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HIF1A encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. Additionally we are shipping Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Kits (83) and Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (50) and many more products for this protein.
Showing 10 out of 652 products:
Cow (Bovine) Monoclonal HIF1A Primary Antibody for ChIP, ELISA - ABIN151032
Bernhardt, Câmpean, Kany, Jürgensen, Weidemann, Warnecke, Arend, Klaus, Günzler, Amann, Willam, Wiesener, Eckardt: Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. in Journal of the American Society of Nephrology : JASN 2006
Show all 608 references for ABIN151032
Cow (Bovine) Monoclonal HIF1A Primary Antibody for ICC, IF - ABIN151061
Abbate, Santini, Biondi-Zoccai, Scarpa, Vasaturo, Liuzzo, Bussani, Silvestri, Baldi, Crea, Biasucci, Baldi: Cyclo-oxygenase-2 (COX-2) expression at the site of recent myocardial infarction: friend or foe? in Heart (British Cardiac Society) 2004
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Cow (Bovine) Monoclonal HIF1A Primary Antibody for ICC, IF - ABIN863097
Surazynski, Miltyk, Prokop, Palka: The effect of estrogen on prolidase-dependent regulation of HIF-1α expression in breast cancer cells. in Molecular and cellular biochemistry 2013
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Human Monoclonal HIF1A Primary Antibody for IHC (p), IP - ABIN151762
Gillespie, Whang, Ragel, Flynn, Kelly, Jensen: Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. in Clinical cancer research : an official journal of the American Association for Cancer Research 2007
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Human Polyclonal HIF1A Primary Antibody for IF, IHC (p) - ABIN392176
Favaro, Nardo, Persano, Masiero, Moserle, Zamarchi, Rossi, Esposito, Plebani, Sattler, Mann, Mueller-Klieser, Ciminale, Amadori, Indraccolo: Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death. in The American journal of pathology 2008
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Human Monoclonal HIF1A Primary Antibody for EMSA, IF - ABIN114960
Arany, Huang, Eckner, Bhattacharya, Jiang, Goldberg, Bunn, Livingston: An essential role for p300/CBP in the cellular response to hypoxia. in Proceedings of the National Academy of Sciences of the United States of America 1996
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Human Polyclonal HIF1A Primary Antibody for FACS, IF - ABIN652389
Lee, Lee, Kim, Kim, Jung, Seo, Park, Choi, Yim, Lee, Park, Yoo, Kim, Lee, Kim, Ryeom, Kim, Oh: Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis. in Journal of the National Cancer Institute 2010
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Human Polyclonal HIF1A Primary Antibody for EIA, IHC (p) - ABIN360059
Alexandru, Graumann, Smith, Kolawa, Fang, Deshaies: UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. in Cell 2008
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Chicken Polyclonal HIF1A Primary Antibody for WB - ABIN2780373
Kitajima, Ide, Ohtsuka, Miyazaki: Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. in Cancer science 2008
In this review, mouse models of sleep apnea show that disruption of HIF-1alpha (and HIF-2alpha (show EPAS1 Antibodies)) balance results in hypertension.
Hif-1alpha is a key regulator in the metabolic adaptation to high-intensity training
SART1 (show SART1 Antibodies)(+/-) mice showed significant up-regulation of HIF-1alpha in circulating and liver-infiltrating immune cells
OGA (show MGEA5 Antibodies) plays a critical role in placental vasculogenesis by modulating HIF-1alpha stabilization.
the involvement of PAI-1 (show SERPINE1 Antibodies) in HIF-1-enhanced thrombosis and that an additional factor participates in regulating Pai-1 (show SERPINE1 Antibodies) expression in compressed skin.
In conclusion, saturated free fatty acid induced proinflammatory cytokine production partly through activation of a novel lactate-HIF1alpha pathway in chondrocytes.
suggest that tumor and endothelial cell-specific HIF1alpha may have opposing roles in cancer-associated coagulation and thrombosis.
HIF1alpha has a role in inflammation in a mouse model of proximal colon cancer
exposure of primary hepatocytes to hypoxia or transgenic overexpression of HIF-1alpha in the mouse liver was sufficient to induce the expression of FABP4 (show FABP4 Antibodies).
Dll4 (show DLL4 Antibodies)/Notch (show NOTCH1 Antibodies) signaling and HIF-1alpha are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.
