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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Antibodies

HIF1A encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. Additionally we are shipping Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Kits (62) and Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (50) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HIF1A 15251 Q61221
HIF1A 3091 Q16665
Anti-Rat HIF1A HIF1A 29560 O35800
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Top anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Antibodies at antibodies-online.com

Showing 10 out of 664 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB Sample Type: Chicken Liver Nuclei (50ug)Primary Dilution: 1:1000Secondary Antibody: goat anti-rabbit HRPSecondary Dilution: 1:2000Image Submitted By: Silvia MooreWeill Cornell Medical College 100 μL Log in to see 2 to 3 Days
$289.00
Details
Hamster Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of HIF1A Antibody (N-term) (ABIN650972) in CHO cell line lysates (35 µg/lane). HIF1A (arrow) was detected using the purified polyclonal antibody. HIF1A Antibody (N-term)(ABIN650972) IHC analysis in formalin fixed and paraffin embedded lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of HIF1Alpha Antibody (Center) (ABIN652389) in mouse NIH-3T3 cell line lysates (35 µg/lane). HIF1Alpha (arrow) was detected using the purified polyclonal antibody. HIF1Alpha Antibody (Center)(ABIN652389) IHC analysis in formalin fixed and paraffin embedded lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Mouse Un-conjugated ChIP, ELISA, FACS, GS, ICC, IF, IHC, IHC (fro), IHC (p), IP, Act (ligand), S, WB Immunohistochemistry staining of human glioblastoma multiforme Western Blot analysis of 50ug cobalt chloride induced COS-7 nuclear extracts (NB800-PC26) 0.1 mL Log in to see 5 to 7 Days
$473.81
Details
Cow Mouse Un-conjugated ICC, IF, IHC, IHC (fro), IHC (p), IP, SimWes, WB Negative control stain of human placenta (from sea level) using mouse IgG at 1:100. Human placenta 0.1 mL Log in to see 5 to 7 Days
$473.81
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of HIF1Alpha Antibody (C-term) (ABIN392176) in MDA-MB231 cell line lysates (35 µg/lane). HIF1Alpha (arrow) was detected using the purified polyclonal antibody. Western blot analysis of HIF1Alpha Antibody (C-term) (ABIN392176) in mouse cerebellum tissue lysates (35 µg/lane). HIF1Alpha (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Mouse Un-conjugated ICC, IF, IHC, ELISA, WB HIF1alpha (EP190b), Mosue backskin. Hif1alpha WB 1 in 500 in Hela 20ug untreated 100 μg Log in to see 3 to 4 Days
$349.80
Details
Human Rabbit Un-conjugated SimWes, WB Simple Western: HIF-1 alpha Antibody [NBP1-02160] - Simple Western lane view shows a specific band for HIF-1 alpha in 0.5 mg/ml of Hypoxic HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. Western Blot: HIF-1 alpha Antibody [NBP1-02160] - Detection of HIF-1 alpha using NBP1-02160. Lane 1: COS7 CoCl treated cells Lane 2: COS7 untreated cells. 0.1 mL Log in to see 5 to 7 Days
$408.19
Details
Human Mouse Un-conjugated IHC (p), IP, IHC, WB Figure 1 illustrates Westerm blot detection of HIF-1 alpha  (125-130 kDa) from human placental villous explant total protein using ABIN151762. (explants were subjected to 21 and 2% oxygen for 4 hours) using ABIN151428. Immunohistochemistry-Paraffin: HIF-1 alpha Antibody (HA111) [ABIN151762] - HIF-1 antibody was tested in human ovarian cancer tumor xenograft using DAB with hematoxylin counterstain. 0.1 mL Log in to see 5 to 7 Days
$408.19
Details

HIF1A Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Antibodies

  1. Cow (Bovine) Monoclonal HIF1A Primary Antibody for ChIP, ELISA - ABIN151032 : Bernhardt, Câmpean, Kany, Jürgensen, Weidemann, Warnecke, Arend, Klaus, Günzler, Amann, Willam, Wiesener, Eckardt: Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. in Journal of the American Society of Nephrology : JASN 2006 (PubMed)
    Show all 639 references for ABIN151032

  2. Cow (Bovine) Monoclonal HIF1A Primary Antibody for ICC, IF - ABIN151061 : Abbate, Santini, Biondi-Zoccai, Scarpa, Vasaturo, Liuzzo, Bussani, Silvestri, Baldi, Crea, Biasucci, Baldi: Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe? in Heart (British Cardiac Society) 2004 (PubMed)
    Show all 56 references for ABIN151061

  3. Cow (Bovine) Monoclonal HIF1A Primary Antibody for ICC, IF - ABIN863097 : Surazynski, Miltyk, Prokop, Palka: The effect of estrogen on prolidase-dependent regulation of HIF-1α expression in breast cancer cells. in Molecular and cellular biochemistry 2013 (PubMed)
    Show all 9 references for ABIN863097

  4. Human Monoclonal HIF1A Primary Antibody for IHC (p), IP - ABIN151762 : Gillespie, Whang, Ragel, Flynn, Kelly, Jensen: Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007 (PubMed)
    Show all 6 references for ABIN151762

