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anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Antibodies

HIF1A encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. Additionally we are shipping Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Kits (83) and Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Proteins (50) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HIF1A 15251 Q61221
HIF1A 3091 Q16665
Anti-Rat HIF1A HIF1A 29560 O35800
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Top anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Antibodies at antibodies-online.com

Showing 10 out of 624 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB Sample Type: Chicken Liver Nuclei (50ug)Primary Dilution: 1:1000Secondary Antibody: goat anti-rabbit HRPSecondary Dilution: 1:2000Image Submitted By: Silvia MooreWeill Cornell Medical College 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated FACS, IF, IHC (p), WB Western blot analysis of HIF1Alpha Antibody (Center) (ABIN652389) in mouse NIH-3T3 cell line lysates (35 µg/lane). HIF1Alpha (arrow) was detected using the purified polyclonal antibody. HIF1Alpha Antibody (Center)(ABIN652389) IHC analysis in formalin fixed and paraffin embedded lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Hamster Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of HIF1A Antibody (N-term) (ABIN650972) in CHO cell line lysates (35 µg/lane). HIF1A (arrow) was detected using the purified polyclonal antibody. HIF1A Antibody (N-term)(ABIN650972) IHC analysis in formalin fixed and paraffin embedded lung carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Western blot analysis of HIF1Alpha Antibody (C-term) (ABIN392176) in MDA-MB231 cell line lysates (35 µg/lane). HIF1Alpha (arrow) was detected using the purified polyclonal antibody. Western blot analysis of HIF1Alpha Antibody (C-term) (ABIN392176) in mouse cerebellum tissue lysates (35 µg/lane). HIF1Alpha (arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Mouse Un-conjugated ICC, IF, IHC, ELISA, WB HIF1alpha (EP190b), Mosue backskin. Hif1alpha WB 1 in 500 in Hela 20ug untreated 100 μg Log in to see 3 to 4 Days
$349.80
Details
Human Mouse Un-conjugated EMSA, IF, IP, WB Western blot analysis of human lung cell 0.5 mL Log in to see 6 to 8 Days
$423.50
Details
Human Rabbit Un-conjugated WB HIF1A Antibody (C-term) (ABIN1881413) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the HIF1A antibody detected the HIF1A protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated ICC, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunofluorescence analysis of Hela cells using HIF1A mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human cervical carcinoma labeled Anti-HIF-1-Alpha Polyclonal Antibody (ABIN672546), Unconjugated at 1:300, followed by conjugation to the secondary antibody and DAB staining L1 mouse heart lysates, L2 mouse large intestine lysates probed with Anti HIF-1 Alpha Polyclonal Antibody, Unconjugated (ABIN672546) at 1:200 in 4 °C. Followed by conjugation to secondary antibody at 1:3000 90min in 37 °C. Predicted band and observed band size: 92kD 100 μL Log in to see 3 to 7 Days
$269.50
Details

HIF1A Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Antibodies

  1. Cow (Bovine) Monoclonal HIF1A Primary Antibody for ICC, IF - ABIN863097 : Surazynski, Miltyk, Prokop, Palka: The effect of estrogen on prolidase-dependent regulation of HIF-1α expression in breast cancer cells. in Molecular and cellular biochemistry 2013 (PubMed)
    Show all 9 references for ABIN863097

  2. Human Polyclonal HIF1A Primary Antibody for WB - ABIN1881413 : Espinosa, José Carnicer, Catasus, Canet, Dangelo, Zannoni, Prat: Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role. in The American journal of surgical pathology 2010 (PubMed)
    Show all 5 references for ABIN1881413

  3. Human Polyclonal HIF1A Primary Antibody for IF (p), IHC (p) - ABIN672546 : Shou, Lin, Liang, Li, Chen: Expression and prognosis of FOXO3a and HIF-1? in nasopharyngeal carcinoma. in Journal of cancer research and clinical oncology 2012 (PubMed)
    Show all 5 references for ABIN672546

