Hypoxia Inducible Factor 3, alpha Subunit Proteins (HIF3A)

The protein encoded by HIF3A is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). Additionally we are shipping HIF3A Antibodies (97) and HIF3A Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
HIF3A 53417 Q0VBL6
HIF3A 64345 Q9JHS2
HIF3A 64344 Q9Y2N7
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Top HIF3A Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,921.50
Details

HIF3A Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Rat (Rattus)

Human ,
,

More Proteins for Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) Interaction Partners

Cow (Bovine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

Zebrafish Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

Mouse (Murine) Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. Report suggests that BV-2 microglial cells express HIF-3a under inflammatory conditions and that its activation differed from that of HIF-1a (show HIF1A Proteins)

  2. mRNA of HIF-2alpha (show EPAS1 Proteins) and Ets-1 (show ETS1 Proteins) were significantly increased by HIF-3alpha ablation. Both factors activate the VE-cadherin (show CDH5 Proteins) gene, the transcriptional repression of these factors by HIF-3alpha is important for silencing the irrelevant expression of the VE-cadherin (show CDH5 Proteins) gene.

  3. our data indicated that Tnni2K175del mutation led to abnormally increased hif3a and decreased vegf in bone, which explain, at least in part, the small body size of Tnni2K175del mice

  4. Anoxia preconditioning increases anti-ischemic neuronal resistance which to a certain extent correlates with the changes of HIF-1alpha (show HIF1A Proteins) and HIF-3alpha expression.

  5. alternative splicing and expression of IPAS is induced by hypoxia.

  6. By generating mice with a targeted disruption of the NEPAS/HIF-3alpha locus, it was found that homozygous mutant mice, NEPAS/HIF-3alpha(-/-), were viable but displayed enlargement of the right ventricle and impaired lung remodeling.

  7. Identity of third HIF alpha class member, HIF-3alpha. mRNA expression information by mouse MTN. Experimental proof of dimerization with ARNT/HIF-1beta (show ARNT Proteins).

Human Hypoxia Inducible Factor 3, alpha Subunit (HIF3A) interaction partners

  1. HIF3A methylation was found in the association between the HIF3A rs3826795 polymorphism and alanine aminotransferase (show ALT Proteins) among obese children.

  2. TIMP2 (show TIMP2 Proteins) suppression, in a hypoxic environment, was induced through a regulatory feedback circuit consisting of hypoxia-inducible factor (HIF) 1 alpha (show HIF1A Proteins), microRNA-210 (miR (show MLXIP Proteins)-210), and HIF-3alpha.

  3. Results were discordant with those expected if HIF3A methylation has a causal effect on body mass index (BMI) & provided more evidence for causality in the reverse direction (i.e., an effect of BMI on HIF3A methylation); results also show a long-lasting intergenerational influence of maternal BMI on offspring methylation at this locus, which may confound associations between own adiposity & HIF3A methylation.

  4. DNA methylation (show HELLS Proteins) in HIF3A shares moderate correlation between adipose tissue and blood, and both are associated with BMI. In contrast, methylation in FASN (show FASN Proteins) is poorly correlated across tissues, but the DNA methylation (show HELLS Proteins) in adipose tissue but not blood is highly associated with BMI

  5. Reduced lifetimes of the donor were partially restored by coexpression of HIF-1alpha (show HIF1A Proteins) or Bcl-xL (show BCL2L1 Proteins), binding proteins of IPAS in the nucleus and mitochondria, respectively.

  6. Results confirmed a positive association between BMI and HIF3A DNA promoter methylation in the blood. The tissue-specific results of HIF3A gene expression indicate that subcutaneous adipose tissue is the more functional tissue in which a low expression may adversely affect whole-body insulin (show INS Proteins) sensitivity.

  7. Parkin (show PARK2 Proteins) is downregulated under hypoxia and that it interferes with HIF expression based on cellular oxygen tension.

  8. This provides a compelling model for how hypoxia-induced miR (show MLXIP Proteins)-429 regulates the switch between HIF-1 (show HIF1A Proteins) adaptive responses to HIF-3 survival responses by rapidly decreasing HIF1A (show HIF1A Proteins) levels while simultaneously slowing the progression of HIF3A expression until the miR (show MLXIP Proteins)-429 levels drop below normoxic levels.

  9. The association between increased DNA methylation (show HELLS Proteins) at HIF3A and increased adiposity is present in neonates.

  10. HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT

HIF3A Protein Profile

Protein Summary

The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. Multiple alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with HIF3A

  • hypoxia inducible factor 3, alpha subunit (HIF3A)
  • hypoxia-inducible factor 1, alpha subunit, like (hif1al)
  • hypoxia inducible factor 3, alpha subunit (Hif3a)
  • bHLHe17 protein
  • HIF-3A protein
  • HIF3A protein
  • IPAS protein
  • Mop7 protein
  • NEPAS protein
  • PASD7 protein
  • zgc:63965 protein

Protein level used designations for HIF3A

hypoxia inducible factor 3, alpha subunit , Hif3a , Hif3a-like , hypoxia-inducible factor 3 alpha subunit , hypoxia-inducible factor 3-alpha , hypoxia-inducible factor-3 alpha , hypoxia-inducible factor 3-alpha-like , HIF-3-alpha , HIF3-alpha , HIF3-alpha-1 , basic-helix-loop-helix-PAS protein MOP7 , hypoxia inducible factor three alpha , inhibitory PAS domain protein , member of PAS protein 7 , neonatal and embryonic PAS , HIF-3 alpha , HIF3 alpha 1 , hypoxia inducible factor 3 alpha , hypoxia inducible factor 3a , hypoxia-inducible factor 3 alpha , PAS domain-containing protein 7 , class E basic helix-loop-helix protein 17

GENE ID SPECIES
281815 Bos taurus
393376 Danio rerio
456149 Pan troglodytes
100135687 Ovis aries
100413902 Callithrix jacchus
100442498 Pongo abelii
100473029 Ailuropoda melanoleuca
100582446 Nomascus leucogenys
53417 Mus musculus
64345 Rattus norvegicus
64344 Homo sapiens
476429 Canis lupus familiaris
100621574 Sus scrofa
507699 Bos taurus
100071095 Equus caballus
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