The present study demonstrated that the antiapoptotic effect of TMP in CoCl2-induced HUVECs was, at least in part, via the regulation of the PHD2 (show EGLN1 Antibodies)/HIF-1alpha signaling pathway.
Serum concentrations of HIF-1alpha (t=25.53, P<0.05) and VEGF (t=12.10, P<0.05) in early stage group were significantly higher than those in normal group.
We concluded that local recurrences of SCLCs caused by overproliferation of micrometastases following RFA (show RPA1 Antibodies) treatment were driven by HIF-1alpha, although angiogenesis was not the driving force in the TZ.
IHC staining of human BCa (show BLNK Antibodies) tissue supported our conclusion that the expression of HIF-1a and MDR1 (show TBC1D9 Antibodies) was higher in chemoresistant tissue vs. chemosensitive tissue.
miR (show MLXIP Antibodies)-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model, which was probably caused by the downregulation of pro-angiogenic molecules, such as VEGF (show VEGFA Antibodies) and HIF-1alpha.
Our data suggest that CXCL16 (show CXCL16 Antibodies) induces angiogenesis in autocrine manner via ERK (show EPHB2 Antibodies), Akt (show AKT1 Antibodies), p38 (show CRK Antibodies) pathways and HIF-1alpha modulation
Resveratrol inhibited hypoxia-induced HIF-1alpha protein expression. Resveratrol also suppressed hypoxiainduced expression of metastatic-related factors, uPA (show PRAP1 Antibodies) and MMP2 (show MMP2 Antibodies).
The results suggest a possible role for the oxygen-dependent protein folding process from the ER-Golgi compartment in fine-tuning HIF1a transcriptional output.
REST represses transcription of HIF-1alpha in prolonged hypoxia, thus contributing to the resolution of the HIF-1alpha response.
Hypoxia enhanced the endogenous HIF-1alpha protein expression.HIF-1 protein bound the putative HIF-1 response element on the uPAR (show PLAUR Antibodies) promoter.
Upregulation of VEGF (show VEGFA Antibodies) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.
HIF-1alpha activates Sox9 (show SOX9 Antibodies) expression and enhances Sox9 (show SOX9 Antibodies)-mediated transcriptional activity.
Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.
immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 Antibodies) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 Antibodies) was present at sites of intramembranous ossification
Downregulation of miR (show MYLIP Antibodies)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 Antibodies) and recapitulates hypoxia preconditioning in cardiac myocytes.
Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.
Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.
hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity
VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself
Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.
Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.
HIF-1alpha-induced HSP70 (show HSP70 Antibodies) overexpression increased the expression levels of ECM (show MMRN1 Antibodies) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 Antibodies) expression
Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.
Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.
HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.
Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1
Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.
rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.
Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion
HIF-1-mediated activation of 5-HT (show DDC Antibodies) signalling promotes axon regeneration by activating both the RhoA (show RHOA Antibodies) and cAMP pathways.
this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 Antibodies)).
AMPK (show PRKAA1 Antibodies) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 Antibodies)
Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.
Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 Antibodies) compromised C. elegans dauer larvae.
These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.
Data indicate that genes sqrd-1, ethe-1 (show ETHE1 Antibodies), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (show SQRDL Antibodies) and hydrogen cyanide.
Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.
Data show that that reactive oxygen species (ROS (show ROS1 Antibodies)) are increased in respiration mutants and that mild increases in ROS (show ROS1 Antibodies) can stimulate HIF-1 to activate gene expression and promote longevity.
These data support a model in which SWAN-1 (show DCAF7 Antibodies), MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 (show SMOX Antibodies) fast killing.
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
, HIF1 alpha
, Hypoxia-inducible factor 1 alpha
, hypoxia-inducible factor 1-alpha
, ARNT-interacting protein
, ARNT interacting protein
, PAS domain-containing protein 8
, basic-helix-loop-helix-PAS protein MOP1
, class E basic helix-loop-helix protein 78
, hypoxia-inducible factor 1 alpha isoform I.3
, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
, hypoxia-inducible factor1alpha
, member of PAS protein 1
, member of PAS superfamily 1
, hypoxia-inducible factor 1 alpha
, hypoxia inducible factor 1 alpha subunit
, hypoxia inducible factor 1, alpha subunit