  4. Human Polyclonal HIF1A Primary Antibody for IF, IHC (p) - ABIN392176 : Favaro, Nardo, Persano, Masiero, Moserle, Zamarchi, Rossi, Esposito, Plebani, Sattler, Mann, Mueller-Klieser, Ciminale, Amadori, Indraccolo: Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death. in The American journal of pathology 2008 (PubMed)
    Show all 3 references for ABIN392176

  5. Human Polyclonal HIF1A Primary Antibody for FACS, IF - ABIN652389 : Lee, Lee, Kim, Kim, Jung, Seo, Park, Choi, Yim, Lee, Park, Yoo, Kim, Lee, Kim, Ryeom, Kim, Oh: Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis. in Journal of the National Cancer Institute 2010 (PubMed)
    Show all 2 references for ABIN652389

  6. Human Monoclonal HIF1A Primary Antibody for ICC, IHC - ABIN969193 : Mounier, Pialoux, Roels, Thomas, Millet, Mercier, Coudert, Fellmann, Clottes: Effect of intermittent hypoxic training on HIF gene expression in human skeletal muscle and leukocytes. in European journal of applied physiology 2009 (PubMed)
    Show all 2 references for ABIN969193

  7. Human Monoclonal HIF1A Primary Antibody for EMSA, IF - ABIN114960 : Arany, Huang, Eckner, Bhattacharya, Jiang, Goldberg, Bunn, Livingston: An essential role for p300/CBP in the cellular response to hypoxia. in Proceedings of the National Academy of Sciences of the United States of America 1996 (PubMed)
    Show all 2 references for ABIN114960

  8. Human Polyclonal HIF1A Primary Antibody for EIA, IHC (p) - ABIN360059 : Alexandru, Graumann, Smith, Kolawa, Fang, Deshaies: UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover. in Cell 2008 (PubMed)
    Show all 2 references for ABIN360059

  9. Chicken Polyclonal HIF1A Primary Antibody for WB - ABIN2780373 : Kitajima, Ide, Ohtsuka, Miyazaki: Induction of hepatocyte growth factor activator gene expression under hypoxia activates the hepatocyte growth factor/c-Met system via hypoxia inducible factor-1 in pancreatic cancer. in Cancer science 2008 (PubMed)

More Antibodies against Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Interaction Partners

Mouse (Murine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. In this review, mouse models of sleep apnea show that disruption of HIF-1alpha (and HIF-2alpha (show EPAS1 Antibodies)) balance results in hypertension.

  2. Hif-1alpha is a key regulator in the metabolic adaptation to high-intensity training

  3. SART1 (show SART1 Antibodies)(+/-) mice showed significant up-regulation of HIF-1alpha in circulating and liver-infiltrating immune cells

  4. OGA (show MGEA5 Antibodies) plays a critical role in placental vasculogenesis by modulating HIF-1alpha stabilization.

  5. the involvement of PAI-1 (show SERPINE1 Antibodies) in HIF-1-enhanced thrombosis and that an additional factor participates in regulating Pai-1 (show SERPINE1 Antibodies) expression in compressed skin.

  6. In conclusion, saturated free fatty acid induced proinflammatory cytokine production partly through activation of a novel lactate-HIF1alpha pathway in chondrocytes.

  7. suggest that tumor and endothelial cell-specific HIF1alpha may have opposing roles in cancer-associated coagulation and thrombosis.

  8. HIF1alpha has a role in inflammation in a mouse model of proximal colon cancer

  9. exposure of primary hepatocytes to hypoxia or transgenic overexpression of HIF-1alpha in the mouse liver was sufficient to induce the expression of FABP4 (show FABP4 Antibodies).

  10. Dll4 (show DLL4 Antibodies)/Notch (show NOTCH1 Antibodies) signaling and HIF-1alpha are closely related to lymphangiogenesis in dry eye-induced lacrimal glands.

Human Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. The present study demonstrated that the antiapoptotic effect of TMP in CoCl2-induced HUVECs was, at least in part, via the regulation of the PHD2 (show EGLN1 Antibodies)/HIF-1alpha signaling pathway.

