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Hypocretin (Orexin) Receptor 2 Proteins (HCRTR2)

The protein encoded by HCRTR2 is a G-protein coupled receptor involved in the regulation of feeding behavior. Additionally we are shipping HCRTR2 Antibodies (47) and HCRTR2 Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HCRTR2 3062 O43614
Rat HCRTR2 HCRTR2 25605 P56719
HCRTR2 387285 P58308
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Top HCRTR2 Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Wheat germ Human Un-conjugated   2 μg Log in to see 9 Days

HCRTR2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Hypocretin (Orexin) Receptor 2 (HCRTR2) Interaction Partners

Cow (Bovine) Hypocretin (Orexin) Receptor 2 (HCRTR2) interaction partners

  1. These data confirmed expression of orexin and its two receptors in the bovine adrenal gland.

Zebrafish Hypocretin (Orexin) Receptor 2 (HCRTR2) interaction partners

  1. Data show that fish lacking the hypocretin receptor demonstrate short and fragmented sleep in the dark, in striking contrast to the excessive sleepiness and cataplexy of narcolepsy in mammals.

Human Hypocretin (Orexin) Receptor 2 (HCRTR2) interaction partners

  1. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR2 gene.

  2. The study determined structures of OX1R (show HCRTR1 Proteins) bound to the OX1R (show HCRTR1 Proteins)-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution and explored mechanisms of antagonist the subtype selectivity between OX1R (show HCRTR1 Proteins) and OX2R.

  3. our meta-analysis provides genetic evidence for a role of HCRTR2 in cluster headache

  4. Heart failure patients with minor allele for rs7767652, upstream of hypocretin (orexin) receptor-2 (HCRTR2), were less likely to have improved left ventricular function and a lower prevalence of ejection fraction >35%

  5. the nonsynonymous rs2653349 single nucleotide polymorphism (SNP) (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with Fagerstrom Test for Nicotine Dependence.

  6. Antibodies from vaccine-associated narcolepsy sera cross-reacted with both influenza nucleoprotein and hypocretin receptor 2.

  7. using lipid-mediated crystallization and protein engineering with a novel fusion chimaera, the structure of the human OX2R bound to suvorexant at 2.5 A resolution is solved

  8. DQ B1 but not HLA-DR typing, TNF-alpha (show TNF Proteins) levers, HCRTR1 (show HCRTR1 Proteins) and HCRTR2 were higher in narcolepsy-cataplexy/schizophrenia patients.

  9. Both orexin receptor subtypes, OX1R (show HCRTR1 Proteins) and OX2R, and CB1 (show CNR1 Proteins) cannabinoid receptors are capable of forming constitutive homo- and heteromeric complexes.

  10. Orexinergic innervation and expression of genes encoding OX2R receptor are upregulated in transgenic mice at dusk.

Mouse (Murine) Hypocretin (Orexin) Receptor 2 (HCRTR2) interaction partners

  1. Elevation levels of OX1R (show HCRTR1 Proteins) and OX2R (show CD200R1 Proteins) following experimental autoimmune encephalomyelitis induction suggest that alteration in orexinergic system may involve in pathogenesis of multiple sclerosis.

  2. In an heart failure model, HCRTR2-deficient mice exhibited poorer cardiac function, worse treadmill exercise capacity, and greater myocardial scarring

  3. orexin activation of OX2R (show CD200R1 Proteins) in the brain centrally enhances bone formation by lowing circulating leptin (show LEP Proteins) level.

  4. OX2R (show CD200R1 Proteins) activation induces PKC-mediated ERK (show EPHB2 Proteins) and CREB (show CREB1 Proteins) phosphorylation.

  5. In the hypothalamus, the OX2 receptors have an inhibitory role in modulating basal concentrations of NE, ACh, and Hist. In the prefrontal cortex, the evoked release of the monoamines NE, 5-HT, and DA seems to be controlled negatively by OX2 receptors.

  6. results indicate that hcrtr1 (show HCRTR1 Proteins) and 2 signaling oppose one another in the regulation of depression-like behaviors.

  7. Mice lacking OX2R (show CD200R1 Proteins) signaling had poor maintenance of wakefulness indicative of sleepiness and fragmented sleep and lacked any electrophysiological response to orexin-A in the wake-promoting neurons of the tuberomammillary nucleus.

  8. activation of orexin neurons through OX2R (show CD200R1 Proteins) might have an important role in the maintenance of arousal.

  9. Regulation of sleep/wake states is completely achieved by OX(2)R-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1 (show NQO1 Proteins)) receptors.

  10. So, the SAF (show PGS1 Proteins) diet can alter adipocytic adiposity-related gene expression and result in effective amelioration of diet-induced obesity.

Pig (Porcine) Hypocretin (Orexin) Receptor 2 (HCRTR2) interaction partners

  1. Immunoreactivity (IR) for both orexins A and B (OXA and OXB), and cognate receptors (OX1R (show HCRTR1 Proteins) and OX2R) were identified only in the excretory striated (show NSDHL Proteins) ducts of the MSG while acinar cells were not immunoreactive.

  2. Data demonstrated the presence of OX1R (show HCRTR1 Proteins) and OX2R genes and proteins in the ovary of the pig and the impact of the hormonal milieu on the expression of both receptors.

  3. expression of OX1R (show HCRTR1 Proteins) and Ox2R in hypothalamus during oestrous cycle; evidence OX1R (show HCRTR1 Proteins) and OX2R mRNAs and proteins occur in hypothalamic structures engaged in control of reproduction; indicate dependence of OXR expression on endocrine reproductive state

  4. findings provide the first evidence that orexin receptors 1 and 2 messenger RNAs and proteins occur in the pituitary of the pig and indicate the dependence of orexin receptor expression on the endocrine reproductive state

HCRTR2 Protein Profile

Protein Summary

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A.

Gene names and symbols associated with HCRTR2

  • hypocretin (orexin) receptor 2 (HCRTR2)
  • hypocretin (orexin) receptor 2 (LOC100229747)
  • hypocretin (orexin) receptor 2 (hcrtr2)
  • orexin receptor 2 (LOC443181)
  • hypocretin (orexin) receptor 2 (Hcrtr2)
  • hcrtr protein
  • LOC443181 protein
  • LOC100229747 protein
  • mOX2aR protein
  • mOX2bR protein
  • mOXR2 protein
  • OX2R protein

Protein level used designations for HCRTR2

orexin receptor type 2 , hypocretin (orexin) receptor 2 , orexin receptor type 2-like , hypocretin receptor 2 , orexin receptor 2 , hcrt receptor , hypocretin orexin receptor , hypocretin receptor , hypocretin receptor type 2 , orexin type-2 receptor , ox-2-R , ox2-R , hypocretin/orexin (Hcrt) receptor 2 , ox2R , ox2r

529603 Bos taurus
100229747 Taeniopygia guttata
100392404 Callithrix jacchus
100457334 Pongo abelii
100495420 Xenopus (Silurana) tropicalis
100603910 Nomascus leucogenys
428644 Gallus gallus
443181 Ovis aries
462786 Pan troglodytes
561260 Danio rerio
3062 Homo sapiens
399545 Canis lupus familiaris
25605 Rattus norvegicus
387285 Mus musculus
397428 Sus scrofa
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