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anti-Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) Antibodies

The protein encoded by HSD17B4 is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. Additionally we are shipping HSD17B4 Proteins (8) and HSD17B4 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HSD17B4 3295 P51659
HSD17B4 15488 P51660
HSD17B4 79244 P97852
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Top anti-HSD17B4 Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with 17-beta-HSD4 / HSD17B4 Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of 17-beta-HSD4 / HSD17B4 Antibody (Center) in MCF-7, ZR-75-1, HepG2 cell line lysates (35ug/lane). This demonstrates the HSD17B4 antibody detected the HSD17B4 protein (arrow). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB HSD17B4 Antibody (Center)  western blot analysis in MCF-7,ZR-75-1,HepG2 cell line lysates (35ug/lane).This demonstrates the HSD17B4 antibody detected the HSD17B4 protein (arrow). HSD17B4 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of HSD17B4 Antibody (Center) for immunohistochemistry.  Clinical relevance has not been evaluated. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 2 to 3 Days
$283.50
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-Hydroxysteroid(17-beta) Dehydrogenase 4 antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue Lane 8: COLO320 Cell Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of HSD17B4 expression in HEK293T (A), Raw264.7 (B), PC12 (C) whole cell lysates. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded DLD-1 xenograft , using HSD17B4, antibody at 1:500 dilution. WB Image HSD17B4 antibody detects HSD17B4 protein by Western blot analysis. A. 20 ug Rat heart lysate/extract 7.5% SDS-PAGE HSD17B4 antibody , dilution: 1:3000 100 μL Log in to see 2 to 3 Days
$358.60
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$683.83
Details
Human Rabbit Un-conjugated IHC (p), WB   100 μg Log in to see 8 to 10 Days
$463.83
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded human ovarian cancer, using HSD17B4, antibody at 1:500 dilution. WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Log in to see 2 to 3 Days
$358.60
Details

HSD17B4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-HSD17B4 Antibodies

  1. Human Polyclonal HSD17B4 Primary Antibody for EIA, IHC (p) - ABIN950184 : Kashiwayama, Tomohiro, Narita, Suzumura, Glumoff, Hiltunen, Van Veldhoven, Hatanaka, Imanaka: Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative. in The Journal of biological chemistry 2010 (PubMed)
    Show all 4 references for ABIN950184

More Antibodies against HSD17B4 Interaction Partners

Zebrafish Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. The knockdown of dbp (show GC Antibodies) in zebrafish phenocopied clinical manifestations of its deficiency in human.

Fruit Fly (Drosophila melanogaster) Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP (show UCN3 Antibodies)-2L (sterol carrier protein 2 (show SCP2 Antibodies)-like) domain in human and C. elegans proteins.

Human Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. Results show that HSD17B4 is highly expressed in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells and activated NF-kappaB (show NFKB1 Antibodies) co-localized with the NF-kappaB (show NFKB1 Antibodies)-responsive element of HSD17B4 suggesting that HSD17B4 plays an important role in aggravated HCC (show FAM126A Antibodies) progression.

  2. Structural MFE-2 instability is the molecular basis of D-bifunctional protein deficiency type III.

  3. Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase (show HSD17B7 Antibodies) type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency.

  4. Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP (show RAG1AP1 Antibodies)-2L (sterol carrier protein 2 (show SCP2 Antibodies)-like) domain in human and C. elegans proteins.

  5. Epistasis between the HSD17B4 and thyroglobulin (show TG Antibodies) polymorphisms is associated with premature ovarian failure. A haplotype in the HSD17B4 gene was identified that was significantly associated with resistance to POF (show POF1B Antibodies)

  6. The diagnosis of a type III DBPD with a missense mutation (T15A) in the HSD17B4 gene, coding for D-bifunctional protein (DBP), could be established.

  7. MFE2 anchors its substrate around the region from Trp(249) to Arg(251) and positions the substrate along the hydrophobic cavity in the proper direction toward the catalytic center

  8. Perrault syndrome and DBP (show GC Antibodies) deficiency overlap clinically and Perrault syndrome is genetically heterogeneous.

  9. rs11205 in HSD17B4 was associated with testicular germ cell tumor. Risk doubled per copy of the minor A allele. Homozygosity of this allele quadrupled the risk vs. homozygous major G allele. The risk was increased both for seminoma & nonseminoma.

  10. crystal structure of 2-enoyl-CoA hydratase 2

Mouse (Murine) Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation in mice.

  2. bile acid biosynthesis, estimated by the ratio of C27/C24-bile acids, is more severely affected in double knock-out mice as compared with DBP (show GC Antibodies)-/- mice but was normal in LBP (show LBP Antibodies)-/- mice

  3. Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility

  4. Loss of MFP2 leads to attenuation of up-regulations of SREBP2 (show SREBF2 Antibodies) and HMGCR (show HMGCR Antibodies) involved in cholesterol synthesis.

Pig (Porcine) Hydroxysteroid (17-Beta) Dehydrogenase 4 (HSD17B4) interaction partners

  1. Leptin (show LEP Antibodies) in elevated doses, by stimulatory effect on CYP11A1 (show CYP11A1 Antibodies) and 17b-HSD (show HAL Antibodies) protein expression resulting in elevated P(4) and testosterone secretions could be an independent risk factor for cyst formation in both prepubertal and cycling pigs.

HSD17B4 Antigen Profile

Protein Summary

The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.

Gene names and symbols associated with HSD17B4

  • hydroxysteroid (17-beta) dehydrogenase 4 (hsd17b4) antibody
  • hydroxysteroid (17-beta) dehydrogenase 4 (HSD17B4) antibody
  • peroxisomal Multifunctional enzyme type 2 (Mfe2) antibody
  • hydroxysteroid (17-beta) dehydrogenase 4 (Hsd17b4) antibody
  • 4 antibody
  • 17-beta-HSD antibody
  • 17[b]-HSD antibody
  • CG3415 antibody
  • DBP antibody
  • Dmel\\CG3415 antibody
  • DmMFE-2 antibody
  • MFE-2 antibody
  • Mfp-2 antibody
  • MFP2 antibody
  • MPF-2 antibody
  • perMFE-2 antibody
  • PRLTS1 antibody
  • SDR8C1 antibody
  • zgc:55545 antibody
  • zgc:77300 antibody

Protein level used designations for HSD17B4

peroxisomal multifunctional enzyme type 2 , CG3415-PA , Mfe2-PA , 17-beta-HSD 4 , 17-beta-HSD IV , 17-beta-hydroxysteroid dehydrogenase 4 , 17beta-estradiol dehydrogenase type IV , 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase , D-3-hydroxyacyl-CoA dehydratase , D-bifunctional protein, peroxisomal , beta-hydroxyacyl dehydrogenase , beta-keto-reductase , multifunctional protein 2 , peroxisomal multifunctional protein 2 , short chain dehydrogenase/reductase family 8C, member 1 , D-bifunctional protein , DBP , MFE-2 , peroxisomal multifunctional enzyme type II , 17-beta-hydroxysteroid dehydrogenase type IV , 17beta-estradiol dehydrogenase , mutifunctional protein2

GENE ID SPECIES
393105 Danio rerio
474630 Canis lupus familiaris
32582 Drosophila melanogaster
3295 Homo sapiens
15488 Mus musculus
79244 Rattus norvegicus
395785 Gallus gallus
397574 Sus scrofa
493643 Bos taurus
100379226 Cavia porcellus
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