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Hydroxysteroid (17-Beta) Dehydrogenase 12 Proteins (HSD17B12)

HSD17B12 encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. Additionally we are shipping HSD17B12 Antibodies (42) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HSD17B12 51144 Q53GQ0
HSD17B12 56348 O70503
Rat HSD17B12 HSD17B12 84013 Q6P7R8
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Top HSD17B12 Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

HSD17B12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12) Interaction Partners

Human Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12) interaction partners

  1. Significant associations have been found between CpG sites and patient sex, including DNA methylation (show HELLS Proteins) in CASP6 (show CASP6 Proteins), a gene that may respond to estradiol treatment, and in HSD17B12, which encodes a sex steroid hormone.

  2. These evidences were suggestive of a 46,XY DSD (show FADS1 Proteins) due to 17betaHSD3 deficiency. An homozygous mutation (IVS3 -1 G>C or c.326-1G>C) of the 17betaHSD3 gene was discovered.

  3. HSD17B12 overexpression is shown to be a marker of poor survival in patients with ovarian cancer; expression in the tumor and function of this enzyme facilitates ovarian cancer progression.

  4. High HSD17B12 expression is associated with neoplasms.

  5. 17beta-HSD12 is the major estrogenic 17beta-HSD (show HSD17B3 Proteins) responsible for the conversion of E1 to E2 in women.

  6. Location of 17beta-hydroxysteroid dehydrogenase (show HSD17B7 Proteins) type 12 through the human body.

  7. determined the activity and expression levels of known estrogenic 17beta-HSDs, namely types 1, 7 and 12 17beta-HSD (show HSD17B3 Proteins) in preadipocytes before and after differentiation into mature adipocytes

  8. There is no difference in catalytic properties between variants of 17beta-HSD (show HSD17B3 Proteins) types 7 and 12 and wild-type enzymes, while variants p.Glu77Gly and p.Lys183Arg in 17beta-HSD (show HSD17B3 Proteins) type 5 showed a slightly decreased activity.

  9. SREBP-1 (show SREBF1 Proteins) represents one of the transcriptional regulators of human 17beta-HSD12.

Mouse (Murine) Hydroxysteroid (17-Beta) Dehydrogenase 12 (HSD17B12) interaction partners

  1. Hsd17b12 is essential for mouse organogenesis and embryonic survival.

HSD17B12 Protein Profile

Protein Summary

This gene encodes a very important 17beta-hydroxysteroid dehydrogenase (17beta-HSD) that converts estrone into estradiol in ovarian tissue. This enzyme is also involved in fatty acid elongation.

Gene names and symbols associated with HSD17B12

  • hydroxysteroid (17-beta) dehydrogenase 12 (HSD17B12)
  • hydroxysteroid (17-beta) dehydrogenase 12 (LOC100346603)
  • hydroxysteroid (17-beta) dehydrogenase 12 (Hsd17b12)
  • 2610510O05Rik protein
  • AI172963 protein
  • HSD17B12 protein
  • KAR protein
  • KIK-I protein
  • Kik1 protein
  • SDR12C1 protein

Protein level used designations for HSD17B12

hydroxysteroid (17-beta) dehydrogenase 12 , steroid dehydrogenase homolog , 17-beta-HSD 12 , 17-beta-hydroxysteroid dehydrogenase 12 , 17beta-HSD type 12 , 3-ketoacyl-CoA reductase , estradiol 17-beta-dehydrogenase 12 , short chain dehydrogenase/reductase family 12C, member 1 , KAR , keratoadhesin , keratonectin , steroid dehydrogenase , smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3

GENE ID SPECIES
475939 Canis lupus familiaris
616219 Bos taurus
741010 Pan troglodytes
770297 Gallus gallus
100312972 Sus scrofa
100346603 Oryctolagus cuniculus
51144 Homo sapiens
56348 Mus musculus
84013 Rattus norvegicus
789567 Bos taurus
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