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IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Additionally we are shipping IKZF3 Antibodies (113) and IKZF3 Kits (1) and many more products for this protein.
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These data place Aiolos in the emerging gene regulatory network controlling NK-cell maturation and function.
study demonstrated that Aiolos silenced the Il2 (show IL2 Proteins) locus, promoting TH17 differentiation in vitro and in vivo
Aiolos and Ikaros (show IKZF1 Proteins) bind to the c-myc (show MYC Proteins) promoter in vivo and directly suppress c-myc (show MYC Proteins) expression in pre-B cells.
Normal Aiolos function is necessary to maintain immune homeostasis and suppress the development of systemic autoimmune disease; Aiolos is implicated as a possible candidate gene for systemic lupus erythematosus.
A model is proposed for the control of Bcl-xL's anti-apoptotic role in IL-4 (show IL4 Proteins)-deprived cells via association to the transcription factor Aiolos.
Failure to generate high affinity plasma cells in the bone marrow and to sustain serum antibody titers is apparent after both primary and secondary immunization of Aiolos(-)(/)(-) mice with a range of hapten concentrations.
A novel role for OBF-1 (show POU2AF1 Proteins) and Aiolos in controlling the transcription and nuclear organization of genes involved in pre-BCR (show BCR Proteins) function.
Aiolos improved the survival of Nalm6 cells via PTEN and Aktdependent processes.
NFKB1 (show NFKB1 Proteins), CD27 (show CD27 Proteins), LAG3 (show LAG3 Proteins) and IKZF3 are new susceptibility genes for psoriasis.
lentivirus-mediated AIOLOS overexpression in Jurkat cells induced cell apoptosis, arrested the cell cycle at the G0/G1 phase, and synergistically increased the sensitivity of Jurkat cells to etoposide by inhibiting NF-kappaB (show NFKB1 Proteins) activity.
The allele T of rs10852936 surrounding the IKZF3-ZPBP2 (show ZPBP2 Proteins) locus confers risk for early-onset psoriasis.
A strong association between rs907091 in the IKZF3 gene and SLE was identified.
The immunosuppressive enzyme IL4I1 (show IL4I1 Proteins) expressed differentially in human induced Aiolos+, but not natural Helios (show ZNFN1A2 Proteins)+, FOXP3 (show FOXP3 Proteins)+ Treg cells.
A strong allelic association between SNPs in the 17q21 region (IKZF3) and asthma has been confirmed for the Latinos population.
Overexpression of AIOLOS inhibits cell proliferation, suppresses apoptosis and arrests the cell cycle at the G0/G1 phase in vitro.
Aiolos reconfigures chromatin structure within the SHC1 (show SHC1 Proteins) gene, causing isoform-specific silencing of the anchorage reporter p66(Shc) and blocking anoikis in vitro and in vivo.
Sixteen SNPs were significantly associated with asthma of which one SNP was novel (IKZF3-rs1453559).
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
ikaros family zinc finger protein 3
, zinc finger protein Aiolos
, zinc finger protein, subfamily 1A, 3 (Aiolos)
, lymphoid transcription factor