  2. Serum concentrations of HIF-1alpha (t=25.53, P<0.05) and VEGF (t=12.10, P<0.05) in early stage group were significantly higher than those in normal group.

  3. We concluded that local recurrences of SCLCs caused by overproliferation of micrometastases following RFA (show RPA1 Antibodies) treatment were driven by HIF-1alpha, although angiogenesis was not the driving force in the TZ.

  4. IHC staining of human BCa (show BLNK Antibodies) tissue supported our conclusion that the expression of HIF-1a and MDR1 (show TBC1D9 Antibodies) was higher in chemoresistant tissue vs. chemosensitive tissue.

  5. miR (show MLXIP Antibodies)-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model, which was probably caused by the downregulation of pro-angiogenic molecules, such as VEGF (show VEGFA Antibodies) and HIF-1alpha.

  6. Our data suggest that CXCL16 (show CXCL16 Antibodies) induces angiogenesis in autocrine manner via ERK (show EPHB2 Antibodies), Akt (show AKT1 Antibodies), p38 (show CRK Antibodies) pathways and HIF-1alpha modulation

  7. Resveratrol inhibited hypoxia-induced HIF-1alpha protein expression. Resveratrol also suppressed hypoxiainduced expression of metastatic-related factors, uPA (show PRAP1 Antibodies) and MMP2 (show MMP2 Antibodies).

  8. The results suggest a possible role for the oxygen-dependent protein folding process from the ER-Golgi compartment in fine-tuning HIF1a transcriptional output.

  9. REST represses transcription of HIF-1alpha in prolonged hypoxia, thus contributing to the resolution of the HIF-1alpha response.

  10. Hypoxia enhanced the endogenous HIF-1alpha protein expression.HIF-1 protein bound the putative HIF-1 response element on the uPAR (show PLAUR Antibodies) promoter.

Pig (Porcine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Upregulation of VEGF (show VEGFA Antibodies) during hypoxia in chondrocyte is mediated partially through HIF-1alpha.

  2. HIF-1alpha activates Sox9 (show SOX9 Antibodies) expression and enhances Sox9 (show SOX9 Antibodies)-mediated transcriptional activity.

  3. Intramyocardial delivery of mesenchymal stem cells seems to trigger the release of angiogenic HIF-1alpha more effectively than does intracoronary delivery.

  4. immunostaining for HIF-1alpha and HIF-2alpha (show EPAS1 Antibodies) was observed during endochondral ossification, whereas only HIF-2alpha (show EPAS1 Antibodies) was present at sites of intramembranous ossification

  5. Downregulation of miR (show MYLIP Antibodies)-199a derepresses hypoxia-inducible factor-1alpha and Sirtuin 1 (show SIRT1 Antibodies) and recapitulates hypoxia preconditioning in cardiac myocytes.

  6. Viable chondrocytes in the superficial layer of the epiphyseal cartilage showed HIF-1alpha activation and VEGF upregulation with subsequent revascularization occurring in the cartilage.

Cow (Bovine) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Hypoxia increased the amounts of HIF1A protein, VEGF mRNA and VEGF protein in cultured bovine luteal cells.

  2. hypoxia-induced changes in vascular cell growth are altered by hyperglycemia via inhibition of HIF-1alpha expression and activity

  3. VEGF has an effect on the expression of its own transcription factor, HIF-1, and on VEGF itself

  4. Identify sphingosine-1-phosphate as a novel and potent nonhypoxic activator of HIF-1.

Rabbit Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. Suggest supplemental oxygen inhibits HIF-1alpha/VEGF signaling to reduce smooth muscle proliferation in rabbit arteriovenous fistula model.

  2. HIF-1alpha-induced HSP70 (show HSP70 Antibodies) overexpression increased the expression levels of ECM (show MMRN1 Antibodies) genes and cell viability, and protected chondrocytes from apoptosis. HIF-1alpha may regulate anabolic effects of chondrocytes under hypoxic conditions by regulating HSP70 (show HSP70 Antibodies) expression

  3. Transcatheter arterial embolization of liver tumors increases the expression of HIF-1alpha at protein level in the residual viable tumor.

