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Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.[supplied by OMIM, Jul 2010].. Additionally we are shipping HCN2 Antibodies (68) and HCN2 Kits (4) and many more products for this protein.
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Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm.
Data show that Rab8b (show RAB8B Proteins)-interacting protein TRIP8b does not compete with cyclic AMP (show APRT Proteins) for the same binding region of hyperpolarization activated cyclic nucleotide gated potassium channel 2 (HCN2).
N-glycosylation is not required for HCN2 channels to function.
Thermal hyperalgesia under chronic inflammatory conditions is mediated by HCN2 channels.
Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner.
HCN2 polymorphism may play a role in chronic inflammatory periodontitis but not in peri (show PLIN1 Proteins)-implantitis.
LBB-injected HCN2/SkM1 (show SCN4A Proteins) potentially provides a more clinically suitable biological pacemaker strategy than other reported constructs. This superiority is attributable to the more negative AP threshold and injection into the LBB
HCN2 channels make an important contribution to the maintenance of spontaneous burst activity in embryonic cortical neuron cultures.
This is the first evidence in humans for a single-point, homozygous loss-of-function mutation in HCN2 potentially associated with generalized epilepsy with recessive inheritance.
Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 (show HCN1 Proteins) , HCN2, HCN3 (show HCN3 Proteins) and HCN4 (show HCN4 Proteins).
the allosteric mechanism of different cyclic nucleotides on the cyclic nucleotide-binding domain of HCN2 and on channel gating, was investigated.
HCN1 (show HCN1 Proteins), HCN2, and HCN4 (show HCN3 Proteins) subunits may have distinct physiological roles in the developing hippocampus.
HCN2 channel activity reduces the repolarization reserve of the ventricular action potential and increases ectopic automaticity under pathological conditions such as excessive beta-adrenergic stimulation.
This study demonstrated that Increased expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in reactive astrocytes following ischemia.
fisetin is a partial agonist for HCN2 channels.
HCN2 channel expression increases significantly during pregnancy, accelerating the heart rate.
cAMP-dependent changes in the structure of the C-helix of a C-terminal fragment of HCN2 channels
Dendritic expression of the h-channel subunit HCN1 (show HCN1 Proteins), but not HCN2, was higher in the CA1 (show CA1 Proteins) region of fmr1 (show FMR1 Proteins)(-/y) mice.
Leucine zipper motif essential for gating of HCN1 (show HCN1 Proteins) and HCN2.
Data indicate that HCN1 (show HCN1 Proteins) and HCN2 form alternate ternary protein complexes with hair-cell stereociliary proteins.
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain.
hippocampus abundant transcript 1
, hippocampus abundant transcript 1 protein
, hyperpolarization activated cyclic nucleotide-gated potassium channel 2
, brain cyclic nucleotide gated channel 2
, brain cyclic nucleotide-gated channel 2
, potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
, hyperpolarization-activated cation channel 1