  5. Human Polyclonal HIF1A Primary Antibody for SimWes, WB - ABIN314828 : Huang, Zitta, Bein, Steinfath, Albrecht: An insert-based enzymatic cell culture system to rapidly and reversibly induce hypoxia: investigations of hypoxia-induced cell damage, protein expression and phosphorylation in neuronal IMR-32 cells. in Disease models & mechanisms 2013 (PubMed)
    Show all 4 references for ABIN314828

  6. Human Polyclonal HIF1A Primary Antibody for IF, IHC (p) - ABIN392176 : Favaro, Nardo, Persano, Masiero, Moserle, Zamarchi, Rossi, Esposito, Plebani, Sattler, Mann, Mueller-Klieser, Ciminale, Amadori, Indraccolo: Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death. in The American journal of pathology 2008 (PubMed)
    Show all 3 references for ABIN392176

  7. Human Polyclonal HIF1A Primary Antibody for FACS, IF - ABIN652389 : Lee, Lee, Kim, Kim, Jung, Seo, Park, Choi, Yim, Lee, Park, Yoo, Kim, Lee, Kim, Ryeom, Kim, Oh: Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis. in Journal of the National Cancer Institute 2010 (PubMed)
    Show all 2 references for ABIN652389

  8. Human Polyclonal HIF1A Primary Antibody for EIA, IHC (p) - ABIN360059 : Alexandru, Graumann, Smith, Kolawa, Fang, Deshaies: UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. in Cell 2008 (PubMed)
    Show all 2 references for ABIN360059

  9. Chicken Polyclonal HIF1A Primary Antibody for WB - ABIN2780373 : Kitajima, Ide, Ohtsuka, Miyazaki: Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. in Cancer science 2008 (PubMed)

More Antibodies against Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Interaction Partners

Mouse (Murine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. methylation-based regulation of HIF-1alpha stability constitutes another layer of regulation that is independent of previously identified mechanisms.

  2. The in vivo anti-tumoral effect of lenalidomide is enhanced by HIF-1alpha suppression in myeloma cells.

  3. Overall, these data indicate that hypoxia or HIF-1alpha positively regulates MEF expression and function.

  4. our study demonstrated that over-expressing miR (show MLXIP Antibodies)-21 in UCBMSCs could improve neovascularization in Critical limb ischemia (CLI (show CLU Antibodies)) through enhancing HIF-1alpha activity by targeting CHIP, which may hold great therapeutic promise in treating CLI (show CLU Antibodies)

  5. Chronic intermittent hypoxia induced an increase in endoplasmic reticulum stress markers and HIF-1 activity.

  6. Alcoholic hepatitis accelerates early hepatobiliary cancer by increasing stemness and miR (show MLXIP Antibodies)-122-mediated HIF-1alpha activation.

  7. Glrx (show GRX1 Antibodies) ablation stabilizes HIF-1alpha by increasing GSH adducts on Cys (show DNAJC5 Antibodies)(520) promoting in vivo HIF-1alpha stabilization, VEGF-A (show VEGFA Antibodies) production, and revascularization in the ischemic muscles.

  8. RANTES (show CCL5 Antibodies) produced by renal tubular cells act as a key chemokine (show CCL1 Antibodies) in acute kidney injury and HIF-1alpha regulated LncRNA-PRINS might be involved in RANTES (show CCL5 Antibodies) production.

  9. The positive correlation between DeltaR2(*) and HIF-2alpha (show EPAS1 Antibodies), but not HIF-1alpha, suggested potential role of combined BOLD-MRI (show C7ORF49 Antibodies) technique and HIF-1alpha staining in clinical diagnosis of renal carcinoma (show TSC2 Antibodies).

  10. Attenuated HIF-1alpha exacerbates the oxidative stress injury by advanced glycation end products in murine Leydig cells, and contributes to diabetic male infertility

Human Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. PNA-antimiR-182 reduced the levels of NICD (show NOTCH1 Antibodies), Hes1, HIF-1alpha, and p-Akt (show AKT1 Antibodies) in both cell groups, while it augmented the intracellular content of FOXO1 (show FOXO1 Antibodies) and Numb (show NUMB Antibodies) suppressor proteins. In other words, PNA-antimiR-182-mediated upregulation of Numb (show NUMB Antibodies) was associated with downregulation of HIF-1alpha and Hes1. Consequently, downregulation of miR (show MLXIP Antibodies)-182 might find therapeutical value for overcoming trastuzumab resistance

  2. Expression changes of E6 and E7 significantly promoted the protein expression of HIF-1alpha, the expression of both protein and mRNA of GLUT1 (show SLC2A1 Antibodies), but had no effect on the expression of HIF-1alpha mRNA in lung cancer cells.

  3. The structural optimization for branched tail oxyquinolines containing an acetamide bond has been performed in the present study using HIF1 ODD-luc reporter assay.

