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Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 Proteins (HCN4)

HCN4 encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. Additionally we are shipping HCN4 Antibodies (54) and HCN4 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HCN4 10021 Q9Y3Q4
Rat HCN4 HCN4 59266 Q9JKA7
HCN4 330953  
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Top HCN4 Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

HCN4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) Interaction Partners

Human Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. Our results confirm the genetic evidence for the involvement of the HCN4 mutations in the combined bradycardia-non compaction cardiomyopathy phenotype and illustrates that.

  2. Aged patients with sinus rhythm exhibited significantly higher expression levels of HCN2 and HCN4 channel mRNA and protein (P<0.05), but significantly lower expression levels of miR1 and 133, compared with those of adult patients with sinus rhythm.

  3. study establishes the role of f-channels in cardiac automaticity and indicates that arrhythmia related to HCN loss-of-function may be managed by pharmacological or genetic inhibition of GIRK4 (show KCNJ5 Proteins) channels

  4. The study analyzed HCN4 intracellular region dynamics in the four states of the thermodynamic cycle arising from the coupling between cAMP binding and tetramerization equilibria.

  5. study identified a novel trafficking-defective mutation in the amino-terminus of HCN4 channel in individuals with early-onset atrial fibrillation (AF); findings support that novel loss-of-function mutations in the HCN4 channel may increase susceptibility and have a role in AF pathogenesis

  6. used NMR to probe the changes caused by the binding of cAMP and of cCMP, a partial agonist, to the apo (show C9orf3 Proteins)-cAMP-binding domain of HCN4

  7. Here, we review the changes in expression and kinetics of HCN4 mutant channels and provide an overview of their effects on If during the time course of a human SAN action potential, both under resting conditions and upon adrenergic stimulation. [review]

  8. The HCN4-G1097W mutant channels displayed a loss-of-function type modulation on cardiac If channels and thus could predispose them to AV nodal dysfunction. These data provide a novel insight into the genetic basis for the AV block.

  9. Mutations in ion channel gene HCN4 may be associated with structural abnormalities of the myocardium.

  10. The symptom complex of sinus node dysfunction and noncompaction cardiomyopathy is associated with heritable HCN4 defects.

Rabbit Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. Ischemia-reperfusion is harmful to the sinoatrial node and reduces the expression of HCN4.

  2. SAP97 contributes to isoform specific organization of HCN channels within specific domains in the sinoatrial node of the rabbit.

  3. HCN protein expression in the rabbit pacemaker region, was investigated.

Mouse (Murine) Hyperpolarization Activated Cyclic Nucleotide-Gated Potassium Channel 4 (HCN4) interaction partners

  1. beating rate of hiPSC-CMs (show Cd2ap Proteins) co-cultured with aggregates of HCN4 (show HCN3 Proteins)-overexpressing mESC-CMs (show Cd2ap Proteins) was significantly higher than that of non-treated hiPSC-CMs (show Cd2ap Proteins) and that of hiPSC-CMs (show Cd2ap Proteins) co-cultured with aggregates of non-overexpressing mESC-CMs (show Cd2ap Proteins)

  2. study establishes the role of f-channels in cardiac automaticity and indicates that arrhythmia related to HCN loss-of-function may be managed by pharmacological or genetic inhibition of GIRK4 (show KCNJ5 Proteins) channels

  3. HCN1 (show HCN1 Proteins), HCN2 (show HCN2 Proteins), and HCN4 (show HCN3 Proteins) subunits may have distinct physiological roles in the developing hippocampus.

  4. Shox2 (show SHOX2 Proteins) regulates dorsal mesenchymal protrusion fate and development by controlling BMP signaling through the Smad (show SMAD1 Proteins)-dependent pathway to drive tissue growth and to induce Hcn4 (show HCN3 Proteins) expression

  5. HCN4 (show HCN3 Proteins) dynamically marks the first heart field and conduction system precursors.

  6. testosterone induced cardiomyogenesis, at least in part, by recruiting the AR receptor to the regulatory regions of the MEF2C (show MEF2C Proteins) and HCN4 (show HCN3 Proteins) genes.

  7. Data suggest that TRPM7 (show TRPM7 Proteins) influences diastolic membrane depolarization and automaticity in embryonic myocardium and sinoatrial node (SAN) indirectly via regulation of Hcn4 (show HCN3 Proteins) expression.

  8. Cardiomyogenic progenitors derived from the first heart field and human pluripotent stem cells express HCN4 (show HCN3 Proteins).

  9. Spatiotemporal regulation of an Hcn4 (show HCN3 Proteins) enhancer defines a role for Mef2c (show MEF2C Proteins) and HDACs in cardiac electrical patterning.

  10. Suggest that the strongly increased HCN channel activity in hypertrophied myocytes prolongs the repolarization of the ventricular action potential and thereby may increase the arrhythmogenic potential.

HCN4 Protein Profile

Protein Summary

This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15.

Gene names and symbols associated with HCN4

  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4)
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (hcn4)
  • hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (Hcn4)
  • hyperpolarization-activated, cyclic nucleotide-gated K+ 4 (Hcn4)
  • Bcng3 protein
  • HAC4 protein
  • Hcn3 protein
  • SSS2 protein

Protein level used designations for HCN4

hyperpolarization activated cyclic nucleotide-gated potassium channel 4 , hyperpolarization activated cyclic nucleotide-gated cation channel 4 , potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 , hyperpolarization-activated, cyclic nucleotide-gated K+ 4 , HAC-4 , hyperpolarization activated cation channel , hyperpolarization-activated cation channel 4 , BCNG-3 , brain cyclic nucleotide-gated channel 3 , hyperpolarization-activated, cyclic nucleotide-gated K+ 3

GENE ID SPECIES
100544822 Meleagris gallopavo
100560546 Anolis carolinensis
10021 Homo sapiens
59266 Rattus norvegicus
785689 Bos taurus
100009452 Oryctolagus cuniculus
330953 Mus musculus
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