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IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping IKZF3 Proteins (5) and IKZF3 Kits (1) and many more products for this protein.
Showing 10 out of 113 products:
Human Monoclonal IKZF3 Primary Antibody for IF - ABIN394045
Matulić, Paradzik, Puskarić, Stipić, Antica: Analysis of Ikaros family splicing variants in human hematopoietic lineages. in Collegium antropologicum 2010
Show all 5 references for ABIN394045
Mouse (Murine) Monoclonal IKZF3 Primary Antibody for FACS - ABIN2657113
Cariappa, Tang, Parng, Nebelitskiy, Carroll, Georgopoulos, Pillai: The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. in Immunity 2001
Show all 4 references for ABIN2657113
Mouse (Murine) Monoclonal IKZF3 Primary Antibody for FACS - ABIN2662381
Wang, Avitahl, Cariappa, Friedrich, Ikeda, Renold, Andrikopoulos, Liang, Pillai, Morgan, Georgopoulos: Aiolos regulates B cell activation and maturation to effector state. in Immunity 1998
Show all 4 references for ABIN2662381
Human Monoclonal IKZF3 Primary Antibody for IF, ELISA - ABIN564938
Matulic, Paradzik, Cicin-Sain, Kapitanovic, Dubravcic, Batinic, Antica: Ikaros family transcription factors in chronic and acute leukemia. in American journal of hematology 2009
Mouse (Murine) Monoclonal IKZF3 Primary Antibody for ChIP, WB - ABIN2668825
Thompson, Cobb, Sabbattini, Meixlsperger, Parelho, Liberg, Taylor, Dillon, Georgopoulos, Jumaa, Smale, Fisher, Merkenschlager: Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. in Immunity 2007
Human Polyclonal IKZF3 Primary Antibody for ELISA, WB - ABIN1534187
Hosokawa, Maeda, Takahashi, Suzuki, Seto: Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping. in Genomics 2000
Human Polyclonal IKZF3 Primary Antibody for WB - ABIN651843
Mavaddat, Dunning, Ponder, Easton, Pharoah: Common genetic variation in candidate genes and susceptibility to subtypes of breast cancer. in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2009
Cow (Bovine) Polyclonal IKZF3 Primary Antibody for IHC, WB - ABIN2780886
Koipally, Georgopoulos: A molecular dissection of the repression circuitry of Ikaros. in The Journal of biological chemistry 2002
Chicken Polyclonal IKZF3 Primary Antibody for WB - ABIN2780887
Antica, Cicin-Sain, Sain, Kapitanovic, Matulic, Dzebro, Dominis: Aberrant Ikaros, Aiolos, and Helios expression in Hodgkin and non-Hodgkin lymphoma. in Blood 2008
These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.
study demonstrated that Aiolos silenced the Il2 (show IL2 Antibodies) locus, promoting TH17 differentiation in vitro and in vivo
Aiolos and Ikaros (show IKZF1 Antibodies) bind to the c-myc (show MYC Antibodies) promoter in vivo and directly suppress c-myc (show MYC Antibodies) expression in pre-B cells.
Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.
A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (show IL4 Antibodies)-deprived cells via association to the transcription factor Aiolos.
Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.
A novel role for OBF-1 (show POU2AF1 Antibodies) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (show BCR Antibodies) function.
Aiolos improved the survival of Nalm6 cells via PTEN (show PTEN Antibodies) and Aktdependent processes.
NFKB1 (show NFKB1 Antibodies), CD27 (show CD27 Antibodies), LAG3 (show LAG3 Antibodies) and IKZF3 are new susceptibility genes for psoriasis.
lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (show NFKB1 Antibodies) activity.
The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (show ZPBP2 Antibodies) locus confers risk for early-onset psoriasis.
A strong association between rs907091 in the IKZF3 gene and SLE was identified.
The immunosuppressive enzyme IL4I1 (show IL4I1 Antibodies) expressed differentially in human induced Aiolos+, but not natural Helios (show ZNFN1A2 Antibodies)+, FOXP3 (show FOXP3 Antibodies)+ Treg cells.
A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population.
Overexpression of AIOLOS inhibits cell proliferation, suppresses apoptosis and arrests the cell cycle at the G0/G1 phase in vitro.
Aiolos reconfigures chromatin structure within the SHC1 (show SHC1 Antibodies) gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo.
Sixteen SNPs were significantly associated with asthma of which one SNP was novel (IKZF3-rs1453559).
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
ikaros family zinc finger protein 3
, zinc finger protein Aiolos
, zinc finger protein, subfamily 1A, 3 (Aiolos)
, lymphoid transcription factor