  4. Increases in gene expression levels of TYMP (show TYMP Antibodies), DPYD (show DPYD Antibodies), and HIF1A in tumor tissues at 7 days after the start of CRT (show SLC6A8 Antibodies) may be useful for predicting the efficacy of CRT (show SLC6A8 Antibodies) including S-1 or UFT

  5. The role of HIF-1-alpha in breast cancer and tumor microenvironment [review]

  6. This study provides new insights into the possible mechanism of TREM-1 (show TREM1 Antibodies) and HIF-1alpha in psoriasis.

  7. RSUME (show RWDD3 Antibodies) affects post-transcriptional expression of HIF-1a by regulating VEGF-A (show VEGFA Antibodies) secretion and pituitary adenoma cells invasiveness.

  8. the expression of HIF-1alpha and antisense HIF in breast cancer tissues versus adjacent noncancer tissues, was investigated.

  9. TGFA (show TGFA Antibodies) expression decreased after 10 and 30min of treatment even when transcription was not inhibited. We found that activation of PI3K (show PIK3CA Antibodies) was necessary for triiodothyronine to modulate HIF1A and TGFA (show TGFA Antibodies) expression

  10. The finding that overexpression of HIF-1alpha increased the activity of the CYP7A1 (show CYP7A1 Antibodies) promoter suggested that hypoxia decreased the expression of CYP7A1 (show CYP7A1 Antibodies) in a HIF-1-independent manner.

Pig (Porcine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Upregulation of VEGF (show VEGFA Antibodies) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

  2. HIF-1alpha activates Sox9 (show SOX9 Antibodies) expression and enhances Sox9 (show SOX9 Antibodies)-mediated transcriptional activity.

  3. Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.

  4. immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 Antibodies) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 Antibodies) was present at sites of intramembranous ossification

  5. Downregulation of miR (show MYLIP Antibodies)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 Antibodies) and recapitulates hypoxia preconditioning in cardiac myocytes.

  6. Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.

Cow (Bovine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.

  2. hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity

  3. VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself

  4. Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.

Rabbit Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  2. HIF-1alpha-induced HSP70 (show HSP70 Antibodies) overexpression increased the expression levels of ECM (show MMRN1 Antibodies) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 Antibodies) expression

  3. Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.

  4. Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.

  5. HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.

  6. Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1

  7. Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.

  8. rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.

  9. Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion

Caenorhabditis elegans (C. elegans) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. HIF-1-mediated activation of 5-HT (show DDC Antibodies) signalling promotes axon regeneration by activating both the RhoA (show RHOA Antibodies) and cAMP pathways.

  2. this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 Antibodies)).

  3. AMPK (show PRKAA1 Antibodies) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 Antibodies)

  4. Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.

  5. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 Antibodies) compromised C. elegans dauer larvae.

  6. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.

  7. Data indicate that genes sqrd-1, ethe-1 (show ETHE1 Antibodies), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (show SQRDL Antibodies) and hydrogen cyanide.

  8. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.

  9. Data show that that reactive oxygen species (ROS (show ROS1 Antibodies)) are increased in respiration mutants and that mild increases in ROS (show ROS1 Antibodies) can stimulate HIF-1 to activate gene expression and promote longevity.

  10. These data support a model in which SWAN-1 (show DCAF7 Antibodies), MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 (show SMOX Antibodies) fast killing.

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Antigen Profile

Protein Summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with HIF1A

  • hypoxia inducible factor 1 alpha (hif-1a) antibody
  • hypoxia inducible factor 1, alpha subunit (Hif1a) antibody
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A) antibody
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a) antibody
  • hypoxia-inducible factor 1 alpha (hif-1a) antibody
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a) antibody
  • Protein HIF-1 (hif-1) antibody
  • AA959795 antibody
  • bHLHe78 antibody
  • hif-1a antibody
  • HIF-1alpha antibody
  • HIF1 antibody
  • HIF1-alpha antibody
  • hif1a antibody
  • HIF1alpha antibody
  • MOP1 antibody
  • PASD8 antibody

Protein level used designations for HIF1A

HIF-1 alpha , HIF-1-alpha , HIF1 alpha , HIF1-alpha , Hypoxia-inducible factor 1 alpha , hypoxia-inducible factor 1-alpha , ARNT-interacting protein , ARNT interacting protein , PAS domain-containing protein 8 , basic-helix-loop-helix-PAS protein MOP1 , class E basic helix-loop-helix protein 78 , hypoxia-inducible factor 1 alpha isoform I.3 , hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) , hypoxia-inducible factor1alpha , member of PAS protein 1 , member of PAS superfamily 1 , hypoxia-inducible factor 1 alpha , hypoxia inducible factor 1 alpha subunit , hypoxia inducible factor 1, alpha subunit

GENE ID SPECIES
100337573 Xenopus laevis
15251 Mus musculus
3091 Homo sapiens
396696 Sus scrofa
281814 Bos taurus
101692645 Mustela putorius furo
443519 Ovis aries
100009579 Oryctolagus cuniculus
480348 Canis lupus familiaris
100713113 Cavia porcellus
374177 Gallus gallus
100135944 Oncorhynchus mykiss
29560 Rattus norvegicus
180359 Caenorhabditis elegans
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