  4. Upregulation of HIF-1 protects cardiac myocyte function after ischemia/reperfusion by maintaining calcium release.

  5. HIF-1alpha expression in early atherosclerosis can promote the formation of neovascularization.

  6. Xells respond to hypoxia through a transcription factor, hypoxia-inducible factor 1

  7. Upregulation of HIF-1 could protect isolated cardiac myocytes against nitrate tolerance through a cyclic GMP protein kinase-independent mechanism and through a kinase-dependent mechanism in myocardial stunning.

  8. rhEPO can down-regulate HIF-1alpha expression in the retina of rabbits with acute high intraocular pressure.

  9. Increased HIF-1 alpha protects the functional effects of cyclic GMP thorough maintenance of cyclic GMP protein kinase activity after ischemic-reperfusion

Caenorhabditis elegans (C. elegans) Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) interaction partners

  1. HIF-1-mediated activation of 5-HT (show DDC Antibodies) signalling promotes axon regeneration by activating both the RhoA (show RHOA Antibodies) and cAMP pathways.

  2. this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2 (show FMO2 Antibodies)).

  3. AMPK (show PRKAA1 Antibodies) and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS (show ROS1 Antibodies)

  4. Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1.

  5. Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK (show PRKAA1 Antibodies) compromised C. elegans dauer larvae.

  6. These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage.

  7. Data indicate that genes sqrd-1, ethe-1 (show ETHE1 Antibodies), cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide (show SQRDL Antibodies) and hydrogen cyanide.

  8. Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner.

  9. Data show that that reactive oxygen species (ROS (show ROS1 Antibodies)) are increased in respiration mutants and that mild increases in ROS (show ROS1 Antibodies) can stimulate HIF-1 to activate gene expression and promote longevity.

  10. These data support a model in which SWAN-1 (show DCAF7 Antibodies), MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 (show SMOX Antibodies) fast killing.

Hypoxia Inducible Factor 1, alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) (HIF1A) Antigen Profile

Protein Summary

This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

Gene names and symbols associated with HIF1A

  • hypoxia inducible factor 1 alpha (hif-1a) antibody
  • hypoxia inducible factor 1, alpha subunit (Hif1a) antibody
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (HIF1A) antibody
  • hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a) antibody
  • hypoxia-inducible factor 1 alpha (hif-1a) antibody
  • hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) (Hif1a) antibody
  • Protein HIF-1 (hif-1) antibody
  • AA959795 antibody
  • bHLHe78 antibody
  • hif-1a antibody
  • HIF-1alpha antibody
  • HIF1 antibody
  • HIF1-alpha antibody
  • hif1a antibody
  • HIF1alpha antibody
  • MOP1 antibody
  • PASD8 antibody

Protein level used designations for HIF1A

HIF-1 alpha , HIF-1-alpha , HIF1 alpha , HIF1-alpha , Hypoxia-inducible factor 1 alpha , hypoxia-inducible factor 1-alpha , ARNT-interacting protein , ARNT interacting protein , PAS domain-containing protein 8 , basic-helix-loop-helix-PAS protein MOP1 , class E basic helix-loop-helix protein 78 , hypoxia-inducible factor 1 alpha isoform I.3 , hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) , hypoxia-inducible factor1alpha , member of PAS protein 1 , member of PAS superfamily 1 , hypoxia-inducible factor 1 alpha , hypoxia inducible factor 1 alpha subunit , hypoxia inducible factor 1, alpha subunit

GENE ID SPECIES
100337573 Xenopus laevis
15251 Mus musculus
3091 Homo sapiens
396696 Sus scrofa
281814 Bos taurus
101692645 Mustela putorius furo
443519 Ovis aries
100009579 Oryctolagus cuniculus
480348 Canis lupus familiaris
100713113 Cavia porcellus
374177 Gallus gallus
100135944 Oncorhynchus mykiss
29560 Rattus norvegicus
180359 Caenorhabditis elegans
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