11B1 Proteins) and 2) system is involved in the regulation of cortisol activity in the testis and thus in the regulation of spermatogenesis

  4. Effects of age, weaning and/or social isolation on the expression of genes regulating HSD11B2.

  5. The expression of 11beta-HSD2 in several types of cells forms consecutive lines of defense may protect spermatogonia against glucocorticoid-induced apoptosis.

  6. 11beta-HSD (show HAL Proteins) type 2, which is abundantly expressed, plays important roles in cortisol inactivation in pig Leydig cells.

  7. The amount of 11beta-HSD 2 in germ cells was greatest at birth, decreased thereafter and was absent after Week 3.

Cow (Bovine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. investigation of expression for 11HSD1, 11HSD2, and glucocorticoid receptor (show NR3C1 Proteins) during follicular maturation and atresia: in atretic follicles, expression of 11HSD2 increased in both granulosa cells and theca interna layers

Mouse (Murine) Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) interaction partners

  1. Reduced brain 11betaHSD2 promotes a hunger for salt and salt sensitivity. 11betaHSD2-positive neurons integrate salt appetite and the blood pressure response to dietary sodium through a mineralocorticoid receptor (show NR3C2 Proteins)-dependent pathway.

  2. 11betaHSD2 inhibition suppressed lung tumor growth and invasion in association with increased tissue active glucocorticoid levels, decreased COX-2 expression, inhibition of ERK (show EPHB2 Proteins) and mTOR (show FRAP1 Proteins) signaling pathways.

  3. results show that intestinal epithelial 11ssHSD2 activity contributes to increased COX-2 expression in Apc (show APC Proteins)+/min intestinal adenomas and that 11ssHSD2 deficiency in intestinal epithelial cells suppresses adenoma development and growth

  4. 11beta-hydroxysteroid dehydrogenase-2 is a cortisol-inactivating enzyme with a role in keratinocyte cell proliferation and basal cell proliferation

  5. Reduced 11beta-hydroxysteroid dehydrogenase type 2 causes salt sensitivity of blood pressure because of impaired renal natriuretic capacity.

  6. findings implicate DNA methylation (show HELLS Proteins) as a mechanism by which prenatal stress alters HSD11B2 gene expression

  7. This study found that 11beta-hydroxysteroid dehydrogenase type 2 knockout mice develop nephrogenic diabetes insipidus.

  8. HSD2 inhibition and increasing corticosterone adult physiological levels both can independently upregulate neural progenitor cell apoptosis in the perinatal period.

  9. 11beta-HSD2 plays no role in acute inflammatory responses

  10. Prenatal exposure to ethanol reduced expression of placental 11beta-HSD-2.

Hydroxysteroid (11-Beta) Dehydrogenase 2 (HSD11B2) Protein Profile

Protein Summary

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

Gene names and symbols associated with HSD11B2

  • hydroxysteroid (11-beta) dehydrogenase 2 (hsd11b2)
  • hydroxysteroid (11-beta) dehydrogenase 2 (HSD11B2)
  • hydroxysteroid 11-beta dehydrogenase 2 (Hsd11b2)
  • NAD-dependent 11-beta-hydroxysteroid dehydrogenase (HSD11K)
  • 11-HSD2 protein
  • 11HSD2 protein
  • AME protein
  • AME1 protein
  • HSD2 protein
  • HSD11B2 protein
  • HSD11K protein
  • MGC81883 protein
  • SDR9C3 protein

Protein level used designations for HSD11B2

hydroxysteroid (11-beta) dehydrogenase 2 , corticosteroid 11-beta-dehydrogenase isozyme 2 , 11 beta-hydroxysteroid dehydrogenase type 2 , -HSD11 type II , 11-DH2 , 11-beta-HSD2 , 11-beta-hydroxysteroid dehydrogenase type 2 , 11-beta-hydroxysteroid dehydrogenase type II , NAD-dependent 11-beta-hydroxysteroid dehydrogenase , short chain dehydrogenase/reductase family 9C member 3 , 11-beta hydroxysteroid dehydrogenase , hydroxysteroid 11-beta dehydrogenase 2 , 11-beta-hydroxysteroid dehydrogenase 2 , 11(beta)-HSD2 , Hydroxysteroid dehydrogenase, 11 beta type 2

GENE ID SPECIES
444491 Xenopus laevis
100034124 Equus caballus
100529249 Felis catus
3291 Homo sapiens
396948 Sus scrofa
282434 Bos taurus
100009531 Oryctolagus cuniculus
489758 Canis lupus familiaris
15484 Mus musculus
25117 Rattus norvegicus
443530 Ovis aries
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